Contact Information
Mike Y. Chen, M.D., Ph.D.
  • Assistant Professor

Primary Specialties

Departments/Division/Program

Biography

Dr. Mike Y. Chen is a surgeon/scientist at City of Hope National Medical Center. He specializes in complex operations for the removal of brain and spine tumors. His training has included a Masters in biomedical engineering from Johns Hopkins University, neurosurgical residency at the Virginia Commonwealth University Hospitals, a PhD in anatomy and neurobiology from Virginia Commonwealth University, and a fellowship at the National Institutes of Health. Dr. Chen has an active lab focused on developing next generation therapies for the treatment of cancers that have metastasized to the central nervous system. He has published over 50 papers, book chapters and books and has given numerous talks and lectures. Dr. Chen is the past president of the Society for Brain Mapping and Therapeutics.

Professional Experience

  • 2007 - present, Assistant Professor, Section head of malignant brain tumor program, Division of Neurosurgery, City of Hope, Duarte, CA
  • 2006, Assistant Professor, Department of Neurosurgery, Virginia Commonwealth University/Medical College of Virginia, Richmond, VA

Education

Education/Training
  • 2000 - 2006, Medical College of Virginia, / Virginia Commonwealth University Health System, Neurosurgery Residency, Ph.D., Anatomy and Neurobiology
  • 1997 - 2000, Research Fellowship, National Institutes of Health, Surgical Neurology Branch
  • 1996 - 1997, Johns Hopkins Hospital, Internship in Surgery
  • 1992 - 1994, Johns Hopkins University, M.S., Biomedical Engineering
  • 1988 - 1996, Pennsylvania State University, B.S., Thomas Jefferson University, M.D.- 6 year combined B.S., M.D. program

Board Certifications/Licensure
  • 2013, Neurosurgery

Honors/Awards

Awards
  • Margaret Early Trust Grant. Role of the Chromobox Protein CBX6 in the Mesenchymal Transition of Glioblastoma 2012. Principle Investigator.
  • Biomechanical evaluation of dual vertebral cages in the thoracic spine. Investigator Initiated Research. Globus Medical Grant. 2012
  • Golden Axon Award for Leadership and Dedication. Society for Brain Mapping and Therapeutics. June 2012
  • Characterizing the progenitor cell subpopulation in cancellous bone. Nuvasive. Industry Sponsored grant: $560,000. September 2010.
  • Biomechanical assessment of thoracic and lumbar vertebral column reconstruction with bilateral expandable cages. Globus Medical Corporation. Investigator Initiated Research: $10,000. August 2010
  • Named by Pasadena Magazine as one of the top neurosurgeons in Los Angeles in 2009, 2010, 2011, 2012, 2013
  • Biomechanical assessment of C2 vertebral column reconstruction with bilateral expandable cages. Globus Medical Corporation. Industry Sponsored Grant: $10,000. January 2010
  • 2nd place at 2nd Annual COH Poster Session, “Collaboration: Synergy for Success.” The Use of Tisseel as a Delivery Vehicle for Genetically Engineered Cytotoxic T Lymphocytes. Zhaoxia Zou, M.D., Erin Denny, Christine Brown, Ph.D., Araceli Hamlett, James Wang, Ph.D., Yufang Yin, Mike Chen, M.D., Ph.D.
  • Pilot Study: Characterizing the progenitor cell subpopulation in cancellous bone Nuvasive. Industry Sponsored Grant: $160,000. February 2010
  • NASA Tech Brief Award for NTR 45433: Use of JPL Electronic Nose for Detection of Tumors. 2008
  • 2007, NIH K 12 Grant for $500,000. The effect of stat3 inhibitors distributed using convection-enhanced delivery on cell death and chemoreistance in metastatic melanomas of the murine brain.
  • 2003, Crutchfield, Gage and Thomson award for best resident presentation at the annual meeting of the Neurosurgical society of the Virginias
  • 1999, Fellows Award for Research Excellence, National Institutes of Health
 

Memberships

  • American Association of Neurological Surgeons
  • Congress of Neurological Surgeons
  • The Johns Hopkins Medical & Surgical Association
  • International Brain Mapping and Intra-operative Surgical Planning Society: Board of Directors
  • City of Hope Cancer Center member: Developmental Therapeutics Program
  • Los Angeles County Medical Association
  • California Medical Association
  • American Association for Cancer Research
  • Society for Neuro-Oncology

Publications

  • Gang Li, James Wang, Dannie Angeles, Tats Fujii, Rahul Jandial, Byron Cheung, Kerin Higa, Trine Lillehammer, Janendar K. Batra, Mike Chen. Eradication of melanoma cells by Selective expression of the cytotoxin saporin using a Tissue specific promoter approach. (in preparation)
  • Gang Li; Charles Warden; Zhaoxia Zou; Josh Neman; Joseph S Krueger; Alisha Jain; Rahul Jandial; Mike Chen, M.D., Ph.D."Dysregulated expression of Polycomb group genes in glioblastoma multiforme. submitted
  • Russell Thompson, Sanjeet Dadwal, M.D, Rahul Jandial, M.D., Ph.D., *Mike Yue Chen, M.D., Ph.D. Chronic Central Nervous System Fungal Infection with Alternaria. (being revised)
  • Gang Li, Charles Warden, Zhaoxia Zou, Josh Neman, Alisha Jain, Rahul Jandial, Mike Chen. Dysregulated expression of Polycomb group genes in glioblastoma multiforme. Carcinogenesis (submitted)
  • Zhaoxia Zou, M.D., Yufang Yin, Li-chen Hsu, Vanessa Brandon, Fan Yang Ph.D, Richard Jove, Ph.D, Rahul Jandial, M.D., Ph.D., Gang Li, Ph.D, Mike Chen, M.D., Ph.D. STAT3 Inhibition Contributes to Cytotoxicity Induced by Convection-Enhanced Delivery of Sorafenib in a Murine Model of Brain Melanoma. (Submitted to clinical cancer research)
  • Mike Yue Chen, Martin R. Graf, Shawn E. Holt, Dana C. Chan, Aaron J. Clark, Timothy E. VanMeter, Archana Chidambaram, Helen L. Fillmore, William C. Broaddus. Autophagy due to BCNU or cisplatin treatment: Novel demonstration in glioma cells resistant to chemotherapy. (Submitted to Neurosurgery)
  • Jana Portnow, Behnam Badie, Xueli Liu, Paul Frankel, Shu Mi, Mike Chen, Timothy W. Synold. Changes in Intracerebral Cytokine Levels after Craniotomy and In Response to Treatment with Temsirolimus in Patients with Brain Tumors: A Pilot Study Assessing Microdialysis as a Clinical Research Tool (submitted)
  • Jandial R, Duenas MJ, Chen MY. Neuroanatomy changes with repetitive mild head injury in athletes. Neurosurgery. 2013 Jun;72(6):N20. doi: 10.1227/01.neu.0000430739.63491.ba. No abstract available.PMID:23685515[PubMed - in process]
  • Jandial R, Kelly B, Chen MY. Posterior-only approach for lumbar vertebral column resection and expandable cage reconstruction for spinal metastases. J Neurosurgery Spine. 2013 Jul;19(1):27-33. doi: 10.3171/2013.4.SPINE12344. Epub 2013 May 17.PMID:23682809[PubMed - in process]
  • Rahul Jandial, Mike Chen. Heterogeneous Cellular Origins for Glioma in Murine Model. Neurosurgery 2013 Feb;72(4): N20
  • Rahul Jandial, M.D., Ph.D., Brandon Kelly, M.D., Mike Yue Chen, M.D., Ph.D. Nerve root sparing posterior approach for lumbar vertebral column resection and expandable cage reconstruction for spinal metastases (in press JNS spine)
  • Josh Neman, Vincent J Duenas, Claudia M Kowolik, Cecilia Choy, Sarah Waliany, Athena Anderson, Beth Chen, Michael Y Chen, Rahul Jandial. Co-evolution of breast to brain metastatic and neural progenitor cells. Clinical Experimental Cancer Metastasis (2013 Feb28 epub in press)
  • Marc B. Cabanne, Quang D. Ma, Rahul Jandial, MD, PhD, Javed Siddiqi, MD, PhD, Mike Y. Chen. Prevalence of Hepatitis B and C in Patients with Meningiomas and Glioblastoma Multiforme. Oncology Letters 2013 Mar;5(3):783-786. Epub 2013 Jan 10.
  • Rahul Jandial, Mike Chen. Modified Lateral Extracavitary Approach for Vertebral Column Resection and Expandable Cage Reconstruction of Thoracic Spinal Metastases. Surg Neurol Int. 2012;3:136.
  • Axial Spondylectomy and Circumferential Reconstruction via a Posterior Approach. Rahul Jandial, Brandon Kelly, Mike Chen. Neurosurgery. 2013 Feb;72(2):300-8
  • Mike Yue Chen, M.D., Ph.D., Rahul Jandial, M.D., Ph.D. Mini-open Transpedicular Lumbar Vertebrectomy Reconstructed with Double Cages and Short segment Fixation. Surgical Neurology International 2012 supplement 5(3):S362-5
  • Neman J., Duenas V J., Kowolik C., Hambrecht A., *Jandial R., *Chen M Y. Characterization of the Native Progenitor Population in Cellular Bone Allografts. * co-senior authors. Spine J. 2013 Feb;13(2):162-74
  • Zhaoxia Zou, Erin Denny, Christine Brown, Michael Jensen, Gang Li, Tatsuhiro Fujii, Josh Neman, Rahul Jandial, Mike Chen. Cytotoxic T Lymphocyte Trafficking and Survival in an Augmented Fibrin Matrix Carrier. PLoS ONE April 2012 7(4): e34652 .
  • Rahul Jandial, Lonnissa H. Nguyen, Mike Y. Chen. Surface topography can be used to instruct stem cell fate. Neurosurgery Feb 2012;70(2):N14-6.
  • Jandial, Rahul, Chen, Mike Y. Ciacci, Joseph. HIF-1α potentiates mesenchymal stem cell mediated osteogenesis by coupling to angiogenesis. Neurosurgery. October 2011;69(4) N13-N14
  • Rahul Jandial, Dawn J. Waters, Mike Y. Chen. Cancer stem cells can arise from differentiated neoplastic cells. Neurosurgery August 2011; 69(2): N22-N22
  • Mike Yue Chen, Aaron Clark, Dana Chan, Joy Ware, Shawn Holt, Archana Chidambaram, Helen Fillmore, William Broaddus. Wilms’ Tumor 1 Silencing Decreases the Viability and Chemoresistance of Glioblastoma cells in vitro: A potential role for IGF-1R de-repression. J. Neuro-oncology 2011 May;103:87-102.
  • Margarita Gutova, Joseph Najbauer, Mike Chen, Philip Potter, Seung Kim, Karen Aboody. Therapeutic targeting of melanoma cells using neural stem cells expressing carboxylesterase, a CPT-11 activating enzyme. Current Stem Cell Research & Therapy. 2010; 6, 273-276
  • Mike Chen, Rahul Jandial. Environmental cues for mesenchymal stem cell fate determination. Neurosurgery 2010;67(4) N20
  • Mike Chen, Rahul Jandial. The Practical Horizon for Robotic Neurosurgery. Neurosurgery 2009: 65(3) pN12
  • Jana Portnow, Behnam Badie, Mike Chen, An Liu, Suzette Blanchard, Timothy W. Synold. The Neuropharmacokinetics of Temozolomide in Patients with Resectable Brain Tumors: potential Implications for the current approach to chemoradiation. Clinical Cancer Research. 2009;15(22) 7092-8
  • Babak Kateb, M. A. Ryan, M. L. Homer, L. M. Lara, Yufang Yin, Kerin Higa, Mike Y. Chen. Sniffing Out Cancer Using the JPL Electronic Nose: A Novel Approach to Detection and Differentiation of Brain Cancer. Neuroimage 2009 Aug;47 Suppl 2:T5-9.
  • Aaron Clark, Joy L Ware, Mike Y Chen, Martin R. Graf, Timothy E Van Meter, Wagner G. DosSantos, Helen Fillmore, William C Broaddus. Effect of WT1 gene silencing on the tumorigenicity of human glioblastoma cells. Journal of Neurosurgery 2009(Apr 24)

Locations

City of Hope - Main Campus (Duarte)
1500 East Duarte Road
Duarte, CA 91010
 
City of Hope - South Pasadena
209 S. Fair Oaks Ave.
So. Pasadena, CA 91030

Media

Laboratory Members

   

Lab Research Associate: Amanda Nesbit

Amanda Nesbit recently graduated from CSUB with her Bachelor of Science in Chemistry, concentration in Biochemistry, and minor in Biology. At City of Hope, she is currently working on the use of Pulsed Electromagnetic Fields (PEMF) to increase the uptake of chemotherapy drugs.
   

Lab Research Intern: Philip Fedor
Philip Fedor is currently about to begin his Sophomore year at Creighton University in Omaha, Nebraska. He is a Biology major with a Pre- Med focus and plans on pursuing a career in Sports Medicine. In Dr. Chen’s lab, he is working with Amanda Nesbit to analyze the effects of Pulsed Electromagnetic Fields (PEMF) on cell growth when combined with chemotherapy drugs and when used independently.
   

Lab Research Associate: Jenny Lin

Jenny Lin recently graduated UCLA with a B.A. in English and is currently applying to medical school. At City of Hope, she is gathering patient data for a retrospective chart review to further understanding of the influence of breast cancer receptor status, i.e. HER2, estrogen and/or progesterone, on metastatic spinal lesions. Furthermore, she studies the pathological fractures and epidural disease rates with receptor status and examines if the type of bony lesions, either lytic or blastic, will be the same in the spine versus other parts of the skeleton.
 
Moreover, she is also working to generate data to test the hypothesis of whether lung to brain metastases are resistant due to Polycomb/histone epigenetic mediated changes, by using triptolide to target the WNT/Polycomb pathway. Histone methylation has emerged as the central epigenetic change in the organization of eukaryotic chromatin, which effects cell proliferation, gene expression and regulation. She will be performing enzyme assays of metastatic lung to brain tissues, to detect levels of histone methylation with and without triptolide.
   

Lab Research Intern: Alisha Jain
Alisha Jain is pursuing a Bachelor of Science in Human Biology from the University of California, San Diego. She has extensive experience working in Dr. Chen’s lab at City of Hope since high school, and is studying the role of various polycomb proteins and Polycomb genes in epigenetic events affecting glioblastoma in order to better understand the origins of the disease and develop effective preventive and therapeutic interventions.
 
She and Sean hypothesize that glioblastoma could employ an epithelial-to-mesenchymal transition (EMT)- like process to develop into a mesenchymal subtype and epigenetic factors playing a role in EMT in other tumor types could be candidate master regulators of mesenchymal differentiation and proliferation.
   

Lab Research Intern: Sean Dewberry
Sean Dewberry currently studies Molecular and Environmental Biology at UC Berkeley and will be starting sophomore year Fall 2014. In Dr. Chen's lab, he is working closely with Alisha Jain and under the guidance of Dr. Li and Dr. Wang. They are examining the role of polycomb proteins and their effect on glioblastomas. It is their hope to identify the origins of this type of tumor and develop possible treatments to combat it.