A National Cancer Institute-designated Comprehensive Cancer Center

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Research Overview

Research pioneered at City of Hope and its renowned Beckman Research Institute has improved the lives of men, women and children throughout the world.
 
Our reputation for scientific excellence – for fundamentally advancing the world’s understanding of cancer, diabetes, HIV/AIDS and other life-threatening diseases – stems from our determination to aggressively pursue lines of inquiry outside traditional paradigms.
 
As an independent biomedical, treatment and education center, we have the infrastructure and collaborative energy to move from bold, innovative concept to powerful new treatment swiftly. 
 
  • We are a national leader in translational research, where ideas continuously flow between investigators and clinicians.
     
  • City of Hope has not one but three on-site manufacturing facilities that enable investigators to manufacture promising new therapies without the high cost and delays encountered by other research centers.
     
  • Many of our clinical research breakthroughs have transformed the landscape of modern medicine. We helped launch the biotech industry with the development of technologies that led to the first synthetic human insulin and human growth hormone.
     
  • Our research also made possible the widely used cancer fighting drugs, Herceptin, Rituxan and Avastin.
     
  • City of Hope has more than 200 patents. At any given time, we have more than 30 investigational new drug applications. These numbers are exceptionally large for an organization of City of Hope’s size, reflecting our commitment to innovation and speeding treatments to patients
     
Discoveries happen at City of Hope because we foster an environment that supports intellectual creativity and freedom – the kind of thinking that enables us to redefine the future of medical research and medicine.


The first of only five Beckman Research Institutes established by funding from the Arnold and Mabel Beckman Foundation, we are responsible for fundamentally expanding the world’s understanding of how biology affects diseases such as cancer, HIV/AIDS and diabetes. Our breakthroughs in the areas of recombinant DNA technology, gene therapy and monoclonal antibodies are testaments to the culture of collaboration that inspires and informs our work.  Departments and divisions include:  Cancer Biology, Cancer Immunotherapeutics & Tumor Immunology, Diabetes and Metabolic Diseases Research (Division of Molecular Diabetes Research and Division of Developmental and Translational Diabetes and Endocrine Research), Immunology, Molecular and Cellular Biology, Molecular Medicine, Molecular Pharmacology, Neurosciences, Population Sciences (Division of Cancer Etiology, Division of Clinical Cancer Genetics, Division of Outcomes Research, Center for Cancer Survivorship, Division of Nursing Research and Education), Radiation Biology, Virology (Translational Vaccine Research).
 

City of Hope is one of only 41 Comprehensive Cancer Centers in the country, the highest designation awarded by the National Cancer Institute to institutions that lead the way in cancer research, treatment, prevention and education. Our five Cancer Center Research Programs run the gamut from basic and translational studies, which begin in our Molecular Oncology (MONC) and Developmental Cancer Therapeutics (DCT) Programs, to Phase I and II clinical protocols in all three clinical programs -  DCT, Cancer Immunotherapeutics (CI), and Hematologic Malignancies (HM) - and follow-up studies in survivorship and symptom management in the Cancer Control and Population Sciences (CCPS).
 
Clinical Research

From clinical trials of drugs and treatments, to studies on cancer survivorship, our multidisciplinary teams of basic, clinical and population science investigators collaborate on improving the lives of patients throughout the world.
 
  • Clinical Trials - Clinical trials, research studies that involve volunteer patients, are a crucial component to developing new, more effective treatments that save lives. Many of today’s standard therapies are based on the results of previous trials, some of which were initiated at City of Hope.
  • Phase I Clinical Trials Program - City of Hope investigates new and experimental cancer medicines, novel treatment combinations and other therapeutic methods through its Phase I Clinical Trials Program. The program offers patients access to some of the most advanced treatments in their earliest stages of development.
  • Diabetes, Endocrinology & Metabolism - From leading collaborative research programs in islet transplantation, engineering and immunology to developing therapies that control complications, this division is recognized nationwide for its innovative approaches to diabetes care.
  • Hematopoietic Stem Cell and Leukemia Research - A pioneer in bone marrow transplantation, this division is part of one of the largest, most successful bone marrow and stem cell transplantation programs of its kind in the world and continues to refine the science of transplantation. The focus of the division is to improve the understanding of leukemia stem cells in order to develop cures for leukemia and other hematologic malignancies.
  • Medical Oncology and Therapeutics Research - The Department of Medical Oncology and Therapeutics Research focuses on the treatment and prevention of solid tumors.
  • Pathology - Recognized worldwide for its diagnostic excellence, the Department of Pathology is led by renowned investigators and equipped with the most advanced technologies available.
  • Radiation Oncology - The Department of Radiation Oncology provides advanced treatments such as a TomoTherapy in a safe and compassionate environment and develops new ways to administer radiation more effectively and with fewer side effects.
 

City of Hope embodies the spirit of scientific collaboration by sharing services and core research facilities with colleagues here and around the world. We provide access to specialized equipment, laboratories, scientific expertise and resources such as the Graff Medical and Scientific Library.
 

The Sylvia R. and Isador A. Deutch Center for Applied Technology Development offers broad expertise in technology transfer and licensing, biologics manufacturing, quality assurance and regulatory affairs.
 

City of Hope offers a number of exciting fellowships and residencies in laboratory research, administration, clinical applications and other areas.
 
 

Medical and Research Events Calendar

City of Hope's Medical and Research Calendar is easy to navigate - just move your cursor over or click a date or event description. You can also add the events to your personal calendar, email event information to yourself or others, set up email and cell phone text message reminders on events and other event actions. Additionally, you can subscribe to this calendar in different ways including RSS and Atom Feeds and weekly emails.

 

Latest Research News and Videos

What makes City of Hope research different? Collaboration(w/VIDEO)

What makes City of Hope research different? Collaboration (w/VIDEO)

Regardless of their institution, all cancer researchers want one thing – to find a cure for cancer. But City of Hope researchers have some advantages in this quest. The advantages start with a culture...

May 8, 2014

 
‘Why?’ With cancer, no good answers – but a determination tofind them

‘Why?’ With cancer, no good answers – but a determination to find them

“Why?” The question is a natural one for people diagnosed with cancer. “Why did this cancer develop?” “What caused it?” “How did it start?” The questions send people searching for possible links – to ...

May 5, 2014

 
Meet our doctors: Ravi Bhatia on better survival for leukemiapatients

Meet our doctors: Ravi Bhatia on better survival for leukemia patients

Every four minutes, someone is diagnosed with a blood cancer. More than 156,000 new cases in the U.S. are expected this year alone, with more than 52,000 of those diagnosed as leukemias. Causes of the...

May 3, 2014

 
 
 
 
 

Research Overview

Research Overview

Research pioneered at City of Hope and its renowned Beckman Research Institute has improved the lives of men, women and children throughout the world.
 
Our reputation for scientific excellence – for fundamentally advancing the world’s understanding of cancer, diabetes, HIV/AIDS and other life-threatening diseases – stems from our determination to aggressively pursue lines of inquiry outside traditional paradigms.
 
As an independent biomedical, treatment and education center, we have the infrastructure and collaborative energy to move from bold, innovative concept to powerful new treatment swiftly. 
 
  • We are a national leader in translational research, where ideas continuously flow between investigators and clinicians.
     
  • City of Hope has not one but three on-site manufacturing facilities that enable investigators to manufacture promising new therapies without the high cost and delays encountered by other research centers.
     
  • Many of our clinical research breakthroughs have transformed the landscape of modern medicine. We helped launch the biotech industry with the development of technologies that led to the first synthetic human insulin and human growth hormone.
     
  • Our research also made possible the widely used cancer fighting drugs, Herceptin, Rituxan and Avastin.
     
  • City of Hope has more than 200 patents. At any given time, we have more than 30 investigational new drug applications. These numbers are exceptionally large for an organization of City of Hope’s size, reflecting our commitment to innovation and speeding treatments to patients
     
Discoveries happen at City of Hope because we foster an environment that supports intellectual creativity and freedom – the kind of thinking that enables us to redefine the future of medical research and medicine.


The first of only five Beckman Research Institutes established by funding from the Arnold and Mabel Beckman Foundation, we are responsible for fundamentally expanding the world’s understanding of how biology affects diseases such as cancer, HIV/AIDS and diabetes. Our breakthroughs in the areas of recombinant DNA technology, gene therapy and monoclonal antibodies are testaments to the culture of collaboration that inspires and informs our work.  Departments and divisions include:  Cancer Biology, Cancer Immunotherapeutics & Tumor Immunology, Diabetes and Metabolic Diseases Research (Division of Molecular Diabetes Research and Division of Developmental and Translational Diabetes and Endocrine Research), Immunology, Molecular and Cellular Biology, Molecular Medicine, Molecular Pharmacology, Neurosciences, Population Sciences (Division of Cancer Etiology, Division of Clinical Cancer Genetics, Division of Outcomes Research, Center for Cancer Survivorship, Division of Nursing Research and Education), Radiation Biology, Virology (Translational Vaccine Research).
 

City of Hope is one of only 41 Comprehensive Cancer Centers in the country, the highest designation awarded by the National Cancer Institute to institutions that lead the way in cancer research, treatment, prevention and education. Our five Cancer Center Research Programs run the gamut from basic and translational studies, which begin in our Molecular Oncology (MONC) and Developmental Cancer Therapeutics (DCT) Programs, to Phase I and II clinical protocols in all three clinical programs -  DCT, Cancer Immunotherapeutics (CI), and Hematologic Malignancies (HM) - and follow-up studies in survivorship and symptom management in the Cancer Control and Population Sciences (CCPS).
 
Clinical Research

From clinical trials of drugs and treatments, to studies on cancer survivorship, our multidisciplinary teams of basic, clinical and population science investigators collaborate on improving the lives of patients throughout the world.
 
  • Clinical Trials - Clinical trials, research studies that involve volunteer patients, are a crucial component to developing new, more effective treatments that save lives. Many of today’s standard therapies are based on the results of previous trials, some of which were initiated at City of Hope.
  • Phase I Clinical Trials Program - City of Hope investigates new and experimental cancer medicines, novel treatment combinations and other therapeutic methods through its Phase I Clinical Trials Program. The program offers patients access to some of the most advanced treatments in their earliest stages of development.
  • Diabetes, Endocrinology & Metabolism - From leading collaborative research programs in islet transplantation, engineering and immunology to developing therapies that control complications, this division is recognized nationwide for its innovative approaches to diabetes care.
  • Hematopoietic Stem Cell and Leukemia Research - A pioneer in bone marrow transplantation, this division is part of one of the largest, most successful bone marrow and stem cell transplantation programs of its kind in the world and continues to refine the science of transplantation. The focus of the division is to improve the understanding of leukemia stem cells in order to develop cures for leukemia and other hematologic malignancies.
  • Medical Oncology and Therapeutics Research - The Department of Medical Oncology and Therapeutics Research focuses on the treatment and prevention of solid tumors.
  • Pathology - Recognized worldwide for its diagnostic excellence, the Department of Pathology is led by renowned investigators and equipped with the most advanced technologies available.
  • Radiation Oncology - The Department of Radiation Oncology provides advanced treatments such as a TomoTherapy in a safe and compassionate environment and develops new ways to administer radiation more effectively and with fewer side effects.
 

City of Hope embodies the spirit of scientific collaboration by sharing services and core research facilities with colleagues here and around the world. We provide access to specialized equipment, laboratories, scientific expertise and resources such as the Graff Medical and Scientific Library.
 

The Sylvia R. and Isador A. Deutch Center for Applied Technology Development offers broad expertise in technology transfer and licensing, biologics manufacturing, quality assurance and regulatory affairs.
 

City of Hope offers a number of exciting fellowships and residencies in laboratory research, administration, clinical applications and other areas.
 
 

Medical and Research Events

Medical and Research Events Calendar

City of Hope's Medical and Research Calendar is easy to navigate - just move your cursor over or click a date or event description. You can also add the events to your personal calendar, email event information to yourself or others, set up email and cell phone text message reminders on events and other event actions. Additionally, you can subscribe to this calendar in different ways including RSS and Atom Feeds and weekly emails.

 

Research News and Videos

Latest Research News and Videos

What makes City of Hope research different? Collaboration(w/VIDEO)

What makes City of Hope research different? Collaboration (w/VIDEO)

Regardless of their institution, all cancer researchers want one thing – to find a cure for cancer. But City of Hope researchers have some advantages in this quest. The advantages start with a culture...

May 8, 2014

 
‘Why?’ With cancer, no good answers – but a determination tofind them

‘Why?’ With cancer, no good answers – but a determination to find them

“Why?” The question is a natural one for people diagnosed with cancer. “Why did this cancer develop?” “What caused it?” “How did it start?” The questions send people searching for possible links – to ...

May 5, 2014

 
Meet our doctors: Ravi Bhatia on better survival for leukemiapatients

Meet our doctors: Ravi Bhatia on better survival for leukemia patients

Every four minutes, someone is diagnosed with a blood cancer. More than 156,000 new cases in the U.S. are expected this year alone, with more than 52,000 of those diagnosed as leukemias. Causes of the...

May 3, 2014

 
 
 
 
 
 
Research Videos
Our Scientists

Our research laboratories are led by the best and brightest minds in scientific research.
 

Research Shared Services

City of Hope embodies the spirit of scientific collaboration by sharing services and core facilities with colleagues here and around the world.
 

Technology & Licensing
The Center for Applied Technology Development offers broad expertise in
technology transfer and licensing, biologics manufacturing, quality assurance and regulatory affairs.

City of Hope offers a number of exciting fellowships and residencies in laboratory research, administration, clinical applications and other areas.


NEWS & UPDATES
  • The body’s immune system is usually adept at attacking outside invaders such as bacteria and viruses. But because cancer originates from the body’s own cells, the immune system can fail to see it as foreign. As a result, the body’s most powerful ally can remain largely idle against cancer as the disease progres...
  • On Jan. 1, 2015, five City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the parade is “Inspiring Stories.” Her...
  • Are you thinking about switching from traditional cigarettes to e-cigarettes for the Great American Smokeout? Are you thinking that might be a better option than the traditional quit-smoking route? Think again. For lung expert Brian Tiep, M.D., the dislike and distrust he feels for e-cigs comes down to this: Th...
  • Hematologist Robert Chen, M.D., is boosting scientific discovery at City of Hope and, by extension, across the nation. Just ask the National Cancer Institute. The institution recently awarded Chen the much-sought-after Clinical Investigator Team Leadership Award for boosting scientific discovery at City of Hope...
  • Great strides have been made in treating cancer – including lung cancer – but by the time people show symptoms of the disease, the cancer has usually advanced. That’s because, at early stages, lung cancer has no symptoms. Only recently has lung cancer screening become an option. (Read more about the risks...
  • Identifying cures for currently incurable diseases and providing patients with safe, fast and potentially lifesaving treatments is the focus of City of Hope’s new Alpha Clinic for Cell Therapy and Innovation (ACT-I). The clinic is funded by an $8 million, five-year grant from the California Institute for Regene...
  • Cancer is a couple’s disease. It affects not just the person diagnosed, but his or her partner as well. It also affects the ability of both people to communicate effectively. The Couples Coping with Cancer Together program at City of Hope teaches couples how to communicate and solve problems as a unit. He...
  • Chemotherapy drugs work by either killing cancer cells or by stopping them from multiplying, that is, dividing. Some of the more powerful drugs used to treat cancer do their job by interfering with the cancer cells’ DNA and RNA growth, preventing them from copying themselves and dividing. Such drugs, however, l...
  • During October, everything seems to turn pink – clothing, the NFL logo, tape dispensers, boxing gloves, blenders, soup cans, you name it – in order to raise awareness for what many believe is the most dangerous cancer that affects women: breast cancer. But, in addition to thinking pink, women should...
  • In February 2003, when she was only 16 months old, Maya Gallardo was diagnosed with acute myelogenous leukemia (AML) and, to make matters much worse, pneumonia. The pneumonia complicated what was already destined to be grueling treatment regimen. To assess the extent of her illness, Maya had to endure a spinal ...
  • Former smokers age 55 to 74 who rely on Medicare for health care services have just received a long-hoped-for announcement. Under a proposed decision from the Centers for Medicare and Medicaid Services, they’ll now have access to lung cancer screening with a low-dose CT scan. The proposed decision, announ...
  • City of Hope has a longstanding commitment to combating diabetes, a leading national and global health threat. Already, it’s scored some successes, from research that led to the development of synthetic human insulin – still used by millions of patients – to potentially lifesaving islet cell transplants. Diabet...
  • Dee Hunt never smoked. Neither did her five sisters and brothers. They didn’t have exposure to radon or asbestos, either. That didn’t prevent every one of them from being diagnosed with lung cancer. Their parents were smokers, but they’d all left home more than 30 years before any of them were diagn...
  • They may not talk about it, but women with cancers in the pelvic region, such as cervical cancer, bladder cancer and uterine cancer, often have problems controlling their urine, bowel or flatus. Although they may feel isolated, they’re far from alone. Many other women have such problems, too. In fact, nea...
  • Cancer that spreads to the liver poses a significant threat to patients, and a great challenge to surgeons. The organ’s anatomical complexity and its maze of blood vessels make removal of tumors difficult, even for specialized liver cancer surgeons. Following chemotherapy, the livers of cancer patients are not ...