Contact Information
John Termini, Ph.D.
  • Professor, Molecular Medicine

Biography

 
John Termini received his B.A. from Columbia College in New York City; then the M.S., M.Phil. and Ph.D. degrees from the department of Chemistry at Columbia University. His graduate training was in natural products chemistry and biochemistry under the tutelage of Prof. Koji Nakanishi; followed by postdoctoral training at Caltech in nucleic acids chemistry in the laboratory of Professor Peter B. Dervan, where he was a Fellow of the American Cancer Society.

Education

 
     Education/Training
 
  • 1985     Columbia College, New York      Ph.D. Chemistry
  • 1981     Columbia College, New York      M.S.   Chemistry
  • 1980     Columbia College, New York      B.A.    Chemistry
 

Honors/Awards

 
  Awards
 
  • 2011                   Cancer Research Award, ThinkCure
  • 1994 - 1995      American Lung Association Young Investigator Award
  • 1985                   NIH Postdoctoral Fellowship Award   Columbia University
  • 1982 - 1983      National Research Service Award Trainee

  Honors
 
  • 2006 - present   Editorial Board, BioScience Trends, Japan
  • 1986 - 1988        American Cancer Society Postdoctoral Fellow
  • 1979                     NSF-URP Fellowship, University of Oklahoma
 

Memberships

 
  • 2000 - present     American Chemical Society Division of Toxicology
  • 1990 - present     Member, City of Hope Cancer Center, Duarte, CA
  • 1980 - present     American Chemical Society

Publications

 
 
  • Neman, J., Termini, J., Wilczynski, S., Vaidehi, N., Choy, C., Kowolik, CM., Li, H., Hambrecht, AC., Roberts, E., Jandia, R. (2014). "Human breast cancer metastases to the brain display GABAergic properties in the neural niche" Proc Natl Acad Sci U.S.A., 111(3):984-9. PMCID:PMC3903266
  • Xin, H., Lu, R., Lee, H., Zhang, W., Zhang, C., Deng, J., Liu, Y., Shen, S., Wagner, KU., Forman, S., Jove, R., Yu, H. (2013). "G-protein-coupled receptors agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells" J Biol Chem, 288(19):13842-9. PMCID:PMC3650420
  • Distler, M.G., Gorfinkle, N., Papale, L.A., Wuenschell, G.E., Termini, J., Escayg, A., Winawer, M.R., & Palmer, A.A. (2013). “Glyoxalase 1 and its substrate methylgloxal are novel regulators of seizure susceptibility” Epilepsia, 54(4):649-57.  PMCID: PMC3618549
  • Jandial, R., Neman, J., & Termini, J. (2012). “Genetic mutations and tissue type lead to heterogeneous metabolic profiles in tumors” Neurosurgery, 70(6):N20-1. PMID: 22596009
  • Distler, M.G., Plant, L.D., Sokoloff, G., Hawk, A.J., Aneas, I., Wuenschell, G.E., Termini, J., Meredith S.C., Nobrega, M.A., & Palmer, A.A. (2012). “Glyoxalase 1 increases anxiety by reducing GABAA receptor agonist methylglyoxal” J Clin Invest, 122(6):2306-2315. PMCID: PMC3366407
  • Lim, P., Mahammed, A., Okun, Z., Saltsman, I., Gross, Z., Gray, H.B., & John Termini. (2012). “Differential Cytostatic and Cytotoxic Action of Metallocorroles against Human Cancer Cells: Potential Platforms for Anticancer Drug Development” Chem Res Toxicol, 25(2):400-9.  PMID: 22185566
  • Tamae, D., Lim, P., Wuenschell, G.E., & John Termini. (2011). “Mutagenesis and Repair Induced by the DNA Advanced Glycation End Product N2-1-(Carboxyethyl)-2’-deoxyguanosine in Human Cells” Biochemistry, 50(12):2321-2329.  PMCID: PMC3384727
  • Wuenschell, G.E., Tamae, D., Cercillieux, A., Yamanaka, R., Yu, C., & John Termini. (2010). “Mutagenic Potential of DNA Glycation: Miscoding by (R) and (S)-N2-(1-Carboxyethyl)-2’-Deoxyguanosine” Biochemistry, 49(9):1814-1821.  PMCID: PMC3446853
  • Synold, T., Xi, B., Wuenschell, G.E., Tamae, D., Figarola, J.L., Rahbar, S., & Termini, J. (2008). "Advanced Glycation End Products of DNA: Quantification of N2-(1-carboxyethyl)-2'-deoxyguanosine (CEdG) in Biological Samples by LC-ESI-MS/MS” Chem Res Toxicol, 21(11):2148-2155.  PMCID: PMC3253819
  • Yamanaka, R. & Termini, J. (2007). “Nucleotide sequence context influences HIV replication fidelity by modulating reverse transcriptase binding and product release” BioScience Trends, 1(1):52-61.  PMID: 20103867
  • Baker, D.J., Wuenschell, G.E., Xia, L., Termini, J., Bates, S.E., Riggs, A.D., & O’Connor, T.R. (2007). “Nucleotide Excision Repair Eliminates Unique DNA-Protein Cross Links from Mammalian Cells“ J Biol Chem, 282(31):22592-22604.  PMID: 17507378
  • Stiller, M., Green, R.E., Ronan, M., Simons, J.F., Du, L., He, W., Egholm, M., Rothberg, J.M., Keats, S.G., Ovodov, N.D., Antipina, E.E., Baryshnikov, G.F., Kuzmin, Y.V., Vasilevski, A.A., Wuenschell, G.E., Termini, J., Hofreiter, M., Jaenicke-Després, V., & Pääbo, S. (2006). “Patterns of nucleotide misincorporations during enzymatic amplification and direct large-scale sequencing of ancient DNA” Proc Natl Acad Sci, 103(40):14977.  PMCID:PMC1564221
  • Lim, P., Wuenschell, G.E., Holland, V., Lee, D.H., Pfeifer, G.P., Rodriguez, H., & Termini, J. (2004). “Peroxy radical mediated oxidative DNA base damage-implications for lipid peroxidation induced mutagenesis.” Biochemistry, 43(49):15339-15348.  PMID: 15581346
  • Lim, P., Sadre-Bazzaz, K., Shurter, J., Sarasin, A., & Termini, J. (2003). “DNA damage and mutations induced by arachidonic acid peroxidation” Biochemistry, 42(51):15036-15044.  PMID: 14690412
  • Termini, J. (2003). Peroxyl and Alkoxyl radical mediated DNA damage. In: Culter, R.G. & Rodriguez, H. editors. Oxidative Stress and Aging: Advances in Basic Science, Diagnostics, and Intervention. Vol 1. River Edge, NJ: World Scientific Publishing Company, 40-53.
  • Wuenschell, G.E., O'Connor, T.R., & Termini, J. (2003). "Stability, miscoding potential and repair of 2'deoxyxanthosine in DNA:  Implications for nitric oxide-induced mutagenesis" Biochemistry, 42(12):3608-3616.  PMID: 12653565
  • Dussault, I., Lin, M., Hollister, K., Fan, M., Termini, J., Sherman, M.A., & Forman, B.M. (2002). “A structural model of the constitutive androstane receptor defines novel interactions that mediate ligand-independent activity” Mol Cell Biol, 22(15):5270-80. PMCID: PMC133936
  • Wuenschell, G.E., Valentine, M.R., & Termini, J. (2002). "Incorporation of oxidatively modified 2’-deoxynucleotide triphosphates by HIV-1 RT: on RNA and DNA templates” Chemical Res Toxicol, 15(5):654-661.  PMID: 12018986
  • Valentine, M.R. & Termini, J. (2001). “Kinetics of formation of hypoxanthine containing base pairs by HIV-RT: RNA template effects on the base substitution frequencies” Nucleic Acids Research, 29(5):1191-1199.  PMCID: PMC29738
  • Yean, S.L., Wuenschell, G.E., Termini, J., & Lin, R.J. (2000). "Metal-ion coordination by U6 small nuclear RNA contributes to catalysis in the spliceosome." Nature, 408(6814):881-884.  PMID: 11130730 NIHMS308978
  • Rodriguez, H., Valentine, M.R., Holmquist, G.P., Akman, S.A., & Termini, J. (1999). “Mapping of Peroxy Radical Induced Damage on Genomic DNA” Biochemistry, 38(50):16578-16588.  PMID: 10600120
  • Li, S., Termini, J., Hayward, A., Siddle, K., Zick, Y., Koval, A., LeRoith, D., & Fujita-Yamaguchi, Y. (1998). “The carboxyl-terminal domain of insulin-like growth factor-I receptor interacts with the insulin receptor and activates its protein tyrosine kinase” FEBS Letters, 421(1): 45-49. PMID: 9462837
  • Martini, M., & Termini, J. (1997). “Peroxyl radical oxidation of thymidine” Chem Res Toxicol, 10(2):234-241.  PMID: 9049436
  • Rhee, Y., Valentine, M.R., & Termini, J. (1995). “Oxidative base damage in RNA detected by reverse transcriptase” Nucleic Acids Res, 23(16):3275-3282.  PMCID: PMC307188
  • Deng, H.Y., & Termini, J. (1992). “Catalytic RNA reactions of yeast tRNAPhe fragments” Biochemistry, 31(43):10518-28.  PMID: 1329951
  • Turner, C.J, Tempesta, M.S., Taylor, R.B., Zagorski, M.G., Termini, J., Schroeder, D.R., & Nakanishi, K. (1987). “An NMR spectroscopic study of azadirachtin and its trimethyl ether” Tetrahedron, 43(12):2789-2803. DOI: 10.1016/S0040-4020(01)86885-X
  • Eisenstein, L., Lin, S.L., Dollinger, G., Odashima, K., Termini, J., Konno, K., Ding. W.D. & Nakanishi, K. (1987). “FTIR Difference studies on apoproteins. Protonation states of aspartic and glutamic acid residues during the photocycle of Bacteriorhodopsin” J Am Chem Soc, 109(22):6860-6862.
  • Dollinger, G., Eisenstein, L., Lin, S.L., Nakanishi, K., & Termini, J. (1986). “Fourier transform infrared difference spectroscopy of Bacteriorhodopsin and its photoproducts regenerated with deuterated tyrosine” Biochemistry, 25(21):6524-6533.  PMID:3790539
  • Termini, J. (1983). Chemical conversions of penicillins to cephalosporins. In: Koji Nakanishi, Toshio Goto, Sho Ito, Shinsaku Natori Shigeo Nozoe, editors. Natural Products Chemistry. Vol. 3. Mill Valley, CA: University Science Books, 630-634.
  • Croteau, A.A., & Termini, J. (1983). “A convenient route to α,β-unsaturated methyl ketones application to retinal analogue synthesis” Tetrahedron Letters, 24(24):2481-2484. DOI: 10.1016/S0040-4039(00)81960-7
 

Locations

 
  • City of Hope - Main Campus (Duarte)
    1500 East Duarte Road
    Duarte, CA 91010