Contact Information
Rama Natarajan, Ph.D, F.A.H.A, F.A.S.N.
  • Professor and Associate Chair, Department of Diabetes and Metabolic Diseases Research
  • National Business Products Industry Professor, Department of Diabetes and Metabolic Diseases Research
  • Director, Division of Molecular Diabetes Research
  • Member, Molecular Oncology Program, Comprehensive Cancer Center

Professional Experience

  • 2011 - present, National Business Products Industry Professor, Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute of City of Hope, Duarte, CA
  • 2011 - present, Director, Division of Molecular Diabetes Research, Beckman Research Institute of City of Hope, Duarte, CA
  • 2002 - present, Professor, Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute of City of Hope, Duarte, CA
  • 1996 - 2001, Associate Professor, Dept of Diabetes, Beckman Research Institute of City of Hope, Duarte, CA
  • 1990 - 1996, Assistant Research Scientist, Dept. of Diabetes, City of Hope, Duarte, CA
  • 1987 - 1990, Assistant Professor, Dept. of Medicine, University of Southern California Medical School, Los Angeles, CA

Education

Education/Training
  • 1980-1986, NIH Post Doctoral Fellow, Dept. of Medicine, University of Southern California Medical School, Los Angeles, CA
  • 1979-1980, Scientific Research Council Post Doctoral Fellow, Dept. of Applied Chemistry, Salford University, England, U.K.
  • 1977-1979, Senior Research Fellow, Dept of Science and Technology fellowship, Indian Institute of Science, Bangalore, India
  • 1973-1977, Ph.D in Biochemistry, Indian Institute of Science, India

Honors/Awards

Awards
  • 2011, Mentor of Women Award, ATVB Council of The American Heart Association
  • 2011, Inducted to the Scientific Research Achievements Gallery of Portraits, City of Hope – December
  • 2008, “Scientist of the Year” 2008 - Awarded by Beckman Research Institute of City of Hope
  • 2008, American Heart Association, ATVB Council, Special Recognition Award
  • 2006, Mary Jane Kugel Award, Juvenile Diabetes Research Foundation
  • 2003, “Excellence in Teaching” Award , Graduate School of Biological Sciences, Beckman Research Institute of City of Hope
  • 1992, Best Presentation Award presented by the American Diabetes Association, Southern California
  • 1992, Losartan Research Award presented by DuPont Merck – April
  • 1992, Young Investigator Award, American Heart Association – January
  • 1991, Henry Christian Award for "Excellence in Research". Presented by the American Federation For Clinical Research - May

Honors
  • 2012, Robert R. Kohn Memorial Lecture, Case Western Reserve University, School of Medicine, Cleveland Ohio - December
  • 2012, Kroc Lectureship, Baylor College of Medicine, Department of Endocrinology and Medicine - October
  • 2012, Lead organizer, Keystone Meeting on Diabetic Complications, Boston, MA - March
  • 2011, National Office Products Endowed Professor, Beckman Research Institute of City of Hope
  • 2011, Plenary Speaker, Korean Society of Nephrology 31st Annual Meeting, Seoul, Korea - May
  • 2010, Barry M Brenner Endowed Lecture, American Society of Nephrology, Denver, CO - November
  • 2010, Annual Henry Turner Memorial Lecture and Distinguished Professor. University of Oklahoma, Dept of Internal Medicine, Oklahoma City, OK - February
  • 2006, Elected as Chair of the Women’s Leadership Committee, Arteriosclerosis, Thrombosis Vascular Biology Council, American Heart Association
  • 2004, Elected Fellow of the American Society of Nephrology
  • 2004, Elected to the Western Association of Physicians
  • 2003 to date, Editorial Boards of Kidney International, J. Lipid Research, DIABETES; American Journal of Physiology, Renal Physiology
  • 2001, Elected Fellow of Arteriosclerosis, Thrombosis Vascular Biology Council, American Heart Association

Memberships

  • 2011, Adhoc Member, National Institutes of Health AICS Study Section
  • 2012, AdHoc Member, National Institutes of Health VCMB Study Section
  • 2009, Member of the NIH NIDDK Strategic Plan Working Group (Diabetes Complications Section)
  • 2004 - 2008, Permanent Member National Institutes of Health VCMB Study Section
  • 2003 - 2012, Permanent Member JDRF Peer Review Committee for Grants and Program Projects
  • 2008, AdHoc Member National Institutes of Health NIDDK Special Emphasis Panel Review Committee “O’Brien Kidney Center Grants”.
  • 2007, AdHoc Member National Institutes of Health AICS Study Section
  • 2007, AdHoc Member JDRF Center Grant External Evaluation Committee
  • 2006, AdHoc Member National Institutes of Health PBKD Study Section
  • 2006, AdHoc Member National Institutes of Health NIDDK Special Emphasis Panel for Mouse Model Phenotyping Centers Consortium
  • 2005, AdHoc Member National Institutes of Health AICS Study Section
  • 2004, AdHoc Member National Institutes of Health PBKD Study Section
  • 2003, AdHoc Member National Institutes of Health Nephrology/Urology Special Emphasis Panel
  • 2003, AdHoc Member National Institutes of Health Program Projects, NIDDK
  • 1999 - 2003, Permanent Member National Institutes of Health Path A Study Section
  • 2001 - 2002, AdHoc Member National Institutes of Health NIDDK O’Brien Kidney Center Grants
  • 2001, AdHoc Member National Institutes of Health NHLBI SCOR Grant Review Committee
  • 1999, AdHoc Member National Institutes of Health Pathology A Study Section

Publications

  • “PARTIAL LIST OF PUBLICATIONS”
  • Kato M, Wang M, Park JT, Deshpande, Mardiros A, Dang V, Zhan Y, Oettgen P, Putta S, Lanting L, Natarajan R. (2013). TGF-β Induces Acetylation of Chromatin and of Ets-1 to Alleviate Repression of miR-192 in Diabetic Nephropathy. Science Signaling (In Press).
  • Leung A, Trac C, Lanting L, Schones DE, and Natarajan R. (2013) Novel long non-coding RNAs are involved in cellular response to Angiotensin II-signaling. Circulation Res. (In Press).
  • Miao F, Chen Z, Zhang L, Gao H and Natarajan R. (2013) RNA-Sequencing Analysis of High Glucose Treated Monocytes Reveals Novel Transcriptome Signatures and associated Epigenetic Profiles. Physiol Genomics. Apr 1;45(7):287-99.
  • Yuan H, Sun G, Lanting L, Wang M, Arce L, Kato M, Kato M and Natarajan R. (2013) Involvement of CBP/P300 and epigenetic histone acetylation in TGF-β1/Smad-pathway mediated gene transcription in mesangial cells Am. J. Physiol (Renal) 304:F601-13.
  • Park JT, Kato M, Yuan H, Castro N, Lanting L, Wang M and Rama Natarajan. (2013) FOG2 down-regulation by TGF-β-induced microRNA-200b/c leads to Akt kinase activation and Glomerular Mesangial Hypertrophy Related to Diabetic Nephropathy. J. Biol. Chem (In Press).
  • Deshpande SD, Putta S, Wang M, Lai JY, Bitzer M , Nelson RG, Lanting LL, Kato M and Natarajan R. (2013) Transforming Growth Factor-β induced cross talk between p53 and a microRNA in the pathogenesis of Diabetic Nephropathy. DIABETES (In Press).
  • Putta S, Lanting L, Sun G, Lawson G, Kato M and Natarajan R . Inhibiting MicroRNA-192 Ameliorates Renal Fibrosis in Diabetic Nephropathy. (2012). J. Am. Soc. Nephrol. Mar;23(3):458-69.
  • Miao F, Chen Z, Zhang L, Liu Z, Wu X, Yuan Y-C and Natarajan R. (2012) Profiles of Epigenetic Histone Post-translational Modifications at Type 1 Diabetes Susceptible Genes. 2012. J. Biol. Chem . May 11;287(20):16335-45.
  • Jin W, Reddy MA, Chen Z, Putta S, Lanting L, Kato M, Park JT, Chandra M, Tangirala R, and Natarajan R. (2012). Small RNA Sequencing Reveals MicroRNAs That Modulate Angiotensin II Effects in Vascular Smooth Muscle Cells. J. Biol. Chem. May 4;287(19):15672-83.
  • Reddy MA, Wen J, Villeneuve L, Wang M, Lanting M, Todorov I, Kato M and Natarajan R. (2012). Pro-Inflammatory Role of microRNA-200 in Vascular Smooth Muscle Cells from Diabetic Mice. Arterioscler Thromb Vasc Biol Mar;32(3):721-9. Epub (2012) Jan 12. PMCID: PMC3288534.
  • Natarajan R, Putta S, Kato M (2012). MicroRNAs and Diabetic Complications. Special Focus Issue. Journal of Cardiovascular Translational Research Aug;5(4):413-22. PMCID:PMC3396726.
  • Villeneuve LM, Reddy MA, Natarajan R. (2011) Epigenetics: Deciphering its role in Diabetes and its Chronic Complications. Clin Exp Pharmacol Physiol. Jul;38(7):401-9.
  • Kato M, Arce L, Wang M, Putta S, Lanting L, and Natarajan R. (2011) A microRNA circuit mediates transforming growth factor-β1 autoregulation in renal glomerular mesangial cells. Kidney International 2011 Aug;80(4):358-68 (Comment in the same issue of Kid Intl pg 334-337).
  • Jin F, Li Y, Ren B, Natarajan R. (2011) PU.1 and C/EBPa synergistically program distinct response to NF-κB activation through establishing monocyte-specific enhancers. Proc. Natl Acad. Sci USA. 108 (13): 5290-5295. PMID: 21402921; PubMed Central PMCID: PMC3069155.
  • Meng L*, Park J*, Cai Q*, Lanting L, Reddy MA and Natarajan R. (2010) Diabetic Conditions Promote Binding of Monocytes to Vascular Smooth Muscle Cells and their Subsequent Differentiation. Am. J. Physiol. Heart Circ Physiol. 298(3):H736-45. (*equal contribution) (Editorial in same issue, H731).
  • Villeneuve LM, Kato M, Wang M, Reddy MA, Lanting L, Natarajan R. (2010). Enhanced microRNAs-125b levels in vascular smooth muscle cells of diabetic mice leads to increased inflammatory gene expression by targeting the histone methyltransferase Suv39h1. Diabetes. 59(11):2904-15.
  • Villenueve LM and Natarajan R. (2010) The Role of Epigenetics in the Pathology of Diabetic Complications. American Journal of Physiology, Renal. 299: F14–F25.
  • Kato M, Wang L, Putta S, Wang M, Yuan H, Sun G, Lanting L, Todorov I, Rossi JJ, and Natarajan R. (2010). Post-transcriptional upregulation of Tsc-22 by Ybx1, a target of miR-216a, mediates TGF-β –induced collagen expression in renal cells. J.Biol.Chem. 285(44):34004-15. Paper of the Week - top 1% of papers.
  • Sun G, Reddy MA, Yuan H, Lanting L, Kato M, and Natarajan R. (2010). Epigenetic histone methylation modulates fibrotic gene expression in mesangial cells.J. Am. Soc. Nephrol. 21(12):2069-80 (PMCID: 3014020).
  • Kato M, Wang M, Yuan H, Lanting L, Putta P, Gunn A, Nakagawa Y, Shimano H, Rossi JJ and Natarajan R. (2009) TGF-beta activates Akt kinase via a microRNA-dependent amplifying circuit argeting PTEN. Nature Cell Biology 11:881-889. (Faculty of 1000).
  • Villeneuve LM, Reddy MA, Lanting L, Wang M, Meng L, Natarajan R. (2008) Epigenetic Histone H3 Lysine 9 Methylation in Metabolic Memory and Inflammatory Phenotype of Vascular Smooth Muscle Cells in Diabetes. Proc. Natl Acad Sci USA 105(26):9047-52.
  • Yuan H, Lanting L, Xu ZG, Wang M, Li SL, Swiderski P, Putta S, Jonnalagadda M, , Kato M and Natarajan R. (2008) Effects of Cholesterol tagged short interfering RNAs targeting 12/15-lipoxygenase on parameters of diabetic nephropathy in a mouse model of type 1 diabetes. Am. J. Physiol. (Renal) 295(2):F605-F617.
  • Li Y, Reddy MA, Miao F, Shanmugam N, Yee JK, Hawkins D, Ren B, Natarajan R. (2008) Role of the histone lysine methyltransferase SET7/9 in the regulation of NF-kB-dependent inflammatory genes. J. Biol. Chem. 283:26771-26781.
  • Miao F, David D. Smith†, Lingxiao Zhang*, Andrew Min*, Wei Feng*, Natarajan R. (2008) Lymphocytes from Patients with Type 1 diabetes Reveal a Distinct Profile of Chromatin Histone H3 Lysine 9 Dimethylation: An Epigenetic Study in Diabetes. Diabetes. 57:3189-3198. Commentary in the same issue on page 3184 by Litherland SA.
  • Shanmugam N, Reddy MA, Natarajan R. (2008) Distinct Roles of hnRNPK and microRNA-16 in S100b Induced Cyclooxygenase-2 mRNA Stability in Monocytes. J. Biol.Chem, 283(52):36221-33. Paper of the Week. Comment in the same issue.
  • Kato M, Zhang J, Wang M, Yuan H, Rossi JJ, Natarajan R. (2007) MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors. Proc. Natl. Acad. Sci. USA. 104:3432-3437.
  • Miao F, Wu X, Zhang L, Yuan Y-C, Riggs A, Natarajan R. (2007) Genome-wide Analysis of Histone Lysine Methylation variations under diabetic conditions in human monocytes. J. Biol. Chem. 282:13854-13863.

Clinical Trials

Locations

  • City of Hope - Main Campus (Duarte)
    1500 East Duarte Road
    Duarte, CA 91010