Contact Information
Behnam Badie, M.D., F.A.C.S.
  • Vice Chair, Surgery
  • Chief, Neurosurgery
  • Director, Brain Tumor Program
  • Professor of Surgery

Primary Specialties

Departments/Division/Program

Languages Spoken
  • Farsi

Biography


Neurosurgery chief, Behnam Badie, M.D., F.A.C.S., on transforming brain tumor treatment through research collaborations.
Behnam Badie, M.D., an expert in the field of surgical neuro-oncology, is the director of the Brain Tumor Program and the Division of Neurosurgery at the City of Hope National Medical Center. Dr. Badie has special interest in the treatment of skull base tumors, acoustic neuromas, pituitary tumors, meningiomas and other nervous system tumors. His clinical research is in the development of minimally invasive techniques for treatment of both benign and malignant brain tumor. Dr. Badie earned his medical degree and completed an internship and residency at the University of California Los Angeles.
 
Prior to joining the Department of Neurosurgery, Dr. Badie was an Associate Professor and vice-chair of the Department of Neurological Surgery at the University of Wisconsin in Madison where he also served as the director of the Comprehensive Brain Tumor Program. Dr. Badie’s research interests focus on brain tumor immunology. More specifically, his research team is attempting to develop novel immunotherapy approaches for malignant brain tumors through the activation of microglia and macrophages using nanoparticles. This research is currently funded by the NCI and other organizations. Dr. Badie has published more than 140 articles, book chapters and abstracts in peer-reviewed journal. He is an active member of the American Association of Neurological Surgeons, Congress of Neurological Surgeons, Society of Neuro-oncology, and others.

Professional Experience


  • July, 2011 – Present – Beckman Research institute Board of Directors Beckman Research Institute/City of Hope Medical Center, Duarte, CA
  • May 2011-present Vice Chair, Department of Surgery City of Hope Medical Center Duarte, CA
  • June, 2012- present- Chair, Faculty Senate Executive Committee Beckman Research Institute/City of Hope Medical Center, Duarte CA
  • 2005 - present, Professor, Chief, Division of Neurosurgery, City of Hope, Duarte, CA
  • August 2005-December 2009 Associate Professor, Chief Division of Neurosurgery, City of Hope Medical Center Duarte, CA
  • 2005 - present, Director, Brain Tumor Program, City of Hope, Duarte, CA
  • 2004 - 2005, Member, Cellular and Molecular Pathology Training Program, University of Wisconsin, Madison
  • 2003 - 2005, Vice-Chair, Academic Affairs, Department of Neurological Surgery, University of Wisconsin, Madison
  • 2002 - 2005, Associate Professor (Tenure), Department of Neurological Surgery, University of Wisconsin, Madison
  • 1996 - 2005, Member, University of Wisconsin Comprehensive Cancer Center, Immunology/Biological Therapy Program
  • 1996 – 2005, Member, University of Wisconsin Comprehensive Cancer Center, Immunology/Biological Therapy Program
  • 1996 - 2005, Director, Comprehensive Brain Tumor Program. University of Wisconsin, Madison
  • 1996 - 2002, Assistant Professor, Department of Neurological Surgery. University of Wisconsin, Madison

Education

 
Education/Training
  • 1990 - 1996, University of California Los Angeles, Division of Neurological Surgery, Resident
  • 1989 - 1990, University of California Los Angeles, Department of Surgery, Intern
  • 1985 - 1989, University of California School of Medicine, Los Angeles, CA, M.D.
  • 1980 - 1984, University of California Los Angeles. Division of Biochemistry, B.S.

Board Certifications/Licensure
  • 2000, Fellow, American College of Surgeons
  • 1998, American Board of Neurological Surgery
  • 1996, State of Wisconsin
  • 1990, State of California
 

Honors/Awards

 
Awards
 
  • 2012 Caltech-City of Hope Biomedical Initiative Award Recipient
  • 2011 City of Hope Excellence Award Winner
  • “Americas Top Doctors for Cancer” by Castle Connolly 2007- 2012
  • 2008, "Top Doctors for Cancer" by Castle Connolly
  • 2007, Courage and Dedication Crystal Award, International Brain Mapping and Intra-operative Surgical Planning Society (IBMISPS)
  • 2007, "Top Doctors for Cancer" by Castle Connolly
  • 2002, Departmental Teaching Award in Neurosurgery, University of Wisconsin
  • Alpha Omega Alpha Medical Society 1988
  • Howard Hughes Medical Student Research Grant Summer 1987

Honors

  • 2003 - 2004, Best Doctors in America. Alpha Omega Alpha Magna Cum Laude Departmental Honors in Biochemistry
  • 2002, Best abstract presentation, AANS/CNS Section on Tumors
  • 2002, Magna Cum Laude and Excellence in Design for education exhibit, The Radiological Society of North America
  • 2002, "Top Doctor" or "Best Doctor" by Castle Connolly and/or BestDoctors.com
  • 1986, Best abstract presentation, Medical Student Summer Research Program
  • Magna cum Laude 1984
  • UCLA Departmental Honors in Biochemistry 1984
 

Memberships


  • American Association for the Advancement of Science
  • American Association for Cancer Research
  • American Association of Neurological Surgeons (AANS)
  • American Society of Gene Therapy
  • Congress of Neurological Surgeons (CNS)Society of Neuro-oncology
  • International Society for Biological Therapy of Cancer
  • North American Skull Base Society
  • Western Neurosurgical Society

Publications


  • Kim DH, Schultheiss TE, Radany EH, Badie B, Pezner RD Clinical outcomes of patients treated with a second course of stereotactic radiosurgery for locally or regionally recurrent brain metastases after prior stereotactic radiosurgery.J Neurooncol. 2013 Jun 28. [Epub ahead of print]PMID:23813230[PubMed - as supplied by publisher]
  • Carvalho da Fonseca AC, Badie B. Microglia and macrophages in malignant gliomas: recent discoveries and implications for promising therapies. Clin Dev Immunol. 2013;2013:264124. doi: 10.1155/2013/264124. Epub 2013 Jun 25.PMID:23864876[PubMed - in process
  • Portnow J, Badie B, Liu X, Frankel P, Mi S, Chen M, Synold TW. Changes in Intracerebral Cytokine Levels after Craniotomy and In Response to Treatment with Temsirolimus in Patients with Brain Tumors: A Pilot Study Assessing Microdialysis as a Clinical Research Tool. (Submitted)
  • Aboody KS, Najbauer J, Metz MZ, D’Apuzzo M, Gutova M, Annala AJ, Synold TW, Couture LA, Blanchard S, Moats RA, Garcia E, Aramburo S, Valenzuela VV, Frank RT, Barish ME, Kim SU, Badie B, Portnow J. Neural Stem Cell-Mediated Enzyme-Prodrug Therapy for High-Grade Glioma: From the Bench to Approval for a First-in-Human Clinical Trial. Science Translational Medicine. Clin Cancer Res. 2013 Jun 19.
  • Wang H, Zhang L, Zhang I, Fan H, Chen X, Da Fonseca A, Badie S, Sadeghi S, Badie B. S100B Promotes Glioma Growth through Chemoattraction of Myeloid-Derived Macrophages. Clin Cancer Res. 2013 Jun 19.
  • Portnow J, Badie B, Markel S, Liu A, D’Apuzzo M, Frankel P, Jandial R, Synold TW. A Neuropharmacokinetic Assessment of Bafetinib, a Second Generation Dual BCR-ABL/Lyn Tyrosine Kinase Inhibitor, in Patients with Recurrent High-Grade Gliomas. Eur J Cancer. 2013 May;49(7):1634-40. doi: 10.1016/j.ejca.2013.01.001. Epub 2013 Feb 4.
  • Badie B, Berlin JM. The future of CpG immunotherapy in cancer. Immunotherapy. 2013 Jan;5(1):1-3. doi: 10.2217/imt.12.148
  • Kushchayev SV, Kushchayeva YS, Wiener PC, Badie B, Preul MC. Monocyte-Derived Cells of the Brain and Malignant Gliomas: The Double Face of Janus. World Neurosurg. 2012 Nov 23. doi:pii: S1878-8750(12)01358-7. 10.1016/j.wneu.2012.11.059.
  • Fan H, Zhang I, Chen X, Zhang L, Wang H, Da Fonseca A, Manuel ER, Diamond D, Raubatcheck A, and Badie B. Intracerebral CpG Immunotherapy with Carbon Nanotubes Abrogates Growth of Subcutaneous Melanomas in Mice. Clinical Cancer Research. Clin Cancer Res. 2012 Oct 15;18(20):5628-38. doi: 10.1158/1078-0432.CCR-12-1911. Epub 2012 Aug 17
  • Zhao D, Alizadeh D, Zhang L, Liu W, Farrukh O, Manuel E, Diamond DJ, Badie B. Carbon Nanotubes Enhance CpG Uptake and Potentiate Anti-Glioma Immunity. Clin Cancer Res. 17:771-782, 2011.
  • Zhang L, Liu W, Alizadeh D, Zhao D, Farrukh O, Lin J, Badie SA, Badie B. S100B attenuates microglia activation in gliomas: Possible role of STAT3 pathway. Glia, 59(3): 486-98, 2011.
  • Zhang L, Alizadeh D, Badie B. Carbon nanotube uptake and toxicity in the brain. Methods Mol Biol 625:55-65, 2010.
  • Kateb B, Yamamoto V, Alizadeh D, Zhang L, Manohara HM, Bronikowski MJ, Badie B. Multi-walled carbon nanotube (MWCNT) synthesis, preparation, labeling, and functionalization. Methods Mol Biol 651:307-17, 2010.
  • Alizadeh D, Zhang L, Hwang J, Schluep T, Badie B. Tumor-associated macrophages are predominant carriers of cyclodextrin-based nanoparticles into gliomas. Nanomedicine 6:382-90, 2010.
  • Alizadeh D, Zhang L, Brown CE, Farrukh O, Jensen MC, Badie B. Induction of anti-glioma natural killer cell response following multiple low-dose intracerebral CpG therapy. Clin Cancer Res 16:3399-408, 2010.
  • Zhang L, Alizadeh D, Van Handel M, Kortylewski M, Yu H, Badie B. Stat3 inhibition activates tumor macrophages and abrogates glioma growth in mice. Glia 57:1458-67, 2009.
  • Portnow J, Badie B, Chen M, Liu A, Blanchard S, Synold TW. The neuropharmacokinetics of temozolomide in patients with resectable brain tumors: potential implications for the current approach to chemoradiation. Clin Cancer Res 15:7092-8, 2009.
  • Van Handel M, Alizadeh D, Zhang L, Kateb B, Bronikowski M, Monahara H, Badie B, Selective Uptake of Multi-Walled Carbon Nanotubes by Tumor Macrophages in a Murine Glioma Model. Journal of Neuroimmunology, 208, 3-9. 2009
  • Brown CE, Starr R, Martinez C, Aguilar B, D'Apuzzo M, Todorov I, Shih CC, Badie B, Hudecek M, Riddell SR and others. 2009. Recognition and killing of brain tumor stem-like initiating cells by CD8+ cytolytic T cells. Cancer Res 69:8886-93.
  • Do, L., Pezner, R., Radany, E., Liu, A., Staud, C., and Badie, B. Resection followed by stereotactic radiosurgery to resection cavity for intracranial metastases. Int J Radiat Oncol Biol Phys 73, 486-91,2009
  • Pub Med

Patents


  • Bayonet Sucker Forceps (Patent number: 5,250,075); manufactured by Scanlan International, St. Paul, Minnesota, USA)
  • Surgical Devices and Related Methods Thereof (U.S. Serial No. 12/638,619; filed: Dec. 15, 2009)
  • Immunotherapy of Brian Tumors Using a Carbon Nanotube CpG Delivery System (provisional patent filed Nov. 2011)

Locations

City of Hope - Main Campus (Duarte)
1500 East Duarte Road
Duarte, CA 91010
 
City of Hope - South Pasadena
209 S. Fair Oaks Ave.
So. Pasadena, CA 91030
 
 

Media

 
Video

Books/Book Chapters
  • Kateb B, Yamamoto V, Alizadeh D, Zhang L, Manohara HM, Bronikowski MJ, Badie B.. Multi-walled Carbon Nanotube(MWCNT) Synthesis, Preparation, Labeling, And Functionalization. Immunotherapy of Cancer: Methods in Molecular Biology. Vol. 651:307-17, 2010
  • Zhang L, Alizadeh D, Badie B, Carbon Nanotube Uptake and Toxicity in the Brain, Methods in Molecular Biology Methods and Protocols Series: Vol. 625 2009
  • Moritz CH, Rowley, HR, Badie B, Wendt GJ, Haughton VM. Practical clinical applications of fMRI. In Clinical MRI (3rd ed.) edited by Edelman, Hesselink, and Zlatkin. New York: Elsevier (in press).
  • Masciopinto JE, Badie B, and Dempsey RJ. In: Neurosurgery: The Scientific Basis of Clinical Practice, Third Edition, vol 2. “Ultrasonography of the Nervous System.” Blackwell Science Ltd., publ, Crockard A, Hayward R, and Hoff J, eds, pp. 817-827, 2000.
  • B. Badie Books
 
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