A National Cancer Institute-designated Comprehensive Cancer Center

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Comprehensive Cancer Center

City of Hope has a proud history of excellence in biomedical research, patient-centered medical care, and community outreach.
 
In recognition of our broad-based innovations in cancer research and treatment, our continuing commitment to compassionate patient care, and our initiatives in patient and community education, the National Cancer Institute (NCI) has designated City of Hope a Comprehensive Cancer Center — the highest level of recognition bestowed by the NCI. City of Hope is one of just a handful of elite institutions nationwide to receive this prestigious honor.
 
As a division of the National Institutes of Health, the NCI is the Federal Government's principal agency for cancer research and training. The NCI's Cancer Center program acknowledges institutions for their scientific excellence, as well as their ability to bring diverse research approaches to the problem of cancer. The "Comprehensive Cancer Center" designation indicates that City of Hope has undergone a rigorous review process and has met or exceeded NCI standards in these areas.
 

City of Hope Comprehensive Cancer Center researchers and resources are dedicated to developing innovative new disease-fighting strategies in the battle against cancer. Through these programs, and through the mission and vision of City of Hope physicians and scientists, City of Hope Comprehensive Cancer Center will continue to make a difference in the lives of current and potential cancer patients and their loved ones—around the world today and in the future.
 
 
All of these activities are made possible by a forward-thinking infrastructure supporting basic and translational research in biological and small molecule cancer therapeutics.
 

Cancer Center Leadership

Cancer Center Program Co-leaders

About Our Cancer Center Research Programs

City of Hope provides a multidisciplinary, interactive environment where basic, clinical and translational, and prevention and control scientists collaborate closely. This stimulating intellectual environment contributes to the productive translational research under way within the Comprehensive Cancer Center. Our research initiatives are divided into the following research programs:
 
Basic Science Research Program

The Comprehensive Cancer Center provides both the infrastructure and the environment for outstanding basic science research. ("Basic science" refers to research conducted in a laboratory setting.) In turn, this research contributes to our understanding of the underlying genetic, molecular and biological bases of cancer. The basic science research program at City of Hope is called Molecular Oncology (MONC).
 
Clinical and Translational Research Programs

The Comprehensive Cancer Center's clinical and translational research programs focus on the translation of novel laboratory observations into the treatment of patients (and their families) and, ultimately, throughout the world. The number of the Center's novel (Phases I and I/II) clinical trials increases yearly. The clinical and translational science research programs are:
 
 
Prevention and Control Program
 
Cancer prevention and control research at the Comprehensive Cancer Center is conducted within a program on Cancer Control and Population Sciences (CCPS). The members of this research program cover an extensive spectrum of disciplines, which is further broadened by additional collaborations with physician investigators. Such a confederation of expertise, working within a collaborative environment, maximizes productive interaction. The program focuses on four important areas of concentration:
 
  • Host and environmental determinants of cancer
  • Health-related outcomes and quality of life after cancer
  • Interventional studies to reduce cancer-related morbidity
  • Educational initiatives
 
Our five research programs, described above, represent a continuum, as shown in the figure below. Basic and translational studies can originate in either the basic science program,MO or the DCT Program. These studies can then link to phase I and II clinical protocols in all three clinical programs—DCT, CI and HM. They can also integrate into follow-up studies in survivorship and symptom management in the CCPS Program. On this continuum, CI spans both translational and clinical research, whereas HM is predominantly (but not exclusively) clinical. Frequent interaction between the principal investigators of each program ensures maximum benefit from shared insights. All these activities are made possible by City of Hope’s infrastructure, which supports basic and translational research in biological and in small molecule approaches to cancer.

The arrow in the figure below represents our realization that, even as activities move to the right toward clinical realization, there is a strong requirement to recycle back to developmental activities in response to the knowledge we gain in early clinical application. Our scientists are already doing this routinely, aided by our flexible and responsive infrastructure. The CCPS Program also contributes to the cycle by providing downstream information on effects of therapy and also potential prevention and therapeutic targets — findings arising out of survivorship and molecular epidemiological work of CCPS. These findings may then be explored by other programs in the continuum.
 
 
 

Community Outreach

As a Comprehensive Cancer Center, City of Hope plays an important role in the community. We continually use the knowledge gained from our ongoing research to influence the standards of prevention and care, and to educate physicians, caregivers, and patients alike.
 
 

Why Choose a Comprehensive Cancer Center?

Only a National Cancer Institute (NCI)-designated Comprehensive Cancer Center such as City of Hope offers a full complement of services designed to address all aspects of cancer, from understanding its origins, to developing new therapies and testing them in patient clinical trials, to delivering superior patient care and providing support and education to patients, their families and the public.
 
City of Hope is one of a select few cancer centers nationwide to have received this prestigious honor. NCI-funded cancer centers must go through a rigorous review process every five years, in which they are evaluated and ranked. Only those conducting the most promising cancer research are awarded Comprehensive Cancer Center status. It is an important credential to consider when choosing a cancer treatment facility.
 
As a patient, a diagnosis of cancer brings with it many questions and concerns. Choosing a Comprehensive Cancer Center such as City of Hope is an empowering step, equipping you with the best possible resources to fight the disease.
 
Attributes of a Comprehensive Cancer Center
To achieve the Comprehensive Cancer Center designation, organizations must support a broad range of research programs and approach the problem of cancer in many different ways. Comprehensive Cancer Centers like City of Hope must have strong programs in all of the following areas:
 
Comprehensive Cancer Centers also play important roles in their communities and regions, and influence the standards of prevention and care.
 
National Comprehensive Cancer Network Founding Member
Of the relatively few NCI-designated Comprehensive Cancer Centers, only an elite 21 comprise the National Comprehensive Cancer Network ( NCCN ), an alliance of the nation's leading Comprehensive Cancer Centers that defines and sets standards for cancer care. City of Hope is proud to be a founding member of the NCCN. NCCN member institutions are recognized for their world-renowned experts and for dealing with particularly complex, rare and aggressive forms of cancer. As an NCCN member institution, City of Hope plays a critical role in advancing state-of-the-art cancer treatment through education, research, and patient care. Learn more about the NCCN at www.nccn.org.
 

Comprehensive Cancer Center

Comprehensive Cancer Center

City of Hope has a proud history of excellence in biomedical research, patient-centered medical care, and community outreach.
 
In recognition of our broad-based innovations in cancer research and treatment, our continuing commitment to compassionate patient care, and our initiatives in patient and community education, the National Cancer Institute (NCI) has designated City of Hope a Comprehensive Cancer Center — the highest level of recognition bestowed by the NCI. City of Hope is one of just a handful of elite institutions nationwide to receive this prestigious honor.
 
As a division of the National Institutes of Health, the NCI is the Federal Government's principal agency for cancer research and training. The NCI's Cancer Center program acknowledges institutions for their scientific excellence, as well as their ability to bring diverse research approaches to the problem of cancer. The "Comprehensive Cancer Center" designation indicates that City of Hope has undergone a rigorous review process and has met or exceeded NCI standards in these areas.
 

City of Hope Comprehensive Cancer Center researchers and resources are dedicated to developing innovative new disease-fighting strategies in the battle against cancer. Through these programs, and through the mission and vision of City of Hope physicians and scientists, City of Hope Comprehensive Cancer Center will continue to make a difference in the lives of current and potential cancer patients and their loved ones—around the world today and in the future.
 
 
All of these activities are made possible by a forward-thinking infrastructure supporting basic and translational research in biological and small molecule cancer therapeutics.
 

Cancer Center Leadership

Cancer Center Leadership

Cancer Center Program Co-leaders

Cancer Center Program Co-leaders

Cancer Center Research Programs

About Our Cancer Center Research Programs

City of Hope provides a multidisciplinary, interactive environment where basic, clinical and translational, and prevention and control scientists collaborate closely. This stimulating intellectual environment contributes to the productive translational research under way within the Comprehensive Cancer Center. Our research initiatives are divided into the following research programs:
 
Basic Science Research Program

The Comprehensive Cancer Center provides both the infrastructure and the environment for outstanding basic science research. ("Basic science" refers to research conducted in a laboratory setting.) In turn, this research contributes to our understanding of the underlying genetic, molecular and biological bases of cancer. The basic science research program at City of Hope is called Molecular Oncology (MONC).
 
Clinical and Translational Research Programs

The Comprehensive Cancer Center's clinical and translational research programs focus on the translation of novel laboratory observations into the treatment of patients (and their families) and, ultimately, throughout the world. The number of the Center's novel (Phases I and I/II) clinical trials increases yearly. The clinical and translational science research programs are:
 
 
Prevention and Control Program
 
Cancer prevention and control research at the Comprehensive Cancer Center is conducted within a program on Cancer Control and Population Sciences (CCPS). The members of this research program cover an extensive spectrum of disciplines, which is further broadened by additional collaborations with physician investigators. Such a confederation of expertise, working within a collaborative environment, maximizes productive interaction. The program focuses on four important areas of concentration:
 
  • Host and environmental determinants of cancer
  • Health-related outcomes and quality of life after cancer
  • Interventional studies to reduce cancer-related morbidity
  • Educational initiatives
 
Our five research programs, described above, represent a continuum, as shown in the figure below. Basic and translational studies can originate in either the basic science program,MO or the DCT Program. These studies can then link to phase I and II clinical protocols in all three clinical programs—DCT, CI and HM. They can also integrate into follow-up studies in survivorship and symptom management in the CCPS Program. On this continuum, CI spans both translational and clinical research, whereas HM is predominantly (but not exclusively) clinical. Frequent interaction between the principal investigators of each program ensures maximum benefit from shared insights. All these activities are made possible by City of Hope’s infrastructure, which supports basic and translational research in biological and in small molecule approaches to cancer.

The arrow in the figure below represents our realization that, even as activities move to the right toward clinical realization, there is a strong requirement to recycle back to developmental activities in response to the knowledge we gain in early clinical application. Our scientists are already doing this routinely, aided by our flexible and responsive infrastructure. The CCPS Program also contributes to the cycle by providing downstream information on effects of therapy and also potential prevention and therapeutic targets — findings arising out of survivorship and molecular epidemiological work of CCPS. These findings may then be explored by other programs in the continuum.
 
 
 

Community Outreach

Community Outreach

As a Comprehensive Cancer Center, City of Hope plays an important role in the community. We continually use the knowledge gained from our ongoing research to influence the standards of prevention and care, and to educate physicians, caregivers, and patients alike.
 
 

Why Choose A Comprehensive Cancer Center?

Why Choose a Comprehensive Cancer Center?

Only a National Cancer Institute (NCI)-designated Comprehensive Cancer Center such as City of Hope offers a full complement of services designed to address all aspects of cancer, from understanding its origins, to developing new therapies and testing them in patient clinical trials, to delivering superior patient care and providing support and education to patients, their families and the public.
 
City of Hope is one of a select few cancer centers nationwide to have received this prestigious honor. NCI-funded cancer centers must go through a rigorous review process every five years, in which they are evaluated and ranked. Only those conducting the most promising cancer research are awarded Comprehensive Cancer Center status. It is an important credential to consider when choosing a cancer treatment facility.
 
As a patient, a diagnosis of cancer brings with it many questions and concerns. Choosing a Comprehensive Cancer Center such as City of Hope is an empowering step, equipping you with the best possible resources to fight the disease.
 
Attributes of a Comprehensive Cancer Center
To achieve the Comprehensive Cancer Center designation, organizations must support a broad range of research programs and approach the problem of cancer in many different ways. Comprehensive Cancer Centers like City of Hope must have strong programs in all of the following areas:
 
Comprehensive Cancer Centers also play important roles in their communities and regions, and influence the standards of prevention and care.
 
National Comprehensive Cancer Network Founding Member
Of the relatively few NCI-designated Comprehensive Cancer Centers, only an elite 21 comprise the National Comprehensive Cancer Network ( NCCN ), an alliance of the nation's leading Comprehensive Cancer Centers that defines and sets standards for cancer care. City of Hope is proud to be a founding member of the NCCN. NCCN member institutions are recognized for their world-renowned experts and for dealing with particularly complex, rare and aggressive forms of cancer. As an NCCN member institution, City of Hope plays a critical role in advancing state-of-the-art cancer treatment through education, research, and patient care. Learn more about the NCCN at www.nccn.org.
 
Research Shared Services

City of Hope embodies the spirit of scientific collaboration by sharing services and core facilities with colleagues here and around the world.
 

Clinical Trials
Our aggressive pursuit to discover better ways to help patients now – not years from now – places us among the leaders worldwide in the administration of clinical trials.
 
Learn more about City of Hope's institutional distinctions, breakthrough innovations and collaborations.
Discover the wide range of progressive cancer treatment options at City of Hope designed to meet the individual needs of each patient. Here, medical research and clinical care are integrated, speeding the application of scientific discoveries toward better, more effective patient cancer treatments.
City of Hope Breakthroughs
Get the latest in City of Hope's research, treatment and news you can use on our blog, Breakthroughs.
 
 
When you support City of Hope, you help us shorten the time it takes to get from bold, innovative ideas to powerful new medical treatments. Make a gift online now.


NEWS & UPDATES
  • It was 2009 when a City of Hope patient in her 40s learned that the cancer she had been fighting for several years had metastasized to her lungs. Her medical team ran genetic tests on the tumor, but none of the drug therapies available at the time targeted the known mutations in the tumor cells. […]
  • Acute myeloid leukemia (AML) is characterized by a rapidly-developing cancer in the myeloid line of blood cells, which is responsible for producing red blood cells, platelets and several types of white blood cells called granulocytes. Because AML grows rapidly, it can quickly crowd out normal blood cells, leadi...
  • Rachel Divine is a yoga therapist and patient leader for the Sheri & Les Biller Patient and Family Resource Center. She’s also a former City of Hope patient. When someone you know has cancer, even the word “cancer” can make you feel nervous, sleepless, depressed or more. But, as a yoga teacher for 15 ...
  •   Diagnosed with type 1 diabetes when she was 9 years old, Gina Marchini accepted the fact that she would need insulin the rest of her life. Every day, she injected herself with the lifesaving hormone. She also carefully controlled her diet and monitored the rise and fall of her blood glucose with military...
  • The defeat of cancer will require a team effort. Nowhere is this more necessary (or apparent) than in efforts to combat two of the most deadly forms of the disease  – pancreatic cancer and triple-negative breast cancer. It’s the approach City of Hope is taking with its newly launched multidisciplinary teams, br...
  • It’s a reasonable question: Why is the National Cancer Institute funding a study on preventing heart failure? The answer is reasonable as well: Rates of heart failure are drastically high among childhood cancer survivors — 15 times higher than among people the same age who were never treated for cancer. T...
  • Many teenagers take a break from academics during the summer, but not the eight high school students enrolled in the California Institute for Regenerative Medicine (CIRM) Creativity Awards program at City of Hope. They took the opportunity to obtain as much hands-on research experience as possible, learning fro...
  • About one in eight women will develop breast cancer at some point in her life. In fact, breast cancer is the most common cancer in American women, behind skin cancer. Although women can’t change some risk factors, such as genetics and the natural aging process, there are certain things they can do to lower thei...
  • As genetic testing becomes more sophisticated, doctors and their patients are finding that such tests can lead to the discovery of previously unknown cancer risks. In his practice at City of Hope, Thomas Slavin, M.D., an assistant clinical professor in the Division of Clinical Cancer Genetics, sees the full spe...
  • And the winners are … everyone in the San Gabriel Valley. The recipients of City of Hope’s first-ever Healthy Living grants have been announced, and the future is looking healthier already. In selecting San Gabriel Valley organizations to receive the grants, City of Hope’s Community Benefits Advisory Council ch...
  • Barry Leshowitz is a former City of Hope patient and a family advisor for the Sheri & Les Biller Patient and Family Resource Center. It’s been almost seven years since I checked into a local hospital in Phoenix for a hip replacement, only to be informed by the surgeon that he had canceled the surgery....
  • When it comes to science, the best graduate schools don’t just train scientists, they prepare their students for a lifetime of learning, accomplishment and positive impact on society. At City of Hope, the Irell & Manella Graduate School of Biological Sciences goes one step further – by preparing students to...
  • Cancer affects not just the cancer patient, but everyone around him or her, even after treatment is complete. The challenges can include the fear of cancer recurrence, coping with cancer’s economic impact and the struggle to achieve work-life balance post-treatment. Family members and loved ones of cancer patie...
  •   Bladder cancer facts: Bladder cancer is a disease in which malignant (cancer) cells form in the tissues of the bladder. 2015 estimates: 74,000 new cases of bladder cancer diagnosed 16,000 deaths from bladder cancer (about 11,510 in men and 4,490 in women) Risk factors for bladder cancer: Smoking: Smokers...
  • Women with ovarian cancer have questions about the most promising treatment options, revolutionary research avenues, survivorship and, of course, the potential impact on their personal lives. Now, together in one place, are experts who can provide answers. On Saturday, Sept. 12, the 2015 Ovarian Cancer Survivor...