Department of Radiation Biology
The Department of Radiation Biology was established to study the fundamental mechanisms of DNA replication and DNA damage repair during cell growth. Efficient DNA damage repair is important for maintaining genome integrity and preventing cancer development in normal cells, but it is also a leading cause for radiation resistance in cancer cells. The department currently has three research groups working under its chair, Binghui Shen, Ph.D to define different aspects of genome maintenance that contribute to tumor etiology and to find a solution for radiation resistance by modulating DNA damage repair pathways in cancer therapy. These groups share a common interest in radiation-induced DNA damage and repair and radiation resistance. The principal investigators and their associates will direct efforts in radiation research toward fulfilling departmental goals, and working in close collaboration with radiation oncologists and other scientists at City of Hope.
 

Binghui Shen, Ph.D. – Enzymology of DNA Replication and Repair and Mouse Models of Cancer
Dr. Shen studies enzymes and mechanisms involved in the replication and repair of DNA damage caused by radiation and other environmental insults employing genetic mouse models of cancer. 


Jeremy Stark, Ph.D The Regulation and Fidelity of Chromosomal Break Repair Pathways
The long-term goal of Dr. Stark’s laboratory is to understand the factors and conditions that affect the regulation and fidelity of chromosomal break repair in mammalian cells.

Yilun Liu, Ph.D. – Genome Instability and Human Diseases

Dr. Liu’s long-term agenda is to understand what aspects of genome maintenance and DNA metabolism are required for normal development and cancer prevention.