Contact Information
Theodore G. Krontiris, M.D., Ph.D.
  • Professor, Molecular Medicine
  • Director Emeritus, Comprehensive Cancer Center

Languages Spoken
  • English

Biography

Theodore Krontiris, MD, PhD, joined City of Hope (COH) in 1996 as chair of a newly established Department of Molecular Medicine; he was Executive Vice President, Medical and Scientific Affairs, and Director of COH’s NCI-designated Comprehensive Cancer Center from 2001 to 2007.  Prior to coming to COH, Dr. Krontiris held several medical and teaching positions at Tufts University School of Medicine and Tufts New England Medical Center Hospitals, where he was founding director of the Graduate Program in Genetics at the Sackler Graduate School.  He received his medical degree and PhD from the Albert Einstein College of Medicine in New York, as well as residency and fellowship training at Brigham and Women’s Hospital and the Dana-Farber Cancer Institute in Boston.

Professional Experience

  • 2007 - present, Director Emeritus, City of Hope Comprehensive Cancer Center
  • 2001 - 2007, Director, City of Hope Comprehensive Cancer Center. Executive Vice President for Medical and Scientific Affairs.
  • 1999, Associate Director for Cancer Control and Prevention Research, City of Hope Comprehensive Cancer Center
  • 1996, Director, Department of Molecular Cancer Genetics, Beckman Research Institute of City of Hope; Consulting Physician, Department of Hematology, City of Hope
  • 1996 - present, Professor, Division of Molecular Medicine, Beckman Research Institute of City of Hope, Duarte, CA; Member, City of Hope Comprehensive Cancer Center
  • 1996 - 2001, Chair, Division of Molecular Medicine, Beckman Research Institute of City of Hope
  • 1996, Professor of Medicine, TUSM
  • 1996, Founding Director, Graduate Program in Genetics, Sackler School of Graduate Biomedical Sciences, TUSM
  • 1991 - 1996, Physician, NEMCH
  • 1991 - 1996, Associate Professor of Medicine, TUSM NEMCH
  • 1984 - 1996, Member, Graduate Immunology Faculty, Tifts University School of Medicine
  • 1982 - 1991, Assistant Professor, Department of Medicine (Hematology Oncology), Tufts New England Medical Center Hospitals
  • 1982 - 1991, Assistant Physician, New England Medical Center Hospitals, Boston, MA
  • 1981 - 1982, Instructor, Department of Medicine, Harvard Medical School, Boston, MA

Education

Education/Training
  • 1978 - 1982, Dana Farber Cancer Institute, Boston, MA, Molecular Biology
  • 1977 - 1981, Brigham and Women's Hospital, Boston, MA, Internal Medicine
  • 1969 - 1977, Albert Einstein College of Medicine, Bronx, N.Y, M.D., Ph.D. Medicine, Cell Biology
  • 1964 - 1968, University of Chicago, Chicago, IL, S.B. Mathematics

Honors/Awards

Awards
  • 1987 - 1991, Faculty Research Award, American Cancer Society
  • 1983 - 1986, Hartford Foundation Fellowship
  • 1981 - 1982, NIH Postdoctoral Fellowship
  • 1979 - 1980, Damon Runyon Walter Winchell Cancer Fund Postdoctoral Fellowship

Honors
  • 1991, American Society for Clinical Investigation

Memberships

  • 1999, Ad hoc Advisory Council, NCI National Cancer Genetics Network
  • 1999 - present, Human Genetics Committee, Eastern Cooperative Oncology Group; Chairman
  • 1999 - 2002, Editorial Board, Journal of Clinical Oncology
  • 1998 - present, Medical Genetics Peer Review Panel, U.S. Army Breast Cancer Program
  • 1989 - 1993, NIH Mammalian Genetics Study section
  • Fellow, Environmental Health Institute
  • American Society of Human Genetics
  • American Society for Microbiology
  • American Society of Clinical Oncology
  • American Society of Hematology
  • Member, Grants Advisory Council, Arnold and Mabel Beckman Foundation

Publications

  • Ouyang C, Krontiris TG. Identification and functional significance of SNPs underlying conserved haplotype frameworks across ethnic populations. Pharmacogenetics and Genomics 2006; 16:667-82.
  • Larson, G, Ding Y, Cheng L, et al. Genetic linkage of prostate cancer risk to the chromosome 3 region bearing FHIT. Cancer Res 2005; 65:805-814.
  • Song J, Durrin LK, Wilkinson TA, Krontiris TG, and Chen Y. Identification of a SUMO-binding motif that recognizes SUMO-modified proteins. Proc Natl Acad Sci (USA) 2004; 101:14373-14378.
  • Sun Y, Durrin L, Krontiris TG. Specific interaction of PML bodies with the TP53 locus in Jurkat interphase Nuclei. Genomics 2003, 82: 250.
  • Durrin, L, Krontiris TG. The thymocyte-specific MAR binding protein, SATB1, interacts exclusively with a novel variant of the DNA-directed RNA polymerase II, subunit 11. Genomics 2002; 79:809.
  • Beaulieu M, Larson G, Flanagan S, Krontiris TG. Candidate Region Mismatch Scanning (PCR-CRMS): Adaptationto quantitative, high-throughput genotyping. Nucl Acids Res 2001, 29:1114.
  • Sun Y, Wyatt RT, Bigley A, Krontiris TG. Expression and Replication Timing Patterns of Translocated and Untranslocated Alleles of the BCL2 Gene. Genomics 2001, 73:161.
  • Weitzel JN, Ding S, Larson G, Nelson RA, Goodman A, Grendys EC, Ball HG, Krontiris TG. The HRAS1 Minisatellite and Risk of Ovarian Cancer. Cancer Res 2000; 60:259-261.
  • Ramakrishnan M, Liu W, DiCroce PA, Posner A, Zheng J, Kohwi-Shigematsu T, Krontiris TG. Modulated Binding of SATB1, a Matrix Attachment Region Protein, to the AT-rich Sequence Flanking the Major Breakpoint Regionof BCL2. Mol Cell Biol 2000; 20:868-877.
  • Larson G, Ding S, Lafreniere RG, Rouleau GA, Krontiris TG. Instability of the EPM1 Minisatellite. Hum Mol Genet 1999; 8:1985.
  • Ding S, Larson G, Zhang G, Foldenauer K, Flanagan S, Krontiris TG. Distinct Mutation Patterns of Breast Cancer Associated Alleles at the HRAS1 Minisatellite Locus. Hum Mol Genet 1999; 8:515
  • Larson GP, Zhang G, Ding S, Foldenauer K, Nudar N, Gatti R, Ruckdeschel JA, Lunetta K, Longmate J, Flanagan S, Krontiris TG. An Allelic Variant at the ATM Locus Is Implicated in Breast Cancer Susceptibility. Genetic Testing 1998; 1:165.
  • DiCroce PA, Krontiris TG. The BCL2 Major Breakpoint Region Is a Sequence- and Cell-Cycle-Specific Binding Site of the Ku Antigen. Proc. Natl. Acad. Sci. USA 1995; 92:10137.
  • Krontiris TG. Minisatellites and Human Disease. Science 1995; 269:1682.
  • Krontiris TG. Oncogenes. New Engl J Med 1995; 333:303.
  • Krontiris TG. HRAS1 Minisatellite Instability and Cancer Risk. J. Bertino, et al., eds. The Molecular Biology of Cancer. Academic Press, 1994.
  • Devlin B, Krontiris TG, Risch N. Population Genetics of the HRAS1 Minisatellite Locus. Am J Hum Genet 1993; 53:1298.
  • Krontiris TG, Devlin B, Robert NJ, Karp DD, Risch N. An Association between the Risk of Cancer and Mutations in the HRAS1 Minisatellite Locus. New Engl J Med 1993; 329:517.
  • Green M, Krontiris TG. Allelic Variation of Reporter Gene Activation by the HRAS1 Minisatellite. Genomics 1993; 17:429.
  • Trepicchio W, Krontiris TG. IGH Minisatellite Suppression of USF-Binding-Site- and Eµ-Mediated Transcriptional Activation of the Adenovirus Major Late Promoter. Nucl Acids Res 1993; 21:977.
  • Trepicchio W, Krontiris TG. Members of the rel/NF- B Family of Transcriptional Regulatory Factors Bind the HRAS1 Minisatellite DNA Sequence. Nucl Acids Res 1992; 20:2427.
  • Wyatt RT, Rudders RA, DeLellis RA, Zelenetz A, Krontiris TG. BCL2 Oncogene Translocation Is Mediated by a ? like Consensus Sequence. J Exp Med 1992; 175:1575.
  • Weston A, Vineis P, Caporaso NE, Krontiris TG, Lonergan JA, Sugimura H. Racial Variation in the Distribution of HRAS1 Alleles. Mol Carcinogenesis, 1991; 4:265.
  • Krontiris TG. Detection of Cancer Predisposition by Hypervariable Region Analysis. In: Spatz L, Bloom AD, Paul NW, eds. Detection of Cancer Predisposition: Laboratory Approaches. Monograph No. 3, Environmental Health Institute. March of Dimes Foundation. 1990. pp. 129 139.
  • Kasperczyk A, DiMartino NA, Krontiris TG. Allele Diversification at the HRAS1 Minisatellite Locus: The Origin of Rare HRAS1 Alleles. Am J Hu Genet 1990; 47:854.
  • Kasperczyk A, Mermer BA, Parkinson DR, Lonergan JA, Krontiris TG. Allele specific Deletion in Exon One of the Human HRAS1 gene. Am J Hu Genet 1989; 45:689.
  • Mermer BA, Colb M, Krontiris TG. A Family of Short, Interspersed Repeats is Associated with Tandemly Repetitive DNA in the Human Genome. Proc Natl Acad Sci (USA) 1987; 84:3320.
  • Aisenberg AC, Krontiris TG, Mak TW, Wilkes BM. The Gene for the Beta Chain of the T Cell Receptor is Rearranged in T Cell Chronic Lymphocytic Leukemia and Allied Disorders. New Engl J Med 1985; 313:529.
  • Krontiris TG, DiMartino NA, Colb M, Parkinson DR. Unique Allelic Restriction Fragments of the Human Ha ras Locus in Leukocyte and Tumor DNAs of Cancer Patients. Nature 1985; 313:369.
  • Krontiris TG. The Emerging Genetics of Human Cancer. New Engl J Med 1983; 309:413.
  • Der CJ, Krontiris TG, Cooper GM. Transforming Genes of Human Bladder and Lung Carcinoma Cell Lines are Homologous to the ras Genes of Harvey and Kirsten Sarcoma Viruses. Proc Natl Acad Sci (USA) 1982;79:3637.
  • Krontiris TG, Cooper GM. Transforming Activity of Human Tumor DNAs. Proc Natl Acad Sci (USA) 1981; 78:1181.
  • Krontiris TG, Soeiro, R, Fields, BN. Host Restriction of Friend Leukemia Virus: Role of the Viral Outer Coat. Proc Natl Acad Sci (USA) 1973; 71:2548.

Clinical Trials

Locations

  • City of Hope - Main Campus (Duarte)
    1500 East Duarte Road
    Duarte, CA 91010