A National Cancer Institute-designated Comprehensive Cancer Center

Make an appointment: 800-826-HOPE
Molecular Oncology (MONC) Program Bookmark and Share

Molecular Oncology (MONC) Program

Emily Wang, Ph.D., Co-leader
Binghui Shen, Ph.D., Co-leader
Program Members -If you would like an updated membership list, please contact Kim Lu at kilu@coh.org.
 
The overall scientific vision of theMolecularOncologyProgram (MONC)is to investigate fundamental DNA and RNA biology for the purpose of understanding basic mechanisms of cancer and ultimately identifying potential new therapeutic approaches. The major emphasis is on understanding the biology of cancer cells, which is accomplished by investigating the development of cancer, studying the biological mechanisms of cancer development, discovering information on key targets for cancer therapy, and developing advanced technologies used in cancer research.
 
Investigations into the mechanisms of DNA damage and repair mechanisms form one foundation of this program and are relevant to cancer development. Changes in cellular gene expression that accompany tumor growth are equally important to cancer progression. Studies of DNA methylation and epigenetics represent a second strong component of the program. Investigators studying transcriptional and post-transcriptional mechanisms of gene regulation contribute yet another dimension to this program. Changes in gene expression during cancer cell progression can result in a variety of events that promote uncontrolled cellular growth. These include altered splicing patterns and disregulation of the microRNA population, both of which lead to additional alterations in gene expression. Nuclear receptors and transcription factors have traditionally been important chemotherapeutic targets; theMolecular Oncologyprogram includes a group of investigators studying these important macromolecules and their ligands.

Program Goals
  • Understand the relationship between DNA damage and repair, mutagenesis, and carcinogenesis at the molecular level.
  • Investigate the fundamental processes underlying gene regulation, epigenetics and RNA biology during cell lineage commitment and tumor formation.
 
Members' Research
Members of theMolecular OncologyProgram have expertise in diverse areas of basic cancer biology that include chromatin structure, receptor-mediated control of gene expression, regulation of transcription by tissue- and cell-specific transcription factors, small drug interactions with and modulation of DNA and RNA function, cell signaling mechanisms, regulation of RNA processing, and the use of epigenetic tools such as siRNA and ribozymes to modulate gene expression. These basic science studies provide the foundation for future development of novel approaches to cancer therapy by the DCT, CI and HM Programs.
 

Molecular Oncology (MONC) Program

Molecular Oncology (MONC) Program

Emily Wang, Ph.D., Co-leader
Binghui Shen, Ph.D., Co-leader
Program Members -If you would like an updated membership list, please contact Kim Lu at kilu@coh.org.
 
The overall scientific vision of theMolecularOncologyProgram (MONC)is to investigate fundamental DNA and RNA biology for the purpose of understanding basic mechanisms of cancer and ultimately identifying potential new therapeutic approaches. The major emphasis is on understanding the biology of cancer cells, which is accomplished by investigating the development of cancer, studying the biological mechanisms of cancer development, discovering information on key targets for cancer therapy, and developing advanced technologies used in cancer research.
 
Investigations into the mechanisms of DNA damage and repair mechanisms form one foundation of this program and are relevant to cancer development. Changes in cellular gene expression that accompany tumor growth are equally important to cancer progression. Studies of DNA methylation and epigenetics represent a second strong component of the program. Investigators studying transcriptional and post-transcriptional mechanisms of gene regulation contribute yet another dimension to this program. Changes in gene expression during cancer cell progression can result in a variety of events that promote uncontrolled cellular growth. These include altered splicing patterns and disregulation of the microRNA population, both of which lead to additional alterations in gene expression. Nuclear receptors and transcription factors have traditionally been important chemotherapeutic targets; theMolecular Oncologyprogram includes a group of investigators studying these important macromolecules and their ligands.

Program Goals
  • Understand the relationship between DNA damage and repair, mutagenesis, and carcinogenesis at the molecular level.
  • Investigate the fundamental processes underlying gene regulation, epigenetics and RNA biology during cell lineage commitment and tumor formation.
 
Members' Research
Members of theMolecular OncologyProgram have expertise in diverse areas of basic cancer biology that include chromatin structure, receptor-mediated control of gene expression, regulation of transcription by tissue- and cell-specific transcription factors, small drug interactions with and modulation of DNA and RNA function, cell signaling mechanisms, regulation of RNA processing, and the use of epigenetic tools such as siRNA and ribozymes to modulate gene expression. These basic science studies provide the foundation for future development of novel approaches to cancer therapy by the DCT, CI and HM Programs.
 
Research Shared Services

City of Hope embodies the spirit of scientific collaboration by sharing services and core facilities with colleagues here and around the world.
 

Clinical Trials
Our aggressive pursuit to discover better ways to help patients now – not years from now – places us among the leaders worldwide in the administration of clinical trials.
 
Learn more about City of Hope's institutional distinctions, breakthrough innovations and collaborations.
Discover the wide range of progressive cancer treatment options at City of Hope designed to meet the individual needs of each patient. Here, medical research and clinical care are integrated, speeding the application of scientific discoveries toward better, more effective patient cancer treatments.
City of Hope Breakthroughs
Get the latest in City of Hope's research, treatment and news you can use on our blog, Breakthroughs.
 
 
When you support City of Hope, you help us shorten the time it takes to get from bold, innovative ideas to powerful new medical treatments. Make a gift online now.


NEWS & UPDATES
  • Karen Reckamp, M.D., M.S., has an office next to my own, and we often see patients at the same time. As such, I’ve gotten to know her quite well over the years, and I’ve also gotten a glimpse of many of her patients. She specializes in lung cancer, and most of her patients have tumors […]
  • Today is National Doctors Day, the official day to recognize, thank and celebrate the tremendous work physicians do each and every day. Launched in 1991 via a presidential proclamation from then-President George Bush, the observance offers a chance to reflect on the qualities that define truly great medical car...
  • When considering cancer risk, categories like “women’s cancers” and “men’s cancers” may not matter. A complete medical history, especially of first-degree relatives, must be considered when evaluating risk. A new study drives home that fact. Published in the journal Cancer, the study found a link between a fami...
  • Precision medicine holds promise – on that doctors, especially cancer specialists, can agree. But this sophisticated approach to treatment, which incorporates knowledge about a person’s genetic profile, environment and lifestyle, isn’t yet standard for all cancers. It can’t be. Researchers and scientists are st...
  • Frank Di Bella, 70, is on a mission: Find a cure for metastatic bladder cancer. It’s just possible he might. Although Di Bella isn’t a world-renowned physician, cancer researcher or scientist, he knows how to make things happen. For more than 20 years, he served as chairman of annual fundraising gal...
  • The physical side effects of cancer can damage anyone’s self-confidence, but especially that of women who, rightly or wrongly, are more likely to find their appearance (or their own perception of their appearance) directly connected to their ability to face the world with something resembling aplomb. Furt...
  • The promise of stem cell therapy has long been studied in laboratories. Now, as medicine enters an era in which this therapy will be increasingly available to patients, the nurses who help deliver it will be in the spotlight. City of Hope, which has launched its Alpha Clinic for Cell Therapy and Innovation (ACT...
  • Just because you can treat a condition, such as high cholesterol, at the end of life — well, that doesn’t mean you should. That’s the basic lesson of a study to be published March 30 in JAMA Internal Medicine. The ramifications go far beyond that. The research, in which City of Hope’s Betty Fe...
  • The understanding of the relationship between genetics and cancer risk continues to grow, with more genetic testing than ever before available to patients. However, the adage that a little knowledge is a dangerous thing is applicable: Without context for what a test result means, and without meaningful guidance...
  • Standard prostate biopsies haven’t changed significantly in the past 30 years – nor have the problems inherent with them. Regular biopsies have an expected error rate: Tumors may potentially be undersampled and, 30 percent of the time, men who undergo a radical prostatectomy are found to have more aggress...
  • In the field of cancer, patients have had surgery, chemotherapy and radiation therapy as options. Now, as City of Hope officially opens the Alpha Clinic for Cellular Therapy and Innovation, patients battling cancer and other life-threatening diseases have another option: stem-cell-based therapy. The Alpha Clini...
  • How does the environment affect our health? Specifically, how does it affect our risk of cancer? City of Hope physicians and researchers recently answered those questions in an Ask the Experts event in Corona, California, explaining the underlying facts about how the environment can affect our health. Moderator...
  • Nurses and other medical professionals have come to understand that it’s not enough just to fight disease. They also must provide pain relief, symptom control, and an unrelenting commitment to improve patients’ quality of life — especially at the end of life. Not too long ago, this was a relatively ...
  • “Tonight, I’m launching a new precision medicine initiative to bring us closer to curing diseases like cancer.” These were the words of President Barack Obama on Jan. 20, 2015, during his State of the Union address. So what is precision medicine, and how close are we to making it a reality for...
  • March is Colon Cancer Awareness Month. How sad, yet how serendipitous, that the co-creator of “The Simpsons” Sam Simon passed away in March after a four-year battle against colon cancer. What message can we all learn from his illness that can help us prevent and overcome colon cancer in our own lives? Colon can...