A National Cancer Institute-designated Comprehensive Cancer Center

Make an appointment: 800-826-HOPE
BMT Study Bookmark and Share

HOME / WELCOME

BMT Long-term Follow-up Study

The Blood or Marrow Transplant Long-term Follow-up Study (BMT Long-term Follow-up Study) is a collaborative research effort between the City of Hope (COH) and University of Minnesota (UMN). This study began in 2000 and was initially funded by a grant from the National Cancer Institute. The original BMT Long-term Follow-up Study cohort consisted of over 2500 individuals who had received blood or marrow transplantation (BMT) at COH or UMN between 1974 and 1998. Now, with funding from the Leukemia Lymphoma Society, the BMT Long-term Follow-up Study cohort is being expanded to include about 7500 children and adults who underwent BMT at COH or UMN between 1974 and 2010, and survived at least two years. The expansion study will also enroll 1500 siblings to serve as the comparison group. The BMT Long-term Follow-up Study, assembled through the efforts of the investigators at COH and UMN, will be the largest undertaking of its kind. It will be coordinated through City of Hope, in Duarte, CA.
 
BMT is used with curative intent for many life-threatening illnesses. Over 70% of those who survive the first two years after BMT become long-term survivors. The BMT Long-term Follow-up Study examines detailed information regarding the long-term health of those treated with BMT. However, researchers have not yet followed such patients long enough to understand the very long-term issues faced by these patients. The importance of this study encompasses the long-term well-being of the transplant survivor, and the practice of the physician. For the transplant team, knowledge of late effects of therapy is critical in choosing initial therapy for patients, as well as in planning appropriate follow-up of survivors. A more thorough understanding of post-BMT complications could result in a more effective use of prevention strategies after transplant, a potential reduction in possible complications after BMT and decreased cost for patients’ care.
 

Biopathology

 
COH and UMN have collaborated in an effort to understand the long-term health of persons treated with a blood or marrow transplant. We are studying the risk of long-term side effects of BMT, and the molecular underpinnings of these complications. The Expanded BMT Long-term Follow-up Study will be collecting specimens from all patients and sibling participants to carry out these aims. The hope is to more fully understand the molecular basis of the complications so as to predict potential complications after BMT. The data will put us on the path toward being able to identify specific biomarkers and to give personalized treatment to address those effects. To that end, we will be collecting samples of saliva, cheek cells, fingernails and toenails, or blood to pinpoint and isolate relevant biomarkers.

Understanding the morphological and/or molecular structures involved will enable clinicians to perform better and targeted care to specific tumors. COH and UMN researchers will then use the information collected as part of its therapeutic arsenal to make recommendations for the treatment and follow-up of future patients treated with BMT.
 

Expanded Study

The original BMT Long-term Follow-up Study is undergoing expansion (by including patients transplanted up to 2010) and extended (with longer follow-up of the original cohort of patients) to form the Expanded BMT Long-term Follow-up Study. This study will continue to examine the health and well-being of individuals undergoing BMT, extend the length of follow-up after transplant, and, by collecting biological samples, pinpoint potential molecular markers that will allow us to dispense appropriate, timely and risk-based preventive care to help ease the late effects of therapy.
 
The Expanded Blood or Marrow Transplant Long-term Follow-up Study endeavors to:
  • Understand the long-term health issue faced by patients undergoing BMT
  • Describe the burden of morbidity borne by patients undergoing BMT and compare with age- and sex-matched siblings
  • Describe health risk behaviors and healthcare utilization by HCT survivors and compare with age- and sex-matched siblings
  • Describe risk of long-term complications in individuals undergoing BMT
  • Create a repository of DNA for future study to identify/determine who is at highest risk for long-term complications, and how best to treat these conditions.

Blood or Marrow Transplants are frequently offered to patients suffering from leukemia, lymphoma, multiple myeloma and other diseases. As research and techniques have improved, the number of patients who survive such treatments has dramatically increased such that now over 70% of patients who survive the first two years after transplant become long-term survivors. Still, BMT recipients often have an increased risk for long-term complications such as heart disease, lung problems, bone problems or other new cancers. Research has yet to fully understand these long-term problems that affect transplant patients, yet appropriate, timely and risk-based preventive care may help attenuate some late effects of such therapy.
 
Previous studies in BMT patients have been limited by a number of complicating factors:
 
  • reliance on incomplete or inadequate registry data
  • failure to examine other factors that may have affected post-HCT complications (misdiagnosis)
  • inability to track patients for extended periods of time to wholly understand complications
  • lack of biological specimens to study individual differences at the molecular level that affect risk of complications.

The Expanded BMT Long-term Follow-up Study will be the largest study of its kind. We aim to study about 7500 children and adults who have undergone BMT at City of Hope or University of Minnesota between 1974 and 2010. We will also enroll 1500 siblings to serve as a comparison group. The inclusion of siblings will allow investigators to make direct comparisons with survivors providing baseline non-BMT data that may be lacking from other sources. Additionally, the use of siblings may enable us to identify potential factors that may be associated with the development of long-term complications and understand more fully the molecular basis for the complications.
 

HealthyLiving

It is important to maintain a healthy lifestyle which includes eating healthily, being physically active and taking safety precautions throughout one’s daily life. Along with these simple guidelines (below) the following websites have useful information to help you accomplish your post-cancer goals.
 
Diet and Exercise:
Proper nutrition and exercise are important for good health
Eat a healthy diet each day:
 
  • Eat high calcium food (milk products including yogurt, cheese, and dark green vegetables (such as broccoli)
  • Eat low-fat food
  • Five or more servings of fruit and vegetables
  • High fiber food (whole grain bread, pasts, cereal, rice, etc.)
  • Choose fish, turkey, chicken, and beans; limit red meats
  • Limit fried food, high sugar foods, and candy
 
Maintain healthy weight
Exercise regularly
 
Healthy living:
Healthy habits and regular health care check-ups are important for good health
 
  • Get regular health care check-ups
  • Use sunscreen
  • Avoid second hand smoke and do not smoke or use other tobacco products
  • Avoid taking medicines that you don’t need
  • Do not drink alcohol or use illicit drugs
  • Wear seatbelt when riding or driving a car
  • Do not ride in the front seat of a car if you are less than 12 years old
  • Ride in a car seat until 40 pounds (18 kgs)
  • Use a booster seat until age 6 years old or 60 pounds (27 kgs), whichever occurs last
  • Wear a helmet, elbow and knee pads when skateboarding or rollerblading
  • Wear a helmet when riding a bike
 

Original BMT Study

BMT Study
 
City of Hope and University of Minnesota researchers initially assembled a group of ~2500 subjects who had undergone BMT between 1974 and 1998 and survived two or more years. Findings from this study helped describe the health (both physical and psychological) of individuals who had received BMT during childhood or as adults. Specifically, this study described the long-term term survival after BMT, the health of patients who had received BMT for chronic myeloid leukemia, non-Hodgkin lymphoma, acute lymphoblastic leukemia and acute myeloid leukemia. The study was also able to describe the health care utilization by long-term survivors, and their health habits. Finally, the study was able to describe the overall burden of morbidity borne by individuals receiving BMT.

Publications

 
 
Some of the publications resulting from the original BMT Long-term Follow-up Study include:
 
1. Louie A, Robison LL, Bogue M, Hyde S, Forman SJ, Bhatia S. Validation of self-reported complications by bone marrow transplantation survivors. Bone Marrow Transplant. 2000;25:1191-1196.

http://www.ncbi.nlm.nih.gov/pubmed/10849532
 
2. Baker KS, Gurney JG, Ness KK, Bhatia R, Forman SJ, Francisco L, McGlave PB, Robison LL, Snyder DS, Weisdorf DJ, Bhatia S. Late effects in survivors of chronic myeloid leukemia treated with hematopoietic cell transplantation: results from BMTSS. Blood. 2004;104:1898-1906.
 
 
3. Bhatia S, Robison LL, Francisco L, Carter A, Liu Y, Grant M, Baker KS, Fung H, Gurney JG, McGlave PB, Nademanee A, ramsay NK, Stein A, Weisdorf DJ, Forman SJ. Late Mortality in survivors of autologous hematopoietic cell transplantation: report from the BMTSS. Blood. 2005;105:4215-22.
 
 
4. Ness KK, Bhatia S, Baker KS, Francisco L, Carter A, Forman SJ, Robison LL, Rosenthal J, Gurney JG. Performance limitations and participation restrictions among childhood cancer survivors treated with hematopoietic stem cell transplantation: the BMTSS. Arch Pediatr Adolesc Med. 2005;159:706-13.
 
 
5. Gurney JG, Ness KK, Rosenthal J, Forman SJ, Bhatia D, Baker KS. Visual, auditory, sensory, and motor impairments in long-term survivors of hematopoietic stem cell transplantation performed in childhood: reports from the BMTSS. Cancer. 2006;106:1402-8.
 
 
6. Carter A, Robison LL, Francisco L, Smith D, Grant M, Baker KS, Gurney JG, McGlave PB, Weisdorf DJ, Forman SJ, Bhatia S. Prevalence of conception and pregnancy outcomes after hematopoietic cell transplantation: report from the BMTSS. Bone Marrow Transplant. 2006;37:1023-9.
 
 
7. Fraser CJ, Bhatia S, Ness K, Carter A, Francisco L, Arora M, Parker P, Forman S, Weisdorf D, Gurney JG, Baker KS. Impact of chronic graft-versus-host disease on the health status of hematopoietic cell transplantation survivors: a report from BMTSS. Blood. 2006;108:2867-2873.
 
 
8. Baker KS, Ness K, Steinberger J, Carter A, Francisco L, Burns LJ, Sklar C, Forman S, Weisdorf D, Gurney JG, Bhatia S. Diabetes, hypertension and cardiovascular events in survivors of hematopoietic cell transplantation: A report from the BMTSS. Blood. 2007;109:1765-1772.
 
 
9. Shankar S, Carter A, Sun CL, Francisco L, Baker KS, Gurney JG, Weisdorf DG, Forman SJ, Robison LL, Grant M, Bhatia S. Health Care Utilization by adult long-term survivors of hematopoietic cell transplant: Report from the BMTSS. Cancer Epidemiol Biomarkers Prev. 2007;16:834-839.
 
 
10. Majhail NS, Ness KK, Burns LJ, Sun CL, Carter A, Francisco L, Forman SJ, Bhatia S, Baker KS. Late Effects in Survivors of Hodgkin and non-Hodgkin lymphoma treated with autologous hematopoietic cell transplantation: a report from the BMTSS. Biol Blood Marrow Transplant. 2007;13:1153-9.
 
 
11. Bhatia S, Francisco L, Carter A, Sun CL, Baker KS, Gurney JG, McGlave PB, Nademanee A, O'Donnell M, Ramsay NK, Robison LL, Snyder D, Stein A, Forman SJ, Weisdorf DJ. Late mortality after allogeneic hematopoietic cell transplantation and functional status of long-term survivors. Report from the BMTSS. Blood. 2007;110:3784-3792.
 
 
12. Prasad PK, Sun CL, Baker KS, Francisco L, Forman S, Bhatia S. Healthcare utilization by adult Hispanic long-term survivors of hematopoietic stem cell transplantation: report from the BMTSS. Cancer. 2008;113:2724-33.
 
 
13. Armenian SH, Sun CL, Teh JB, Arora M, Baker KS, Francisco L, Forman SJ, Bhatia S. Ethnic differences in chronic health conditions after hematopoietic cell transplantation: a report from the BMTSS. Cancer 2010;116:4152-9.
 
 
14. Sun CL, Francisco L, Kawashima T, Leisenring W, Robison LL, Baker KS, Weisdorf DJ, Forman SJ, Bhatia S. Prevalence and Predictors of Chronic Health Conditions after Hematopoietic Cell Transplantation: A report from the BMTSS. Blood. 2010;116:3129-3139.
 
 
15. Baker KS, Ness KK, Weisdorf D, Francisco L, Sun CL, Forman SJ, Bhatia S. Late effects in survivors of acute leukemia treated with hematopoietic cell transplantation: a report from the Bone Marrow Transplant Survivor Study. Leukemia. 2010; 24:2039-47.
 
 
16. Armenian S, Sun CL, Kawashima T, Arora M, Leisenring W, Sklar CA, Baker KS, Francisco L, Teh JB, Mills G, Wong FL, Rosenthal J, Diller LR, Hudson MM, Oeffinger KC, Forman SJ, Robison LL, Bhatia S. Long-term health-related outcomes in survivors of childhood cancer treated with HCT versus conventional therapy: A report from BMTSS and CCSS. Blood. 2011;118:1413-20.
 
 
17. Sun CL, Francisco L, Baker KS, Weisdorf DJ, Forman SJ, Bhatia S. Adverse Psychological Outcomes in Long-term Survivors of HCT. Blood. 2011;118:4723-31.
 
 
18. Armenian SH, Sun CL, Francisco L, Baker KS, Weisdorf DJ, Forman SJ, Bhatia S. Health behaviors and cancer screening practices in long-term survivors of HCT: A report from the BMTSS. Bone Marrow Transplantation. 2012;47:283-290.
 
 
19. Vanderwalde AM, Sun CL, Laddaran L, Francisco L, Armenian S, Berano-Teh J, Wong FL, Popplewell L, Somlo G, Stein AS, Nademanee A, Krishnan A, Kogut N, Forman SJ, Bhatia S. Conditional survival and cause-specific mortality after autologous hematopoietic cell transplantation for hematological malignancies. Leukemia. 2012 Nov 7. doi: 10.1038/leu.2012.311.
 
 

Contact Us

Blood or Marrow Transplant Long-term Follow-up Study City of Hope
1500 East Duarte Road
Duarte, CA 91010
 
www.BMTStudy.com
bmtstudy@coh.org
toll free: (866) 242-1356
 
Principal Investigators:
Dr. Smita Bhatia, City of Hope
Dr. Mukta Arora, University of Minnesota
 

BMT Study

HOME / WELCOME

BMT Long-term Follow-up Study

The Blood or Marrow Transplant Long-term Follow-up Study (BMT Long-term Follow-up Study) is a collaborative research effort between the City of Hope (COH) and University of Minnesota (UMN). This study began in 2000 and was initially funded by a grant from the National Cancer Institute. The original BMT Long-term Follow-up Study cohort consisted of over 2500 individuals who had received blood or marrow transplantation (BMT) at COH or UMN between 1974 and 1998. Now, with funding from the Leukemia Lymphoma Society, the BMT Long-term Follow-up Study cohort is being expanded to include about 7500 children and adults who underwent BMT at COH or UMN between 1974 and 2010, and survived at least two years. The expansion study will also enroll 1500 siblings to serve as the comparison group. The BMT Long-term Follow-up Study, assembled through the efforts of the investigators at COH and UMN, will be the largest undertaking of its kind. It will be coordinated through City of Hope, in Duarte, CA.
 
BMT is used with curative intent for many life-threatening illnesses. Over 70% of those who survive the first two years after BMT become long-term survivors. The BMT Long-term Follow-up Study examines detailed information regarding the long-term health of those treated with BMT. However, researchers have not yet followed such patients long enough to understand the very long-term issues faced by these patients. The importance of this study encompasses the long-term well-being of the transplant survivor, and the practice of the physician. For the transplant team, knowledge of late effects of therapy is critical in choosing initial therapy for patients, as well as in planning appropriate follow-up of survivors. A more thorough understanding of post-BMT complications could result in a more effective use of prevention strategies after transplant, a potential reduction in possible complications after BMT and decreased cost for patients’ care.
 

Biopathology

Biopathology

 
COH and UMN have collaborated in an effort to understand the long-term health of persons treated with a blood or marrow transplant. We are studying the risk of long-term side effects of BMT, and the molecular underpinnings of these complications. The Expanded BMT Long-term Follow-up Study will be collecting specimens from all patients and sibling participants to carry out these aims. The hope is to more fully understand the molecular basis of the complications so as to predict potential complications after BMT. The data will put us on the path toward being able to identify specific biomarkers and to give personalized treatment to address those effects. To that end, we will be collecting samples of saliva, cheek cells, fingernails and toenails, or blood to pinpoint and isolate relevant biomarkers.

Understanding the morphological and/or molecular structures involved will enable clinicians to perform better and targeted care to specific tumors. COH and UMN researchers will then use the information collected as part of its therapeutic arsenal to make recommendations for the treatment and follow-up of future patients treated with BMT.
 

Expanded Study

Expanded Study

The original BMT Long-term Follow-up Study is undergoing expansion (by including patients transplanted up to 2010) and extended (with longer follow-up of the original cohort of patients) to form the Expanded BMT Long-term Follow-up Study. This study will continue to examine the health and well-being of individuals undergoing BMT, extend the length of follow-up after transplant, and, by collecting biological samples, pinpoint potential molecular markers that will allow us to dispense appropriate, timely and risk-based preventive care to help ease the late effects of therapy.
 
The Expanded Blood or Marrow Transplant Long-term Follow-up Study endeavors to:
  • Understand the long-term health issue faced by patients undergoing BMT
  • Describe the burden of morbidity borne by patients undergoing BMT and compare with age- and sex-matched siblings
  • Describe health risk behaviors and healthcare utilization by HCT survivors and compare with age- and sex-matched siblings
  • Describe risk of long-term complications in individuals undergoing BMT
  • Create a repository of DNA for future study to identify/determine who is at highest risk for long-term complications, and how best to treat these conditions.

Blood or Marrow Transplants are frequently offered to patients suffering from leukemia, lymphoma, multiple myeloma and other diseases. As research and techniques have improved, the number of patients who survive such treatments has dramatically increased such that now over 70% of patients who survive the first two years after transplant become long-term survivors. Still, BMT recipients often have an increased risk for long-term complications such as heart disease, lung problems, bone problems or other new cancers. Research has yet to fully understand these long-term problems that affect transplant patients, yet appropriate, timely and risk-based preventive care may help attenuate some late effects of such therapy.
 
Previous studies in BMT patients have been limited by a number of complicating factors:
 
  • reliance on incomplete or inadequate registry data
  • failure to examine other factors that may have affected post-HCT complications (misdiagnosis)
  • inability to track patients for extended periods of time to wholly understand complications
  • lack of biological specimens to study individual differences at the molecular level that affect risk of complications.

The Expanded BMT Long-term Follow-up Study will be the largest study of its kind. We aim to study about 7500 children and adults who have undergone BMT at City of Hope or University of Minnesota between 1974 and 2010. We will also enroll 1500 siblings to serve as a comparison group. The inclusion of siblings will allow investigators to make direct comparisons with survivors providing baseline non-BMT data that may be lacking from other sources. Additionally, the use of siblings may enable us to identify potential factors that may be associated with the development of long-term complications and understand more fully the molecular basis for the complications.
 

HealthyLiving

HealthyLiving

It is important to maintain a healthy lifestyle which includes eating healthily, being physically active and taking safety precautions throughout one’s daily life. Along with these simple guidelines (below) the following websites have useful information to help you accomplish your post-cancer goals.
 
Diet and Exercise:
Proper nutrition and exercise are important for good health
Eat a healthy diet each day:
 
  • Eat high calcium food (milk products including yogurt, cheese, and dark green vegetables (such as broccoli)
  • Eat low-fat food
  • Five or more servings of fruit and vegetables
  • High fiber food (whole grain bread, pasts, cereal, rice, etc.)
  • Choose fish, turkey, chicken, and beans; limit red meats
  • Limit fried food, high sugar foods, and candy
 
Maintain healthy weight
Exercise regularly
 
Healthy living:
Healthy habits and regular health care check-ups are important for good health
 
  • Get regular health care check-ups
  • Use sunscreen
  • Avoid second hand smoke and do not smoke or use other tobacco products
  • Avoid taking medicines that you don’t need
  • Do not drink alcohol or use illicit drugs
  • Wear seatbelt when riding or driving a car
  • Do not ride in the front seat of a car if you are less than 12 years old
  • Ride in a car seat until 40 pounds (18 kgs)
  • Use a booster seat until age 6 years old or 60 pounds (27 kgs), whichever occurs last
  • Wear a helmet, elbow and knee pads when skateboarding or rollerblading
  • Wear a helmet when riding a bike
 

Original BMT Study

Original BMT Study

BMT Study
 
City of Hope and University of Minnesota researchers initially assembled a group of ~2500 subjects who had undergone BMT between 1974 and 1998 and survived two or more years. Findings from this study helped describe the health (both physical and psychological) of individuals who had received BMT during childhood or as adults. Specifically, this study described the long-term term survival after BMT, the health of patients who had received BMT for chronic myeloid leukemia, non-Hodgkin lymphoma, acute lymphoblastic leukemia and acute myeloid leukemia. The study was also able to describe the health care utilization by long-term survivors, and their health habits. Finally, the study was able to describe the overall burden of morbidity borne by individuals receiving BMT.

Publications

Publications

 
 
Some of the publications resulting from the original BMT Long-term Follow-up Study include:
 
1. Louie A, Robison LL, Bogue M, Hyde S, Forman SJ, Bhatia S. Validation of self-reported complications by bone marrow transplantation survivors. Bone Marrow Transplant. 2000;25:1191-1196.

http://www.ncbi.nlm.nih.gov/pubmed/10849532
 
2. Baker KS, Gurney JG, Ness KK, Bhatia R, Forman SJ, Francisco L, McGlave PB, Robison LL, Snyder DS, Weisdorf DJ, Bhatia S. Late effects in survivors of chronic myeloid leukemia treated with hematopoietic cell transplantation: results from BMTSS. Blood. 2004;104:1898-1906.
 
 
3. Bhatia S, Robison LL, Francisco L, Carter A, Liu Y, Grant M, Baker KS, Fung H, Gurney JG, McGlave PB, Nademanee A, ramsay NK, Stein A, Weisdorf DJ, Forman SJ. Late Mortality in survivors of autologous hematopoietic cell transplantation: report from the BMTSS. Blood. 2005;105:4215-22.
 
 
4. Ness KK, Bhatia S, Baker KS, Francisco L, Carter A, Forman SJ, Robison LL, Rosenthal J, Gurney JG. Performance limitations and participation restrictions among childhood cancer survivors treated with hematopoietic stem cell transplantation: the BMTSS. Arch Pediatr Adolesc Med. 2005;159:706-13.
 
 
5. Gurney JG, Ness KK, Rosenthal J, Forman SJ, Bhatia D, Baker KS. Visual, auditory, sensory, and motor impairments in long-term survivors of hematopoietic stem cell transplantation performed in childhood: reports from the BMTSS. Cancer. 2006;106:1402-8.
 
 
6. Carter A, Robison LL, Francisco L, Smith D, Grant M, Baker KS, Gurney JG, McGlave PB, Weisdorf DJ, Forman SJ, Bhatia S. Prevalence of conception and pregnancy outcomes after hematopoietic cell transplantation: report from the BMTSS. Bone Marrow Transplant. 2006;37:1023-9.
 
 
7. Fraser CJ, Bhatia S, Ness K, Carter A, Francisco L, Arora M, Parker P, Forman S, Weisdorf D, Gurney JG, Baker KS. Impact of chronic graft-versus-host disease on the health status of hematopoietic cell transplantation survivors: a report from BMTSS. Blood. 2006;108:2867-2873.
 
 
8. Baker KS, Ness K, Steinberger J, Carter A, Francisco L, Burns LJ, Sklar C, Forman S, Weisdorf D, Gurney JG, Bhatia S. Diabetes, hypertension and cardiovascular events in survivors of hematopoietic cell transplantation: A report from the BMTSS. Blood. 2007;109:1765-1772.
 
 
9. Shankar S, Carter A, Sun CL, Francisco L, Baker KS, Gurney JG, Weisdorf DG, Forman SJ, Robison LL, Grant M, Bhatia S. Health Care Utilization by adult long-term survivors of hematopoietic cell transplant: Report from the BMTSS. Cancer Epidemiol Biomarkers Prev. 2007;16:834-839.
 
 
10. Majhail NS, Ness KK, Burns LJ, Sun CL, Carter A, Francisco L, Forman SJ, Bhatia S, Baker KS. Late Effects in Survivors of Hodgkin and non-Hodgkin lymphoma treated with autologous hematopoietic cell transplantation: a report from the BMTSS. Biol Blood Marrow Transplant. 2007;13:1153-9.
 
 
11. Bhatia S, Francisco L, Carter A, Sun CL, Baker KS, Gurney JG, McGlave PB, Nademanee A, O'Donnell M, Ramsay NK, Robison LL, Snyder D, Stein A, Forman SJ, Weisdorf DJ. Late mortality after allogeneic hematopoietic cell transplantation and functional status of long-term survivors. Report from the BMTSS. Blood. 2007;110:3784-3792.
 
 
12. Prasad PK, Sun CL, Baker KS, Francisco L, Forman S, Bhatia S. Healthcare utilization by adult Hispanic long-term survivors of hematopoietic stem cell transplantation: report from the BMTSS. Cancer. 2008;113:2724-33.
 
 
13. Armenian SH, Sun CL, Teh JB, Arora M, Baker KS, Francisco L, Forman SJ, Bhatia S. Ethnic differences in chronic health conditions after hematopoietic cell transplantation: a report from the BMTSS. Cancer 2010;116:4152-9.
 
 
14. Sun CL, Francisco L, Kawashima T, Leisenring W, Robison LL, Baker KS, Weisdorf DJ, Forman SJ, Bhatia S. Prevalence and Predictors of Chronic Health Conditions after Hematopoietic Cell Transplantation: A report from the BMTSS. Blood. 2010;116:3129-3139.
 
 
15. Baker KS, Ness KK, Weisdorf D, Francisco L, Sun CL, Forman SJ, Bhatia S. Late effects in survivors of acute leukemia treated with hematopoietic cell transplantation: a report from the Bone Marrow Transplant Survivor Study. Leukemia. 2010; 24:2039-47.
 
 
16. Armenian S, Sun CL, Kawashima T, Arora M, Leisenring W, Sklar CA, Baker KS, Francisco L, Teh JB, Mills G, Wong FL, Rosenthal J, Diller LR, Hudson MM, Oeffinger KC, Forman SJ, Robison LL, Bhatia S. Long-term health-related outcomes in survivors of childhood cancer treated with HCT versus conventional therapy: A report from BMTSS and CCSS. Blood. 2011;118:1413-20.
 
 
17. Sun CL, Francisco L, Baker KS, Weisdorf DJ, Forman SJ, Bhatia S. Adverse Psychological Outcomes in Long-term Survivors of HCT. Blood. 2011;118:4723-31.
 
 
18. Armenian SH, Sun CL, Francisco L, Baker KS, Weisdorf DJ, Forman SJ, Bhatia S. Health behaviors and cancer screening practices in long-term survivors of HCT: A report from the BMTSS. Bone Marrow Transplantation. 2012;47:283-290.
 
 
19. Vanderwalde AM, Sun CL, Laddaran L, Francisco L, Armenian S, Berano-Teh J, Wong FL, Popplewell L, Somlo G, Stein AS, Nademanee A, Krishnan A, Kogut N, Forman SJ, Bhatia S. Conditional survival and cause-specific mortality after autologous hematopoietic cell transplantation for hematological malignancies. Leukemia. 2012 Nov 7. doi: 10.1038/leu.2012.311.
 
 

Contact Us

Contact Us

Blood or Marrow Transplant Long-term Follow-up Study City of Hope
1500 East Duarte Road
Duarte, CA 91010
 
www.BMTStudy.com
bmtstudy@coh.org
toll free: (866) 242-1356
 
Principal Investigators:
Dr. Smita Bhatia, City of Hope
Dr. Mukta Arora, University of Minnesota
 
NEWS & UPDATES
  • Brain tumors are exceptionally difficult to treat. They can be removed surgically, but individual cancer cells may have already spread elsewhere in the brain and can escape the effects of both radiation and chemotherapy. To prevent tumors from recurring, doctors need a way to find and stop those invasive cancer...
  • Breast cancer risk is personal; breast cancer risk assessment should be, too. To that end, City of Hope researchers have developed a starting point to help women (and their doctors) with a family history of the disease begin that risk assessment process. The result is an iPhone app, called BRISK, for Breast Can...
  • When it comes to breast cancer, women aren’t limited to getting screened and, if diagnosed, making appropriate treatment choices. They can also take a proactive stance in the fight against breast cancer by understanding key risk factors and practicing lifestyle habits that can help reduce their own breast...
  • Cancers of the blood and immune system are considered to be among the most difficult-to-treat cancers. A world leader in the treatment of blood cancers, City of Hope is now launching an institute specifically focused on treating people with lymphoma, leukemia and myeloma, as well as other serious blood and bone...
  • Genetics, genes, genome, genetic risk … Such terms are becoming increasingly familiar to even nonresearchers as studies and information about the human make-up become more extensive and more critical. At City of Hope, these words have long been part of our vocabulary. Researchers and physicians are studyi...
  • Mammograms are currently the best method to detect breast cancer early, when it’s easier to treat and before it’s big enough to feel or cause symptoms. But recent mammogram screening guidelines may have left some women confused about when to undergo annual testing. Here Lusi Tumyan, M.D., chief of t...
  • Although chemotherapy can be effective in treating cancer, it can also exact a heavy toll on a patient’s health. One impressive alternative researchers have found is in the form of a vaccine. A type of immunotherapy, one part of the vaccine primes the body to react strongly against a tumor; the second part dire...
  • The breast cancer statistic is attention-getting: One in eight women will be diagnosed with breast cancer during her lifetime. That doesn’t mean that, if you’re one of eight women at a dinner table, one of you is fated to have breast cancer (read more on that breast cancer statistic), but it does mean that the ...
  • Rob Darakjian was diagnosed with acute lymphoblastic leukemia at just 19 years old. He began chemotherapy and was in and out of the hospital for four months. After his fourth round of treatment, he received a bone marrow transplantation from an anonymous donor. Today, he’s cancer free. In his first post, ...
  • Advanced age tops the list among breast cancer risk factor for women. Not far behind is family history and genetics. Two City of Hope researchers delving deep into these issues recently received important grants to advance their studies. Arti Hurria, M.D., director of the Cancer and Aging Research Program, and ...
  • City of Hope is extending the reach of its lifesaving mission well beyond U.S. borders. To that end, three distinguished City of Hope leaders visited China earlier this year to lay the foundation for the institution’s new International Medicine Program. The program is part of City of Hope’s strategi...
  • A hallmark of cancer is that it doesn’t always limit itself to a primary location. It spreads. Breast cancer and lung cancer in particular are prone to spread, or metastasize, to the brain. Often the brain metastasis isn’t discovered until years after the initial diagnosis, just when patients were beginning to ...
  • Blueberries, cinnamon, baikal scullcap, grape seed extract (and grape skin extract), mushrooms, barberry, pomegranates … all contain compounds with the potential to treat, or prevent, cancer. Scientists at City of Hope have found tantalizing evidence of this potential and are determined to explore it to t...
  • Most women who are treated for breast cancer with a mastectomy do not choose to undergo reconstructive surgery. The reasons for this, according to a recent JAMA Surgery study, vary. Nearly half say they do not want any additional surgery, while nearly 34 percent say breast cancer reconstruction simply isn’t imp...
  • The leading risk factor for breast cancer is simply being a woman. The second top risk factor is getting older. Obviously, these two factors cannot be controlled, which is why all women should be aware of their risk and how to minimize those risks. Many risk factors can be mitigated, and simple changes can lead...