Contact Information
John A. Zaia, M.D.
  • Aaron D. Miller and Edith Miller Chair in Gene Therapy
  • Chair and Professor, Virology
  • Institutional Official
  • Professor of Pediatrics

Research Areas
  • CMV Immunology
  • HIV-I Gene Therapy

Professional Experience

  • 2009 - present, Institutional Official, City of Hope, Duarte, CA
  • 1999 - present, Chair, Department of Virology, Beckman Research Institute of City of Hope, Duarte, CA
  • 1998 - present, Director, City of Hope General Clinical Research Center Satellite of USC School of Medicine (GCRC), Los Angeles, CA
  • 1980 - present, Director of Virology and Infectious Diseases, Department of Pediatrics, City of Hope
  • 1976 - 1980, Instructor in Medicine, Harvard Medical School; Clinical Associate, Dana Farber Cancer Institute, Boston, MA
  • 1974 - 1977, Fellow in Infectious Diseases, Beth Israel Hospital and Children’s Hospital Medical Center, Boston, MA; Fellow in Infectious Diseases, Dana Farber Cancer Institute, Boston, MA
  • 1971 - 1974, Senior Assistant Surgeon, United States Public Health Service, Virology Division, Laboratory Bureau, Center for Disease Control, Atlanta, GA
  • 1968 - 1971, Intern/Resident, St. Louis Children’s Hospital, St. Louis, Missouri and Children’s Hospital Medical Center, Boston, MA


  • 1968, Harvard University, Boston, MA, M.D., Medicine
  • 1966, Dartmouth College, Hanover, NH, B.M.Sc., Medicine
  • 1964, Holy Cross College, Worchester, MA, A.B., Biology


  • 2008, Aaron D. and Edith Miller Chair in Gene Therapy, Beckman Research Institute of City of Hope
  • 1977, Young Investigator Award, National Institute of Allergy and Infectious Diseases

Clinical Trials

  • Clinical Trials


  • City of Hope - Main Campus (Duarte)
    1500 East Duarte Road
    Duarte, CA 91010


Selected Publications
  • Li L, Krymskaya L, Wang J, et al. Genomic editing of the HIV-1 coreceptor CCR5 in adult hematopoietic stem and progenitor cells using zinc finger nucleases. Mol Ther 2013;21:1259-69. PMID:23587921 PMCID:PMC3677314
  • Behrendt CE, Nakamura R, Forman SJ, Zaia JA. Donor killer immunoglobulin-like receptor genes and reactivation of cytomegalovirus after HLA-matched hematopoietic stem-cell transplantation: HLA-C allotype is an essential cofactor. Frontiers in Immunology. 2013;4. PMID:23440333 PMCID:PMC3578282
  • Petz, L.D., Redei, I., Bryson, Y., Regan, D., Kurtzberg, J., Shpall, E., Gutman, J., Querol, S., Clark, P., Tonai, R., Santos, S., Bravo, A., Spellman, S., Gragert, L., Rossi, J., Li, S., Li, H., Senitzer, D., Zaia, J., Rosenthal, J., Forman, S., and Chow, R. Hematopoietic Cell Transplantation with Cord Blood for Cure of HIV Infections. Biology of Blood and Marrow Transplantation, 2013:9, 393-397. PMID:23089564
  • Cillo AR, Krishnan A, Mitsuyasu RT, McMahon DK, Li S, Rossi JJ, et al. Plasma Viremia and Cellular HIV-1 DNA Persist Despite Autologous Hematopoietic Stem Cell Transplantation for HIV-Related Lymphoma. JAIDS J Acquired Immune Defic Syndromes. 2013;63(4):438-41. PMID:23493152 PMCID:PMC3699958
  • Gallez-Hawkins, G.M., Franck, A.E., Xiuli, L., Thao, L., Oki, A., Gendzekhadze, K., Dagis, A., Palmer, J., Nakamura, R., Forman, S.J., Senitzer, D. and Zaia, J.A. Expression of activating KIR2DS2 and KIR2DS4 genes following hematopoietic cell transplant (HCT): relevance to cytomegalovirus (CMV) infection. antigen in patients with non-Hodgkin lymphoma. Leuk Lymphoma. 2013. PMID:21596150   PMCID:PMC3199314
  • Burnett JC, Zaia JA, Rossi JJ. Creating genetic resistance to HIV. Curr Opin Immunol 2012;24:625 PMID:22985479 PMCID:PMC3478429
  • Deeks, S.G., Autran, B., Berkhout, B., Towards an HIV cure: a global scientific strategy. Nat Rev Immunol 12, 2012: 607-614.  PMID:22814509 PMCID:PMC3595991
  • Guerrero, A., Riddell, S.R., Storek, J., Stevens-Ayers, T., Storer, B., Zaia, J.A., Forman, S., Negrin, R.S., Chauncey, T., Bensinger, W., and Boeckh, M. Cytomegalovirus Viral Load and Virus-Specific Immune Reconstitution after Peripheral Blood Stem Cell versus Bone Marrow Transplantation. Biology of Blood and Marrow Transplantation, 2012 18: 66-75. PMID:21664286 PMCID:PMC3237869
  • Israyelyan A, La Rosa C, Tsai W, Kaltcheva T, Srivastava T, Aquino L, Li J, Kim Y, Palmer J, Streja L, Senitzer D, Zaia JA, Rosenwald A, Forman SJ, Nakamura R, Diamond DJ.  Detection and preliminary characterization of CD8+T lymphocytes specific for Wilms' tumor antigen in patients with non-Hodgkin lymphoma. Leuk Lymphoma 2013;54:2490-9. PMID:23480492 PMCID:PMC3795970
  • Behrendt CE, Zaia JA,  In Vivo Evidence Insufficient to Conclude that "KIR/HLA Incompatibility Between Sexual Partners Confers Protection Against HIV-1 Transmission" Blood. 2013 Sep 12;122(11):1983-4. PMID:24030258 PMCID:PMC3772502
Last updated 18 November 2013.