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Department of Radiation Biology

The Department of Radiation Biology was established to study the fundamental mechanisms of DNA replication and DNA damage repair during cell growth. Efficient DNA damage repair is important for maintaining genome integrity and preventing cancer development in normal cells, but it is also a leading cause for radiation resistance in cancer cells. The department currently has three research groups working under its chair, Binghui Shen, Ph.D to define different aspects of genome maintenance that contribute to tumor etiology and to find a solution for radiation resistance by modulating DNA damage repair pathways in cancer therapy. These groups share a common interest in radiation-induced DNA damage and repair and radiation resistance. The principal investigators and their associates will direct efforts in radiation research toward fulfilling departmental goals, and working in close collaboration with radiation oncologists and other scientists at City of Hope.
 

Binghui Shen, Ph.D. - Enzymology of DNA Replication and Repair and Mouse Models of Cancer
Dr. Shen studies enzymes and mechanisms involved in the replication and repair of DNA damage caused by radiation and other environmental insults employing genetic mouse models of cancer. 


Jeremy Stark, Ph.D. - The Regulation and Fidelity of Chromosomal Break Repair Pathways
The long-term goal of Dr. Stark’s laboratory is to understand the factors and conditions that affect the regulation and fidelity of chromosomal break repair in mammalian cells.

Yilun Liu, Ph.D. - Genome Instability and Human Diseases

Dr. Liu’s long-term agenda is to understand what aspects of genome maintenance and DNA metabolism are required for normal development and cancer prevention.
 
Yanzhong Yang, M.D., Ph.D. - Mechanisms of Gene Regulation and Genome Stability
 
The research in Dr. Yang’s laboratory focuses on studying the molecular mechanisms that regulate gene expression and genome stability, as well as their implications for human diseases.

Radiation Biology

Department of Radiation Biology

The Department of Radiation Biology was established to study the fundamental mechanisms of DNA replication and DNA damage repair during cell growth. Efficient DNA damage repair is important for maintaining genome integrity and preventing cancer development in normal cells, but it is also a leading cause for radiation resistance in cancer cells. The department currently has three research groups working under its chair, Binghui Shen, Ph.D to define different aspects of genome maintenance that contribute to tumor etiology and to find a solution for radiation resistance by modulating DNA damage repair pathways in cancer therapy. These groups share a common interest in radiation-induced DNA damage and repair and radiation resistance. The principal investigators and their associates will direct efforts in radiation research toward fulfilling departmental goals, and working in close collaboration with radiation oncologists and other scientists at City of Hope.
 

Binghui Shen, Ph.D. - Enzymology of DNA Replication and Repair and Mouse Models of Cancer
Dr. Shen studies enzymes and mechanisms involved in the replication and repair of DNA damage caused by radiation and other environmental insults employing genetic mouse models of cancer. 


Jeremy Stark, Ph.D. - The Regulation and Fidelity of Chromosomal Break Repair Pathways
The long-term goal of Dr. Stark’s laboratory is to understand the factors and conditions that affect the regulation and fidelity of chromosomal break repair in mammalian cells.

Yilun Liu, Ph.D. - Genome Instability and Human Diseases

Dr. Liu’s long-term agenda is to understand what aspects of genome maintenance and DNA metabolism are required for normal development and cancer prevention.
 
Yanzhong Yang, M.D., Ph.D. - Mechanisms of Gene Regulation and Genome Stability
 
The research in Dr. Yang’s laboratory focuses on studying the molecular mechanisms that regulate gene expression and genome stability, as well as their implications for human diseases.
Overview
Beckman Research Institute of City of Hope is responsible for fundamentally expanding the world’s understanding of how biology affects diseases such as cancer, HIV/AIDS and diabetes.
 
 
Research Departments/Divisions

City of Hope is a leader in translational research - integrating basic science, clinical research and patient care.
 

Research Shared Services

City of Hope embodies the spirit of scientific collaboration by sharing services and core facilities with colleagues here and around the world.
 

Our Scientists

Our research laboratories are led by the best and brightest minds in scientific research.
 

City of Hope’s Irell & Manella Graduate School of Biological Sciences equips students with the skills and strategies to transform the future of modern medicine.
Develop new therapies, diagnostics and preventions in the fight against cancer and other life-threatening diseases.
 


NEWS & UPDATES
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  • Don’t kid yourself. Just because it’s mid-January doesn’t mean it’s too late to make resolutions for a happier, and healthier, 2015. Just consider them resolutions that are more mature than those giddy, sometimes self-deluded, Jan. 1 resolutions. To that end, we share some advice from Cary A. Presant, M.D., an ...
  • Sales and marketing executive Jim Murphy first came to City of Hope in 2002 to donate blood for a friend who was being treated for esophageal cancer. The disease is serious. Although esophageal cancer accounts for only about 1 percent of cancer diagnoses in the U.S., only about 20 percent of patients survive at...
  • Aaron Bomar and his family were celebrating his daughter’s 33rd birthday in September 2014 when he received alarming news: According to an X-ray taken earlier that day at an urgent care facility, he had a node on his aorta and was in danger of an aneurysm. Bomar held hands with his wife and daughter and s...
  • Explaining a prostate cancer diagnosis to a young child can be difficult — especially when the cancer is incurable. But conveying the need for prostate cancer research, as it turns out, is easily done. And that leads to action. Earlier this year, Gerald Rustad, 71, who is living with a very aggressive form of m...