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Current Grant Support for Don J. Diamond, PhD

02/10 - 01/16
5R01 AI063356-09 (Barry & Diamond)
NIAID Evaluation of Protective CMV Vaccines in Rhesus Macaques The major goal of this project is to construct and evaluate MVA-based vaccines that target the endocytic pathway of infection using a validated RhCMV challenge model that exhibits shedding and systemic infection.
Role: PD/Principal Investigator
 
06/15 - 05/19
Fortress (Coronado) Biosciences SRA 
Accelerating clinical development of CMVPepVax, CMV-MVA Triplex and CMVConVAX
Role: Principal Investigator
 
 
10/14 – 08/19
1R01HL122216 (Miller)
NIH
Inducing NK cells to remember and fight cancer
Provide regular consults and provide insight into the natural history of CMV infection in transplant recipients and the role of adaptive and innate immunity to control the infection. Pending Review.
Role: Co-Investigator
 
10/14 – 07/19
1R01CA181045-01
CMVPepVax to Protect HCT Recipients from Cytomegalovirus Infection
CMVPepVax will be comprehensively evaluated in HLA-A2 hematopoietic cell transplant (HCT) recipients to discover the optimal formula for immunizing both donors and recipients to prevent CMV viremia
Role: Principal Investigator
 
05/12 - 12/17
5R01 CA077544-13
NCI
Control of CMV infection post-HCT using attenuated MVA-based CMV subunit vaccine The major goal of this continuation project is to evaluate a multi-subunit CMV vaccine in human subjects including a safety study in healthy adults and a therapeutic trial in HCT recipients.
Role: Principal Investigator
 
05/13 – 04/17
R01 AI103960-02 (Diamond & Barry)
NIH
HCMV Vaccine produced from BAC-MVA that Blocks Epithelial and Fibroblast Entry The major goals are to construct an MVA expressing Human-UL128 pentamer using BAC-MVA technology, immunization of RhCMV-negative monkeys, and characterize humoral responses that inhibit CMV infection of fibroblasts and epithelial cells, with and without pp65-gB-MVA.
Role: PD/Principal Investigator (Contact)
 
04/12 – 08/15
Nesvig Foundation Optimizing shRNA Approaches for Control of Experimental Murine Lymphoma using Salmonella Delivery Systems The major goal of this project is to develop a gene-targeting silencing approach to attenuate B-cell lymphoma applicable to future clinical adaptation.
Role: Principal Investigator
 
07/13 – 06/16
R21 CA0174306-02
NIH
IDO-silencing Salmonella therapy for the treatment of primary and metastatic PDAC The major goal of the R21 is to evaluate and optimize an IDO-silencing Salmonella-based therapy (shIDO-ST) for the treatment of advanced pancreatic ductal adenocarcinoma (PDAC).
Role: Principal Investigator
 
01/14–09/16
p53MVA Pipeline Project Award
Phase 1 study combining a p53MVA vaccine with ipilimumab and nivolumab
The p53-MVA vaccine will be given concurrently with other immunomodulatory agents, such as checkpoint inhibitor monoclonal antibodies (e.g. Ipilimumab and/or Nivolumab or Pembrolizumab), with the aim of extending disease progression-free survival.
Role: Principal Investigator

Grant Support

Current Grant Support for Don J. Diamond, PhD

02/10 - 01/16
5R01 AI063356-09 (Barry & Diamond)
NIAID Evaluation of Protective CMV Vaccines in Rhesus Macaques The major goal of this project is to construct and evaluate MVA-based vaccines that target the endocytic pathway of infection using a validated RhCMV challenge model that exhibits shedding and systemic infection.
Role: PD/Principal Investigator
 
06/15 - 05/19
Fortress (Coronado) Biosciences SRA 
Accelerating clinical development of CMVPepVax, CMV-MVA Triplex and CMVConVAX
Role: Principal Investigator
 
 
10/14 – 08/19
1R01HL122216 (Miller)
NIH
Inducing NK cells to remember and fight cancer
Provide regular consults and provide insight into the natural history of CMV infection in transplant recipients and the role of adaptive and innate immunity to control the infection. Pending Review.
Role: Co-Investigator
 
10/14 – 07/19
1R01CA181045-01
CMVPepVax to Protect HCT Recipients from Cytomegalovirus Infection
CMVPepVax will be comprehensively evaluated in HLA-A2 hematopoietic cell transplant (HCT) recipients to discover the optimal formula for immunizing both donors and recipients to prevent CMV viremia
Role: Principal Investigator
 
05/12 - 12/17
5R01 CA077544-13
NCI
Control of CMV infection post-HCT using attenuated MVA-based CMV subunit vaccine The major goal of this continuation project is to evaluate a multi-subunit CMV vaccine in human subjects including a safety study in healthy adults and a therapeutic trial in HCT recipients.
Role: Principal Investigator
 
05/13 – 04/17
R01 AI103960-02 (Diamond & Barry)
NIH
HCMV Vaccine produced from BAC-MVA that Blocks Epithelial and Fibroblast Entry The major goals are to construct an MVA expressing Human-UL128 pentamer using BAC-MVA technology, immunization of RhCMV-negative monkeys, and characterize humoral responses that inhibit CMV infection of fibroblasts and epithelial cells, with and without pp65-gB-MVA.
Role: PD/Principal Investigator (Contact)
 
04/12 – 08/15
Nesvig Foundation Optimizing shRNA Approaches for Control of Experimental Murine Lymphoma using Salmonella Delivery Systems The major goal of this project is to develop a gene-targeting silencing approach to attenuate B-cell lymphoma applicable to future clinical adaptation.
Role: Principal Investigator
 
07/13 – 06/16
R21 CA0174306-02
NIH
IDO-silencing Salmonella therapy for the treatment of primary and metastatic PDAC The major goal of the R21 is to evaluate and optimize an IDO-silencing Salmonella-based therapy (shIDO-ST) for the treatment of advanced pancreatic ductal adenocarcinoma (PDAC).
Role: Principal Investigator
 
01/14–09/16
p53MVA Pipeline Project Award
Phase 1 study combining a p53MVA vaccine with ipilimumab and nivolumab
The p53-MVA vaccine will be given concurrently with other immunomodulatory agents, such as checkpoint inhibitor monoclonal antibodies (e.g. Ipilimumab and/or Nivolumab or Pembrolizumab), with the aim of extending disease progression-free survival.
Role: Principal Investigator
Overview
Beckman Research Institute of City of Hope is responsible for fundamentally expanding the world’s understanding of how biology affects diseases such as cancer, HIV/AIDS and diabetes.
 
 
Research Departments/Divisions

City of Hope is a leader in translational research - integrating basic science, clinical research and patient care.
 

Research Shared Services

City of Hope embodies the spirit of scientific collaboration by sharing services and core facilities with colleagues here and around the world.
 

Our Scientists

Our research laboratories are led by the best and brightest minds in scientific research.
 

City of Hope’s Irell & Manella Graduate School of Biological Sciences equips students with the skills and strategies to transform the future of modern medicine.
Develop new therapies, diagnostics and preventions in the fight against cancer and other life-threatening diseases.
 


NEWS & UPDATES
  • It was 2009 when a City of Hope patient in her 40s learned that the cancer she had been fighting for several years had metastasized to her lungs. Her medical team ran genetic tests on the tumor, but none of the drug therapies available at the time targeted the known mutations in the tumor cells. […]
  • Acute myeloid leukemia (AML) is characterized by a rapidly-developing cancer in the myeloid line of blood cells, which is responsible for producing red blood cells, platelets and several types of white blood cells called granulocytes. Because AML grows rapidly, it can quickly crowd out normal blood cells, leadi...
  • Rachel Divine is a yoga therapist and patient leader for the Sheri & Les Biller Patient and Family Resource Center. She’s also a former City of Hope patient. When someone you know has cancer, even the word “cancer” can make you feel nervous, sleepless, depressed or more. But, as a yoga teacher for 15 ...
  •   Diagnosed with type 1 diabetes when she was 9 years old, Gina Marchini accepted the fact that she would need insulin the rest of her life. Every day, she injected herself with the lifesaving hormone. She also carefully controlled her diet and monitored the rise and fall of her blood glucose with military...
  • The defeat of cancer will require a team effort. Nowhere is this more necessary (or apparent) than in efforts to combat two of the most deadly forms of the disease  – pancreatic cancer and triple-negative breast cancer. It’s the approach City of Hope is taking with its newly launched multidisciplinary teams, br...
  • It’s a reasonable question: Why is the National Cancer Institute funding a study on preventing heart failure? The answer is reasonable as well: Rates of heart failure are drastically high among childhood cancer survivors — 15 times higher than among people the same age who were never treated for cancer. T...
  • Many teenagers take a break from academics during the summer, but not the eight high school students enrolled in the California Institute for Regenerative Medicine (CIRM) Creativity Awards program at City of Hope. They took the opportunity to obtain as much hands-on research experience as possible, learning fro...
  • About one in eight women will develop breast cancer at some point in her life. In fact, breast cancer is the most common cancer in American women, behind skin cancer. Although women can’t change some risk factors, such as genetics and the natural aging process, there are certain things they can do to lower thei...
  • As genetic testing becomes more sophisticated, doctors and their patients are finding that such tests can lead to the discovery of previously unknown cancer risks. In his practice at City of Hope, Thomas Slavin, M.D., an assistant clinical professor in the Division of Clinical Cancer Genetics, sees the full spe...
  • And the winners are … everyone in the San Gabriel Valley. The recipients of City of Hope’s first-ever Healthy Living grants have been announced, and the future is looking healthier already. In selecting San Gabriel Valley organizations to receive the grants, City of Hope’s Community Benefits Advisory Council ch...
  • Barry Leshowitz is a former City of Hope patient and a family advisor for the Sheri & Les Biller Patient and Family Resource Center. It’s been almost seven years since I checked into a local hospital in Phoenix for a hip replacement, only to be informed by the surgeon that he had canceled the surgery....
  • When it comes to science, the best graduate schools don’t just train scientists, they prepare their students for a lifetime of learning, accomplishment and positive impact on society. At City of Hope, the Irell & Manella Graduate School of Biological Sciences goes one step further – by preparing students to...
  • Cancer affects not just the cancer patient, but everyone around him or her, even after treatment is complete. The challenges can include the fear of cancer recurrence, coping with cancer’s economic impact and the struggle to achieve work-life balance post-treatment. Family members and loved ones of cancer patie...
  •   Bladder cancer facts: Bladder cancer is a disease in which malignant (cancer) cells form in the tissues of the bladder. 2015 estimates: 74,000 new cases of bladder cancer diagnosed 16,000 deaths from bladder cancer (about 11,510 in men and 4,490 in women) Risk factors for bladder cancer: Smoking: Smokers...
  • Women with ovarian cancer have questions about the most promising treatment options, revolutionary research avenues, survivorship and, of course, the potential impact on their personal lives. Now, together in one place, are experts who can provide answers. On Saturday, Sept. 12, the 2015 Ovarian Cancer Survivor...