A National Cancer Institute-designated Comprehensive Cancer Center

Make an appointment: 800-826-HOPE
Radiation Biology Bookmark and Share

Department of Radiation Biology

The Department of Radiation Biology was established to study the fundamental mechanisms of DNA replication and DNA damage repair during cell growth. Efficient DNA damage repair is important for maintaining genome integrity and preventing cancer development in normal cells, but it is also a leading cause for radiation resistance in cancer cells. The department currently has three research groups working under its chair, Binghui Shen, Ph.D to define different aspects of genome maintenance that contribute to tumor etiology and to find a solution for radiation resistance by modulating DNA damage repair pathways in cancer therapy. These groups share a common interest in radiation-induced DNA damage and repair and radiation resistance. The principal investigators and their associates will direct efforts in radiation research toward fulfilling departmental goals, and working in close collaboration with radiation oncologists and other scientists at City of Hope.
 

Binghui Shen, Ph.D. - Enzymology of DNA Replication and Repair and Mouse Models of Cancer
Dr. Shen studies enzymes and mechanisms involved in the replication and repair of DNA damage caused by radiation and other environmental insults employing genetic mouse models of cancer. 


Jeremy Stark, Ph.D. - The Regulation and Fidelity of Chromosomal Break Repair Pathways
The long-term goal of Dr. Stark’s laboratory is to understand the factors and conditions that affect the regulation and fidelity of chromosomal break repair in mammalian cells.

Yilun Liu, Ph.D. - Genome Instability and Human Diseases

Dr. Liu’s long-term agenda is to understand what aspects of genome maintenance and DNA metabolism are required for normal development and cancer prevention.
 
Yanzhong Yang, M.D., Ph.D. - Mechanisms of Gene Regulation and Genome Stability
 
The research in Dr. Yang’s laboratory focuses on studying the molecular mechanisms that regulate gene expression and genome stability, as well as their implications for human diseases.

Radiation Biology

Department of Radiation Biology

The Department of Radiation Biology was established to study the fundamental mechanisms of DNA replication and DNA damage repair during cell growth. Efficient DNA damage repair is important for maintaining genome integrity and preventing cancer development in normal cells, but it is also a leading cause for radiation resistance in cancer cells. The department currently has three research groups working under its chair, Binghui Shen, Ph.D to define different aspects of genome maintenance that contribute to tumor etiology and to find a solution for radiation resistance by modulating DNA damage repair pathways in cancer therapy. These groups share a common interest in radiation-induced DNA damage and repair and radiation resistance. The principal investigators and their associates will direct efforts in radiation research toward fulfilling departmental goals, and working in close collaboration with radiation oncologists and other scientists at City of Hope.
 

Binghui Shen, Ph.D. - Enzymology of DNA Replication and Repair and Mouse Models of Cancer
Dr. Shen studies enzymes and mechanisms involved in the replication and repair of DNA damage caused by radiation and other environmental insults employing genetic mouse models of cancer. 


Jeremy Stark, Ph.D. - The Regulation and Fidelity of Chromosomal Break Repair Pathways
The long-term goal of Dr. Stark’s laboratory is to understand the factors and conditions that affect the regulation and fidelity of chromosomal break repair in mammalian cells.

Yilun Liu, Ph.D. - Genome Instability and Human Diseases

Dr. Liu’s long-term agenda is to understand what aspects of genome maintenance and DNA metabolism are required for normal development and cancer prevention.
 
Yanzhong Yang, M.D., Ph.D. - Mechanisms of Gene Regulation and Genome Stability
 
The research in Dr. Yang’s laboratory focuses on studying the molecular mechanisms that regulate gene expression and genome stability, as well as their implications for human diseases.
Overview
Beckman Research Institute of City of Hope is responsible for fundamentally expanding the world’s understanding of how biology affects diseases such as cancer, HIV/AIDS and diabetes.
 
 
Research Departments/Divisions

City of Hope is a leader in translational research - integrating basic science, clinical research and patient care.
 

Research Shared Services

City of Hope embodies the spirit of scientific collaboration by sharing services and core facilities with colleagues here and around the world.
 

Our Scientists

Our research laboratories are led by the best and brightest minds in scientific research.
 

City of Hope’s Irell & Manella Graduate School of Biological Sciences equips students with the skills and strategies to transform the future of modern medicine.
Develop new therapies, diagnostics and preventions in the fight against cancer and other life-threatening diseases.
 


NEWS & UPDATES
  • Eight years ago, Matthew Loscalzo surprised himself by accepting the offer to become City of Hope’s administrative director of the Sheri & Les Biller Patient and Family Resource Center and executive director of the Department of Supportive Care Medicine. At the time, he was administrative director of the Sc...
  • The mental fog that patients can experience after undergoing chemotherapy treatment for cancer has a name: “chemo brain.” “Many patients report hearing or reading about chemotherapy-related cognitive deficits, but few are actually prepared to deal with these changes,” said Celina Lemon, M.A., an occupational th...
  • Cancer treatments have improved over the years, but one potential source of treatments and cures remains largely untapped: nature. Blueberries, cinnamon, xinfeng, grape seed (and skin) extract, mushrooms, barberry and pomegranates all contain compounds with the potential to treat or prevent cancer. Scientists a...
  • In the U.S., there are more new cases of skin cancer than the combined incidence of cancers of the breast, prostate and lung, according to the American Cancer Society. Each year, 5 million people are treated for skin cancer. Here, Hans Schoellhammer, M.D., assistant clinical professor at City of Hope | Ant...
  • As public health experts know, health improvement starts in the community. Now, City of Hope  has been recognized for its efforts to improve the lives of residents of its own community. The institution will receive funding from the Institute for Healthcare Improvement  to support promising community-based work ...
  • For almost four decades, blood cancer survivors who received bone marrow, or stem cell, transplants have returned to City of Hope to celebrate life, second chances and science. The first reunion, in 1976, was a small affair: spaghetti for a single patient, his brother who served as his donor and those who took ...
  • Chemotherapy is an often-essential component of cancer treatment, attacking cells that divide quickly and helping stop cancer’s advance. But the very characteristics that make chemotherapy effective against cancer also can make it toxic to healthy cells, leading to side effects such as hair loss, nausea, ...
  • When you want to understand how to enhance the patient experience, go straight to the source: The patients. Patients and their families offer unique perspectives on care and services and can provide valuable insights about what is working well and what is not. That’s why City of Hope turns to them for advice. S...
  • Take it from City of Hope researchers: Medical science isn’t just for scientists, but something the whole family can enjoy. From 1 to 4 p.m. on Saturday, May 16, the institution will offer a variety of educational and fun-filled science and healthy living activities at its second Community Science Festiva...
  • Attention, parents! Only a few serious sunburns can increase a child’s ultimate risk of skin cancer. Further, some studies suggest that ultraviolet (UV) exposure before the age of 10 is the most important factor for melanoma risk. Here skin cancer expert Jae Jung, M.D., Ph.D., assistant professor in the D...
  • Esophagheal cancer may not be on many people’s radar, but heartburn probably is. The latter can ultimately lead to the former. More formally referred to as gastroesophageal reflux, heartburn occurs when stomach content makes its way back up into the esophagus, causing stomach acid to come into contact with the ...
  • Many City of Hope cancer patients are opening their hearts to an electronic confidante. The tablet-based program, called SupportScreen, prompts them to share deeply personal concerns about their health — and helps jump-start their care. “We’ve found that people will reveal more to a machine than to a person. Te...
  • Older adults, by far, represent the largest population of cancer patients globally. With the median age of U.S. citizens projected to increase sharply in the next few years, the incidence of cancer is expected to rise higher, as well. City of Hope is at the forefront of geriatric cancer care, and an important n...
  • Treatment of cancers of the head and neck requires not just skill, but consummate skill. After all, consider their location: the lip, mouth, tongue, throat and nasal cavity – and that’s just for starters. Such treatment can include chemotherapy and radiation, but surgery is often the primary approach, wit...
  • On a spring day in 2013, 10-year-old Jackie Garcia of Whittier, California, noticed a lump in her jaw. Her mother suspected it was a minor problem, perhaps due to a fall, but made an appointment with a pediatrician, just to be on the safe side. “He thought it was an infection that was dental-related, and told [...