Contact Information
John A. Zaia, M.D.
  • Aaron D. Miller and Edith Miller Chair in Gene Therapy
  • Chair and Professor, Virology
  • Institutional Official for Research
  • Professor of Pediatrics

Departments/Division/Program

Research Areas
  • CMV Immunology
  • HIV-I Gene Therapy

Professional Experience

  • 2009 - present, Institutional Official for Research, City of Hope, Duarte, CA
  • 1999 - present, Chair, Department of Virology, Beckman Research Institute of City of Hope, Duarte, CA
  • 1998 - present, Director, City of Hope General Clinical Research Center Satellite of USC School of Medicine (GCRC), Los Angeles, CA
  • 1980 - present, Director of Virology and Infectious Diseases, Department of Pediatrics, City of Hope
  • 1976 - 1980, Instructor in Medicine, Harvard Medical School; Clinical Associate, Dana Farber Cancer Institute, Boston, MA
  • 1974 - 1977, Fellow in Infectious Diseases, Beth Israel Hospital and Children’s Hospital Medical Center, Boston, MA; Fellow in Infectious Diseases, Dana Farber Cancer Institute, Boston, MA
  • 1971 - 1974, Senior Assistant Surgeon, United States Public Health Service, Virology Division, Laboratory Bureau, Center for Disease Control, Atlanta, GA
  • 1968 - 1971, Intern/Resident, St. Louis Children’s Hospital, St. Louis, Missouri and Children’s Hospital Medical Center, Boston, MA

Education

Education/Training
  • 1968, Harvard University, Boston, MA, M.D., Medicine
  • 1966, Dartmouth College, Hanover, NH, B.M.Sc., Medicine
  • 1964, Holy Cross College, Worchester, MA, A.B., Biology
 

Honors/Awards

Honors
  • 2010-2011, Chairman, NIH Recombinant DNA Advisory Committee
Awards
  • 2008, Aaron D. and Edith Miller Chair in Gene Therapy, Beckman Research Institute of City of Hope
  • 1977, Young Investigator Award, National Institute of Allergy and Infectious Diseases
 

Clinical Trials

  • Clinical Trials

Patents

  • Zaia JA,  Protein kinase deficient, immunologically active CMVpp65 Mutants.  U.S. Patent 7,387,782, June 17, 2008.
  • Zaia JA, Hawkins, G.  Protein Kinase Deficient, Immunologically Active CMVpp65 Mutants.  U.S. Patent 7,025,969 April 11, 2006.
  • Zaia JA, Hawkins, G.  Protein Kinase Deficient, Immunologically Active CMVpp65 Mutants.  U.S. Patent 6,835,383 December 28, 2004.
  • Zaia JA, Giugni, TD, Moller E, Soderberg C.  Treatment of cytomegalovirus using aminopeptidase N.  U.S. Patent 6,511,662 January 28, 2003.
  • Pande H, Riggs A, Zaia JA, Clark B.  Method for Detection and Prevention of Human Cytomegalovirus Infection.  U.S. Patent 6,242,567 June 5, 2001.
  • Pande H, Zaia JA.  Induction of Cytolytic T-Lymphocytes with Cytomegalovirus Polypeptides.  U.S. Patent 6,207,161 March 27, 2001.
  • Pande H, Riggs A, Zaia JA, Clark B.  Method for Detection and Prevention of Human Cytomegalovirus Infection.  U.S. Patent 6,133,433 October17, 2000.
  • Rossi JJ, Cantin EM, Zaia JA, Chang P.  Ribozyme Cleavage of HIV-RNA.  U.S. Patent 6,069,007, May 30, 2000.
  • Rossi JJ, Cantin EM, Zaia JA, Chang P.  Ribozyme Cleavage of HIV-I-RNA.  U.S. Patent 5,144,019, September 1, 1992.
  • Cantin EM, Zaia JA, Wallace RB, Rossi JJ.  Oligonucleotide phosphonates and method of inhibiting a human immunodeficiency virus in vitro utilizing said oligonucleotide phosphonates.  U.S. Patent 5,110,802, May 5, 1992.
  • Pande H, Riggs AD, Zaia JA.  Method for detection and prevention of human cytomegalovirus infection.  U.S. Patent 5,075,213, December 24, 1991.

Publications

Selected Publications
 
  • Stan R, Zaia JA. Practical considerations in gene therapy for HIV cure. Curr HIV/AIDS Rep. 2014 Mar;11(1):11-9. PMID: 24449226 PMCID: 3929767
  • DiGiusto DL, Stan R, Krishnan A, Li H, Rossi JJ, Zaia JA. Development of hematopoietic stem cell based gene therapy for HIV-1 infection: considerations for proof of concept studies and translation to standard medical practice. Viruses. 2013 Nov;5(11):2898-919. PMID: 24284880 PMCID: 3856421
  • Li L, Krymskaya L, Wang J, et al. Genomic editing of the HIV-1 coreceptor CCR5 in adult hematopoietic stem and progenitor cells using zinc finger nucleases. Mol Ther 2013;21:1259-69. PMID:23587921 PMCID:PMC3677314
  • Behrendt CE, Nakamura R, Forman SJ, Zaia JA. Donor killer immunoglobulin-like receptor genes and reactivation of cytomegalovirus after HLA-matched hematopoietic stem-cell transplantation: HLA-C allotype is an essential cofactor. Frontiers in Immunology. 2013;4. PMID:23440333 PMCID:PMC3578282
  • Petz, L.D., Redei, I., Bryson, Y., Regan, D., Kurtzberg, J., Shpall, E., Gutman, J., Querol, S., Clark, P., Tonai, R., Santos, S., Bravo, A., Spellman, S., Gragert, L., Rossi, J., Li, S., Li, H., Senitzer, D., Zaia, J., Rosenthal, J., Forman, S., and Chow, R. Hematopoietic Cell Transplantation with Cord Blood for Cure of HIV Infections. Biology of Blood and Marrow Transplantation, 2013:9, 393-397. PMID:23089564
  • Cillo AR, Krishnan A, Mitsuyasu RT, McMahon DK, Li S, Rossi JJ, et al. Plasma Viremia and Cellular HIV-1 DNA Persist Despite Autologous Hematopoietic Stem Cell Transplantation for HIV-Related Lymphoma. JAIDS J Acquired Immune Defic Syndromes. 2013;63(4):438-41. PMID:23493152 PMCID:PMC3699958
  • Gallez-Hawkins, G.M., Franck, A.E., Xiuli, L., Thao, L., Oki, A., Gendzekhadze, K., Dagis, A., Palmer, J., Nakamura, R., Forman, S.J., Senitzer, D. and Zaia, J.A. Expression of activating KIR2DS2 and KIR2DS4 genes following hematopoietic cell transplant (HCT): relevance to cytomegalovirus (CMV) infection. antigen in patients with non-Hodgkin lymphoma. Leuk Lymphoma. 2013. PMID:21596150   PMCID:PMC3199314
  • Burnett JC, Zaia JA, Rossi JJ. Creating genetic resistance to HIV. Curr Opin Immunol 2012;24:625 PMID:22985479 PMCID:PMC3478429
  • Deeks, S.G., Autran, B., Berkhout, B., et.al. Towards an HIV cure: a global scientific strategy. Nat Rev Immunol 12, 2012: 607-614.  PMID:22814509 PMCID:PMC3595991
  • Guerrero, A., Riddell, S.R., Storek, J., Stevens-Ayers, T., Storer, B., Zaia, J.A., Forman, S., Negrin, R.S., Chauncey, T., Bensinger, W., and Boeckh, M. Cytomegalovirus Viral Load and Virus-Specific Immune Reconstitution after Peripheral Blood Stem Cell versus Bone Marrow Transplantation. Biology of Blood and Marrow Transplantation, 2012 18: 66-75. PMID:21664286 PMCID:PMC3237869
  • Israyelyan A, La Rosa C, Tsai W, Kaltcheva T, Srivastava T, Aquino L, Li J, Kim Y, Palmer J, Streja L, Senitzer D, Zaia JA, Rosenwald A, Forman SJ, Nakamura R, Diamond DJ.  Detection and preliminary characterization of CD8+T lymphocytes specific for Wilms' tumor antigen in patients with non-Hodgkin lymphoma. Leuk Lymphoma 2013;54:2490-9. PMID:23480492 PMCID:PMC3795970
  • Behrendt CE, Zaia JA,  In Vivo Evidence Insufficient to Conclude that "KIR/HLA Incompatibility Between Sexual Partners Confers Protection Against HIV-1 Transmission" Blood. 2013 Sep 12;122(11):1983-4. PMID:24030258 PMCID:PMC3772502

Last updated 09 May 2014.

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