A National Cancer Institute-designated Comprehensive Cancer Center

Make an appointment: 800-826-HOPE
Nuclear Magnetic Resonance Core Bookmark and Share

Nuclear Magnetic Resonance Core

The main focus of the facility is to apply high resolution Nuclear Magnetic Resonance (NMR) spectroscopy to structural characterization of biomolecules, small organic compounds and natural products; to investigate interactions between biomolecules, biomolecules and ligands, to do the NMR-based metabolomics and fragment-based drug screening etc.
 
The facility has commercial software such as Discover Studio, Chenomx as well as some free software for biomolecular characterization and metabolomics studies.
 

Abstract

The Nuclear Magnetic Resonance (NMR) Core is located in the Hilton Building, Room 123. The main focus of this core is to apply high resolution NMR spectroscopy to the structural characterization of biomolecules, small organic compounds, natural products; investigation of biomolecular complexes including protein-protein, protein-nucleic acid and protein-ligand complexes; identification of metabolites in biofluids; and fragment-based drug screening.
 

The Nuclear Magnetic Resonance Core has one Bruker 600 MHz Avance NMR instrument that is equipped with four channels, a TXI cryo-probe and a room temperature probe, and one Bruker 700 MHz Ascend equipped with TCI cryoprobe and a sample jet can handle up to 480 NMR tubes for batch screening study. Both instruments are operated with HP workstations running the Linux operating system, have pulse shaping capability on three channels (1H/13C/15N), and 2H decoupling capability.
 

Pricing

Prices and availability vary. Please Contact Us or login to the core  iLab site for current information.
 
To schedule instrument time or set up a consultation please visit the core iLab Site
 

Services and Equipment

Services
 
  1. Understand the mechanism of actions of proteins and nucleic acids at atomic details through the characterization of structures and interaction of the biomolecules
  2. Analysis of protein-ligand interactions and fragment-based drug screening
  3. Structure elucidation of natural products and synthetic compounds
  4. Metabolomics
 
Equipment
 
600 MHz Bruker Avance NMR Instrument
Bruker 600 MHz Avance equipped with a TXI cryoprobe and a sample case holds up to 24 samples.
   
700 MHz NMR Instrument
Bruker 700 MHz Ascend equipped with TCI cryoprobe and a sample jet can handle up to 480 NMR tubes for batch screening study.

 
Both instruments are operated with HP workstations running the Linux operating system, have pulse shaping capability on three channels (1H/13C/15N), and 2H decoupling capability.
 
NMR Core also hosts an Isothermal titration calorimeter.

Nuclear Magnetic Resonance Team

Nuclear Magnetic Resonance Core

Nuclear Magnetic Resonance Core

The main focus of the facility is to apply high resolution Nuclear Magnetic Resonance (NMR) spectroscopy to structural characterization of biomolecules, small organic compounds and natural products; to investigate interactions between biomolecules, biomolecules and ligands, to do the NMR-based metabolomics and fragment-based drug screening etc.
 
The facility has commercial software such as Discover Studio, Chenomx as well as some free software for biomolecular characterization and metabolomics studies.
 

Abstract

Abstract

The Nuclear Magnetic Resonance (NMR) Core is located in the Hilton Building, Room 123. The main focus of this core is to apply high resolution NMR spectroscopy to the structural characterization of biomolecules, small organic compounds, natural products; investigation of biomolecular complexes including protein-protein, protein-nucleic acid and protein-ligand complexes; identification of metabolites in biofluids; and fragment-based drug screening.
 

The Nuclear Magnetic Resonance Core has one Bruker 600 MHz Avance NMR instrument that is equipped with four channels, a TXI cryo-probe and a room temperature probe, and one Bruker 700 MHz Ascend equipped with TCI cryoprobe and a sample jet can handle up to 480 NMR tubes for batch screening study. Both instruments are operated with HP workstations running the Linux operating system, have pulse shaping capability on three channels (1H/13C/15N), and 2H decoupling capability.
 

Pricing

Pricing

Prices and availability vary. Please Contact Us or login to the core  iLab site for current information.
 
To schedule instrument time or set up a consultation please visit the core iLab Site
 

Services and Equipment

Services and Equipment

Services
 
  1. Understand the mechanism of actions of proteins and nucleic acids at atomic details through the characterization of structures and interaction of the biomolecules
  2. Analysis of protein-ligand interactions and fragment-based drug screening
  3. Structure elucidation of natural products and synthetic compounds
  4. Metabolomics
 
Equipment
 
600 MHz Bruker Avance NMR Instrument
Bruker 600 MHz Avance equipped with a TXI cryoprobe and a sample case holds up to 24 samples.
   
700 MHz NMR Instrument
Bruker 700 MHz Ascend equipped with TCI cryoprobe and a sample jet can handle up to 480 NMR tubes for batch screening study.

 
Both instruments are operated with HP workstations running the Linux operating system, have pulse shaping capability on three channels (1H/13C/15N), and 2H decoupling capability.
 
NMR Core also hosts an Isothermal titration calorimeter.

Team

Nuclear Magnetic Resonance Team

Research Shared Services

City of Hope embodies the spirit of scientific collaboration by sharing services and core facilities with colleagues here and around the world.
 

Recognized nationwide for its innovative biomedical research, City of Hope's Beckman Research Institute is home to some of the most tenacious and creative minds in science.
City of Hope is one of only 41 Comprehensive Cancer Centers in the country, the highest designation awarded by the National Cancer Institute to institutions that lead the way in cancer research, treatment, prevention and professional education.
Learn more about City of Hope's institutional distinctions, breakthrough innovations and collaborations.
Support Our Research
By giving to City of Hope, you support breakthrough discoveries in laboratory research that translate into lifesaving treatments for patients with cancer and other serious diseases.
 
 
 
 
Media Inquiries/Social Media

For media inquiries contact:

Dominique Grignetti
800-888-5323
dgrignetti@coh.org

 

For sponsorships inquiries please contact:

Stefanie Sprester
213-241-7160
ssprester@coh.org

Christine Nassr
213-241-7112
cnassr@coh.org

 
CONNECT WITH US
Facebook  Twitter  YouTube  Blog
 
NEWS & UPDATES
  • Rob Darakjian was diagnosed with acute lymphoblastic leukemia at just 19 years old. He began chemotherapy and was in and out of the hospital for four months. After his fourth round of treatment, he received a bone marrow transplantation from an anonymous donor. Today, he’s cancer free. In his first post, ...
  • Advanced age tops the list among breast cancer risk factor for women. Not far behind is family history and genetics. Two City of Hope researchers delving deep into these issues recently received important grants to advance their studies. Arti Hurria, M.D., director of the Cancer and Aging Research Program, and ...
  • City of Hope is extending the reach of its lifesaving mission well beyond U.S. borders. To that end, three distinguished City of Hope leaders visited China earlier this year to lay the foundation for the institution’s new International Medicine Program. The program is part of City of Hope’s strategi...
  • A hallmark of cancer is that it doesn’t always limit itself to a primary location. It spreads. Breast cancer and lung cancer in particular are prone to spread, or metastasize, to the brain. Often the brain metastasis isn’t discovered until years after the initial diagnosis, just when patients were beginning to ...
  • Blueberries, cinnamon, baikal scullcap, grape seed extract (and grape skin extract), mushrooms, barberry, pomegranates … all contain compounds with the potential to treat, or prevent, cancer. Scientists at City of Hope have found tantalizing evidence of this potential and are determined to explore it to t...
  • Most women who are treated for breast cancer with a mastectomy do not choose to undergo reconstructive surgery. The reasons for this, according to a recent JAMA Surgery study, vary. Nearly half say they do not want any additional surgery, while nearly 34 percent say breast cancer reconstruction simply isn’t imp...
  • The leading risk factor for breast cancer is simply being a woman. The second top risk factor is getting older. Obviously, these two factors cannot be controlled, which is why all women should be aware of their risk and how to minimize those risks. Many risk factors can be mitigated, and simple changes can lead...
  • All women are at some risk of developing the disease in their lifetimes, but breast cancer, like other cancers, has a disproportionate effect on minorities. Although white women have the highest incidence of breast cancer, African-American women have the highest breast cancer death rates of all racial and ethni...
  • First, the good news: HIV infections have dropped dramatically over the past 30 years. Doctors, researchers and health officials have made great strides in preventing and treating the disease, turning what was once a death sentence into, for some, a chronic condition. Now, the reality check: HIV is still a worl...
  • Screening for breast cancer has dramatically increased the number of cancers found before they cause symptoms – catching the disease when it is most treatable and curable. Mammograms, however, are not infallible. It’s important to conduct self-exams, and know the signs and symptoms that should be checked by a h...
  • Rob Darakjian was diagnosed with acute lymphoblastic leukemia at just 19 years old. He began chemotherapy and was in and out of the hospital for four months. After his fourth round of treatment, he received a bone marrow transplantation from an anonymous donor. Today, he’s cancer free.   In his previ...
  • In a single day, former professional triathlete Lisa Birk learned she couldn’t have children and that she had breast cancer. “Where do you go from there?” she asks. For Birk, who swims three miles, runs 10 miles and cycles every day, the answer  ultimately was a decision to take control of her cancer care. Afte...
  • More and more people are surviving cancer, thanks to advanced cancer treatments and screening tools. Today there are nearly 14.5 million cancer survivors in the United States. But in up to 20 percent of cancer patients, the disease ultimately spreads to their brain. Each year, nearly 170,000 new cases of brain ...
  • Cancer cells are masters of survival. Despite excessive damage to their most basic workings and the constant vigilance of the body’s immune system, they manage to persevere. Much of this extraordinary ability to survive falls under the control of proteins bearing the name STAT, short for signal transducer and a...
  • One person receives the breast cancer diagnosis, but the cancer affects the entire family. Couples, in particular, can find the diagnosis and treatment challenging, especially if they have traditional male/female communication styles. “Though every individual is unique, men and women often respond differently d...