Contact Information
Leslie Bernstein, Ph.D.
  • Interim Chair, Department of Population Sciences
  • Director and Professor, Cancer Etiology

Research Areas
  • Dr. Bernstein’s research focuses primarily on breast cancer, seeking to identify modifiable lifestyle factors that will reduce incidence and extend survival. She has also pursued research investigating the long-term chronic disease outcomes of therapeutic regimens for breast cancer.
  • Dr. Bernstein leads the California Teachers Study, a prospective cohort of 133,479 female public school professionals formed in 1995 to study breast and other cancers. As the study’s principal investigator, she manages a broad collaboration of 17 investigators at four cancer centers.
  • Dr. Bernstein is an active participant in a number of national and international research collaborations and pooling projects for breast cancer, endometrial cancer, NHL and esophageal adenocarcinoma.

Professional Experience

  • 2014 - present, Interim Chair, Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA
  • 2007 - present, Professor and Director, Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA
  • 2007 - 2014, Dean for Faculty Affairs, City of Hope, Duarte, CA
  • 2007 - present, Professor Emeritus, Keck School of Medicine, University of Southern California (USC), Los Angeles, CA
  • 2006 - 2007, Chair, Department of Preventive Medicine Faculty Appointments, Promotions Committee
  • 2003 - 2007, Program Leader, Women’s Cancer Program, USC/Norris Comprehensive Cancer Center
  • 2003 - 2004, Vice Provost, Medical Affairs, USC, Los Angeles California
  • 1998 - 2007, AFLAC, Incorporated, Chair in Cancer Research
  • 1996 - 2003, Senior Associate Dean, Faculty Affairs, Keck School of Medicine USC, Los Angeles, CA
  • 1991 - 2007, Professor of Preventive Medicine, Keck School of Medicine USC, Los Angeles, CA
  • 1988 - 2007, Scientific Director, USC Cancer Surveillance Program (for Los Angeles County)
  • 1988 - 1991, Associate Professor of Preventive Medicine, USC School of Medicine, Los Angeles, CA
  • 1982 - 1988, Assistant Professor of Preventive Medicine, USC School of Medicine, Los Angeles, CA

Education

Education/Training
  • 1981, University of Southern California, Los Angeles, CA, Ph.D., Biometry
  • 1978, University of Southern California, Los Angeles, CA, M.S., Gerontology
  • 1965, University of California, Los Angeles, CA, B.A., Mathematics

Honors/Awards

Awards
  • 2010, Recipient, Abraham Lilienfeld Award for Lifetime Contributions to Epidemiology, American College of Epidemiology
  • 2010, Recipient, Rosalind E. Franklin Award, National Cancer Institute
  • 2007, Recipient, Brinker Award for Distinguished Achievement in Clinical Research, Komen For the Cure Foundation
  • 2007, AACR-Prevent Cancer Foundation Award for Excellence in Cancer Prevention Research
  • 2003, Recipient, American Society for Preventive Oncology Distinguished Achievement Award
  • 2001, Recipient, University of Southern California Elaine Stevely Hoffman Achievement Award
  • 2000, Recipient, University of Southern California Presidential Medallion

Honors
  • 2011, Named to Gallery of Medical and Scientific Achievement, City of Hope
  • 2010, Ruell A. Stallones Memorial Lecturer , University of Texas School of Public Health, Houston TX
  • 2006, Slone Memorial Lecture, Boston University
  • 2006, Meadow Brook Lecture, Southeast Michigan Center for Medical Education, Rochester, MI
  • 2005, Plenary Lecture, San Antonio Breast Cancer Symposium
  • 2005, Cutter Lectureship, Harvard School of Public Health, Boston, MA

Memberships

  • 2011 - present, Deputy Editor, Breast Cancer Research
  • 2011 - present, Chair, External Advisory Committee, Seattle Cancer Consortium Breast SPORE, Fred Hutchinson Cancer Research Center and University of Washington
  • 2011 - present, Member, Women in Cancer Research (WICR) Council, American Association for Cancer Research
  • 2009 - present, Member, External Advisory Committee, UT MD Anderson Comprehensive Cancer Center
  • 1995 - 2007, 2010 - 2012, Member, External Advisory Committee, University of Hawaii Cancer Research Center
  • 2009 - present, Member, Scientific Advisory Committee, Three Generation Breast Cancer Cohort
  • 2008 - present, Member, Scientific Advisory Board of the Susan G. Komen for the Cure Tissue Bank at the IU Simon Cancer Center
  • 2003 - present, Member, Editorial Board, Epidemiology (2003-2007); Obesity (2007-present)
  • 2003 - present, Chair, Scientific Advisory Board, Sisters Study, NIEHS
  • 2001 - present, Chair, Scientific Advisory Board, Texas Mexican-American Cohort Study, MD Anderson Cancer Center
  • 1997 - present, Member, Permanent Scientific Committee, O.E.S.O. (France),
  • 2004 - present, Member, Scientific Advisory Committee, Breakthrough Generations Breast Cancer Study (UK)
  • 2004 - present, Member, Scientific Advisory Committee, University of North Carolina, Center for Environmental Health and Susceptibility
  • 1994 - present, Chair, Advisory Committee, Nurse’s Health Study, Harvard University (1995-present)
  • 1994 - 1996, 2007-2010, President and Executive Committee for the Society for Epidemiologic Research
  • 1984 - present, Study Sections – at NIH, numerous ad hoc, four as permanent study section member
  • 2007 - 2008, Chair, Susan G. Komen for the Cure Breast Cancer Epidemiology Study Section
  • 2001 - 2006, Member, Board of Scientific Counselors, National Cancer Institute
  • 2000 - 2003, Member, Integration Panel, Department of Defense Breast Cancer Research Program

Publications

  • Ma H, Henderson KD, Sullivan-Halley J, Duan L, Marshall SF, Ursin G, Horn-Ross PL, Largent J, Deapen DM, Lacey JV Jr, Bernstein L. Pregnancy-related factors and the risk of breast carcinoma in situ and invasive breast cancer among postmenopausal women in the California Teachers Study cohort. Breast Cancer Res, 12, R35, 2010. PMC2917030.
  • Zell JA, Ziogas A, Bernstein L, Clarke CA, Deapen D, Largent JA, Neuhausen SL, Stram DO, Ursin G, Anton-Culver H. Meat consumption, non-steroidal anti-inflammatory drugs, and colorectal cancer mortality in the California Teachers Study. Cancer Prev Res, 3, 865-875, 2010. PMC2931369.
  • Canchola AJ, Chang ET, Bernstein L, Largent JA, Reynolds P, Deapen D, Ursin G, Horn-Ross PL. Body size and the risk of endometrial cancer by hormone therapy use in postmenopausal women in the California Teachers Study cohort. Cancer Cause Control. 21, 1407-1416, 2010. PMC2925506.
  • Largent JA, Bernstein L, Horn-Ross PL, Marshall SF, Neuhausen S, Reynolds P, Ursin G, Zell JA, Ziogas A, Anton-Culver H. Hypertension, antihypertensive medication use and breast cancer risk in the California Teachers Study cohort. Cancer Cause Control, 21, 1616-1624, 2010. PMC2941047.
  • Saxena T, Lee E, Henderson KD, Clarke CA, West D, Marshall SF, Deapen D, Bernstein L, Ursin G. Menopausal hormone therapy and subsequent risk of specific invasive breast cancer subtypes in the California Teachers Study. Cancer Epidemiol Biomarkers Prev, 19, 2366-2378, 2010 PMC2936672.
  • Canchola AJ, Chang ET, Bernstein L, Largent JA, Reynolds P, Deapen D, Ursin G, Horn-Ross PL. Body size and the risk of ovarian cancer by hormone therapy use in the California Teachers Study. Cancer Cause Control, 21, 2241-2248, 2010. PMC3120052.
  • Chang ET, Clarke CA, Canchola AJ, Lu Y, Wang SS, Ursin G, West DW, Bernstein L, Horn-Ross PL. Alcohol consumption over time and risk of lymphoid malignancies in the California Teachers Study cohort. Am J Epidemiol, 172, 1373-1383, 2010. PMC3105275.
  • Lu Y, Wang SS, Sullivan-Halley J, Chang ET, Clarke CA, Henderson KD, Ma H, Duan L, Lacey JV, Deapen D, Bernstein L. Oral contraceptives, menopausal hormone therapy use and risk of B-cell non-Hodgkin lymphoma in the California Teachers Study. Int J Cancer, 129, 974-982, 2011. PMC3258672.
  • Press DJ, Sullivan-Halley J, Ursin G, Deapen D, McDonald JA, Strom BL, Norman SA, Simon MS, Marchbanks PA, Folger SG, Liff JM, Burkman RT, Malone KE, Weiss LK, Spirtas R, Bernstein L. Breast cancer risk and ovariectomy, hysterectomy, and tubal sterilization in the Women’s Contraceptive and Reproductive Experiences Study. Am J Epidemiol, 173, 38–47, 2011. PMC3025644.
  • Irwin ML, Duggan C, Smith AW, McTiernan A, Baumgartner RN, Baumgartner KB, Bernstein L, Ballard-Barbash R. Fasting C-peptide levels and death resulting from all causes and breast cancer: The Health Eating Activity and Lifestyle Study. J Clin Oncol, 29, 47-53, 2011 PMC305585.
  • Stram DO, Liu Y, Henderson K, Sullivan-Halley J, Luo J, Saxena T, Reynolds P, Chang E, Neuhausen S, Horn-Ross P, Bernstein L, Ursin G. Age-specific effects of hormone therapy use on overall mortality and ischemic heart disease mortality among women in the California Teachers Study. Menopause, 18, 253-261, 2011. PMC3253313.
  • Dieli-Conwright CM, Sullivan-Halley J, Patel A, Press M, Malone K, Ursin G, Burkman R, Strom B, Simon M, Weiss L, Marchbanks P, Folger S, Spirtas R, Deapen D, Bernstein L. Does hormone therapy counter the beneficial effects of physical activity on breast cancer risk in postmenopausal women? Cancer Cause Control, 22, 237-249, 2011. PMC3229264.
  • Kruper L, Holt A, Xu XX, Duan L, Henderson K, Bernstein L, Ellenhorn J. Disparities in reconstruction rates after mastectomy: Patterns of care and factors associated with the use of breast reconstruction in Southern California. Ann Surg Oncol, 18, 2168-2165, 2011, PMID: 21308486.
  • Clague J, Reynolds P, Sullivan-Halley J, Ma H, Lacey Jr JV, Henderson KD, Ursin G, West D, Bernstein L. Menopausal hormone therapy does not influence lung cancer risk: Results from the California Teachers Study. Cancer Epidemiol Biomarkers Prev, 20,560-564, 2011. PMC3065239.
  • Bernstein L, Lacey JV. (Invited editorial) Receptors, associations, and risk-factor differences by breast cancer subtypes: Positive or Negative? J Natl Cancer Inst, 103, 451-453, 2011.
  • Shahabi A, Bernstein L, Azen SP, McClain AD, Belcher B, Hsu YW, Nguyen-Rodriguez ST, Spruijt-Metz D. Recruitment and retention of African-American and Latina pre-adolescent females into a longitudinal bio-behavioral study. Ethnicity & Health, 21, 91-98, 2011. PMID: 21462737.
  • Lee E, Schumacher F, Lewinger JP, Neuhausen SL, Anton-Culver H, Horn-Ross PL, Henderson KD, Van Den Berg D, Bernstein L, Ursin G. The association of polymorphisms in hormone metabolism pathway genes, menopausal hormone therapy, and breast cancer risk in the California Teachers Study. Breast Cancer Res, 13, R37, 2011. PMC3219200
  • Davis-Dao CA, Henderson KD, Sullivan-Halley J, Ma H, West D, Xiang YB, Gago-Dominguez M, Stern MC, Castelao E, Conti D, Pike MC, Bernstein L, Cortessis VK. Lower risk in parous women suggests hormonal factors important in bladder cancer etiology. Cancer Epidemiol Biomarkers Prev, 20, 1156-1170, 2011. PMC3312020.
  • Lu Y, Ma H, Malone KE, Norman SA, Sullivan-Halley J, Strom BL, Simon MS, Marchbanks PA, McDonald JA, West DW, Henderson KD, Deapen D, Ursin G, Bernstein L. Oral contraceptive use and survival in women with invasive breast cancer. Cancer Epidemiol Biomarkers Prev, 20, 1391-1397, 2011. PMC3132273.
  • Ma H, Carpenter CL, Sullivan-Halley J, Bernstein L. The roles of complementary and alternative medicine in survivorship and quality of life among long-term breast cancer survivors – results of a prospective study. BMC Cancer.11:222, 2011. PMC3126792.
  • Choudhury F, Bernstein L, Hodis HN, Stanczyk F, Mack WJ. Physical activity and sex hormone levels in estradiol and placebo-treated postmenopausal women. Menopause, 18, 1079-1086, 2011. PMC3183237.
  • Lipsett MJ, Ostro BD, Reynolds P, Goldberg D, Hertz A, Hurley S, Jerrett M, Smith DF, Garcia C, Chang ET, Bernstein L. Long-term exposure to air pollution and circulatory disease in the California Teachers Study cohort. Am J Respiratory Crit Care Med, 184, 828-835, 2011. PMC3208653.
  • Horn-Ross PL, Canchola AJ, Ma H, Reynolds P, Bernstein L. Hormonal factors and the risk of papillary thyroid cancer in the California Teachers Study cohort. Cancer Epidemiol Biomarkers Prev, 20, 1751-1759, 2011. PMC3288117.
  • Lu Y, Ma H, Malone KE, Norman SA, Sullivan-Halley J, Strom BL, Marchbanks PA, Spirtas R, Burkman RT, Deapen D, Folger SG, Simon MS, Press MF, McDonald JA, Bernstein L. Obesity and survival among Black women and White women with invasive breast cancer. J Clin Oncol, 29, 3358-3365, 2011. PMC3164241.
  • Lu Y, Wang SS, Reynold P, Ma H, Chang ET, Sullivan-Halley E, Clarke CA, Bernstein L. Cigarette smoking, lifetime exposure to passive smoking, and the risk of non-Hodgkin lymphoma in the California Teachers Study. Am J Epidemiol, 174, 563-573, 2011. PMC3202153.
  • Kruper L, Xu X, Henderson K, Bernstein L. Disparities in reconstruction rates after mastectomy for ductal carcinoma in situ (DCIS): Patterns of care and factors associated with the use of breast reconstruction for DCIS as compared with invasive cancer. Ann Surg Oncol, 18, 3210-3219, 2011. PMID:21863363.
  • Ma H, Sullivan-Halley J, Smith AW, Neuhouser ML, Alfano CM, Meeske K, George SM, McTiernan A, McKean-Cowdin R, Baumgartner KB, Ballard-Barbash R, Bernstein L. Estrogenic botanical supplements, health-related quality of life, fatigue, and hormone-related symptoms in breast cancer survivors: A HEAL Study report. BMC Complement Alternat Med, 11, 109 (8 November 2011): biomedcentral.com PMC3234199.
  • Lee E, McKean-Cowdin R, Ma H, Spicer DV, Van Den Berg D, Bernstein L, Ursin G. Characteristics of triple-negative breast cancer in patients with a BRCA1 mutation, results from a population-based study of young women. J Clin Oncol, 29, 4373-4380, 2011. PMC3221522.
  • Jiang X, Bernstein L, Wu AH. Diabetes and risk of esophageal and gastric adenocarcinoma. Int J Cancer. 2011 Dec 8. doi: 10.1002/ijc.27390. [Epub ahead of print]. PMC3340473.
  • Razavi P, Lee E, Bernstein L, Van Den Berg D, Horn-Ross PL, Ursin G. Variations in sex hormone metabolism genes, postmenopausal hormone therapy and risk of endometrial cancer. Int J Cancer, 130, 1629-1638, 2012. PMC3267886.
  • Duan L, Koebnick C, Lacey JV, Sullivan-Halley J, Templeman C, Marshall SF, Neuhausen SL, Ursin G, Bernstein L, Henderson KD. Bilateral oophorectomy is not associated with increased mortality risk. Fertil Steril, 97, 111-117, 2012. PMC3245786.
  • Brooks JD, John EM, Mellemkjær L, Reiner AS, Malone KE, Lynch CF, Figueiredo JC, Haile RW, Shore RE, The WECARE Study Collaborative Group, Bernstein JL, Bernstein L. Body Mass Index and Risk of Second Primary Breast Cancer: The WECARE Study. Breast Cancer Res Treat, 131, 571-580, 2012. PMC3251700.
  • Canchola AJ, Anton-Culver H, Bernstein L, Clarke CA, Henderson K, Ma H, Ursin G, Horn-Ross PL. Body size and the risk of postmenopausal breast cancer subtypes in the California Teachers Study cohort. Cancer Causes Control, 2012 Jan 28. [Epub ahead of print] PMC3366039.
  • Bernstein L. Breast cancer: Risk and mortality after oestrogen-alone therapy—is it safe? Nature Rev Clinical Oncol, 9:255-7, 2012 PMID: 22473098.
  • Jones ME, van Leeuwen FE, Hoogendoorn WE, Mourits MJE, Hollema H, van Boven H, Press MF, Bernstein L, Swerdlow AJ.Endometrial cancer survival after breast cancer in relation to tamoxifen treatment: pooled results from three countries. Breast Cancer Res, 2012 Jun 12;14(3):R91. [Epub ahead of print]. PMID: 22691381.

Locations

  • City of Hope - Main Campus (Duarte)
    1500 East Duarte Road
    Duarte, CA 91010