A National Cancer Institute-designated Comprehensive Cancer Center

Make an appointment: 800-826-HOPE
Nuclear Magnetic Resonance Core Bookmark and Share

Nuclear Magnetic Resonance Core

The main focus of the facility is to apply high resolution Nuclear Magnetic Resonance (NMR) spectroscopy to structural characterization of biomolecules, small organic compounds and natural products; to investigate interactions between biomolecules, biomolecules and ligands, to do the NMR-based metabolomics and fragment-based drug screening etc.
 
The facility has commercial software such as Discover Studio, Chenomx as well as some free software for biomolecular characterization and metabolomics studies.
 

Abstract

The Nuclear Magnetic Resonance (NMR) Core is located in the Hilton Building, Room 123. The main focus of this core is to apply high resolution NMR spectroscopy to the structural characterization of biomolecules, small organic compounds, natural products; investigation of biomolecular complexes including protein-protein, protein-nucleic acid and protein-ligand complexes; identification of metabolites in biofluids; and fragment-based drug screening.
 

The Nuclear Magnetic Resonance Core has one Bruker 600 MHz Avance NMR instrument that is equipped with four channels, a TXI cryo-probe and a room temperature probe, and one Bruker 700 MHz Ascend equipped with TCI cryoprobe and a sample jet can handle up to 480 NMR tubes for batch screening study. Both instruments are operated with HP workstations running the Linux operating system, have pulse shaping capability on three channels (1H/13C/15N), and 2H decoupling capability.
 

Pricing

Prices and availability vary. Please Contact Us or login to the core  iLab site for current information.
 
To schedule instrument time or set up a consultation please visit the core iLab Site
 

Services and Equipment

Services
 
  1. Understand the mechanism of actions of proteins and nucleic acids at atomic details through the characterization of structures and interaction of the biomolecules
  2. Analysis of protein-ligand interactions and fragment-based drug screening
  3. Structure elucidation of natural products and synthetic compounds
  4. Metabolomics
 
Equipment
 
600 MHz Bruker Avance NMR Instrument
Bruker 600 MHz Avance equipped with a TXI cryoprobe and a sample case holds up to 24 samples.
   
700 MHz NMR Instrument
Bruker 700 MHz Ascend equipped with TCI cryoprobe and a sample jet can handle up to 480 NMR tubes for batch screening study.

 
Both instruments are operated with HP workstations running the Linux operating system, have pulse shaping capability on three channels (1H/13C/15N), and 2H decoupling capability.
 
NMR Core also hosts an Isothermal titration calorimeter.

Nuclear Magnetic Resonance Team

Nuclear Magnetic Resonance Core

Nuclear Magnetic Resonance Core

The main focus of the facility is to apply high resolution Nuclear Magnetic Resonance (NMR) spectroscopy to structural characterization of biomolecules, small organic compounds and natural products; to investigate interactions between biomolecules, biomolecules and ligands, to do the NMR-based metabolomics and fragment-based drug screening etc.
 
The facility has commercial software such as Discover Studio, Chenomx as well as some free software for biomolecular characterization and metabolomics studies.
 

Abstract

Abstract

The Nuclear Magnetic Resonance (NMR) Core is located in the Hilton Building, Room 123. The main focus of this core is to apply high resolution NMR spectroscopy to the structural characterization of biomolecules, small organic compounds, natural products; investigation of biomolecular complexes including protein-protein, protein-nucleic acid and protein-ligand complexes; identification of metabolites in biofluids; and fragment-based drug screening.
 

The Nuclear Magnetic Resonance Core has one Bruker 600 MHz Avance NMR instrument that is equipped with four channels, a TXI cryo-probe and a room temperature probe, and one Bruker 700 MHz Ascend equipped with TCI cryoprobe and a sample jet can handle up to 480 NMR tubes for batch screening study. Both instruments are operated with HP workstations running the Linux operating system, have pulse shaping capability on three channels (1H/13C/15N), and 2H decoupling capability.
 

Pricing

Pricing

Prices and availability vary. Please Contact Us or login to the core  iLab site for current information.
 
To schedule instrument time or set up a consultation please visit the core iLab Site
 

Services and Equipment

Services and Equipment

Services
 
  1. Understand the mechanism of actions of proteins and nucleic acids at atomic details through the characterization of structures and interaction of the biomolecules
  2. Analysis of protein-ligand interactions and fragment-based drug screening
  3. Structure elucidation of natural products and synthetic compounds
  4. Metabolomics
 
Equipment
 
600 MHz Bruker Avance NMR Instrument
Bruker 600 MHz Avance equipped with a TXI cryoprobe and a sample case holds up to 24 samples.
   
700 MHz NMR Instrument
Bruker 700 MHz Ascend equipped with TCI cryoprobe and a sample jet can handle up to 480 NMR tubes for batch screening study.

 
Both instruments are operated with HP workstations running the Linux operating system, have pulse shaping capability on three channels (1H/13C/15N), and 2H decoupling capability.
 
NMR Core also hosts an Isothermal titration calorimeter.

Team

Nuclear Magnetic Resonance Team

Research Shared Services

City of Hope embodies the spirit of scientific collaboration by sharing services and core facilities with colleagues here and around the world.
 

Recognized nationwide for its innovative biomedical research, City of Hope's Beckman Research Institute is home to some of the most tenacious and creative minds in science.
City of Hope is one of only 41 Comprehensive Cancer Centers in the country, the highest designation awarded by the National Cancer Institute to institutions that lead the way in cancer research, treatment, prevention and professional education.
Learn more about City of Hope's institutional distinctions, breakthrough innovations and collaborations.
Support Our Research
By giving to City of Hope, you support breakthrough discoveries in laboratory research that translate into lifesaving treatments for patients with cancer and other serious diseases.
 
 
 
 
Media Inquiries/Social Media
 
CONNECT WITH US
Facebook  Twitter  YouTube  Blog
 


NEWS & UPDATES
  • When Keith McKinny, 29, was first diagnosed with lymphoma and leukemia in 2010, the first person he thought of was former boyfriend Jason Mullins. The two hadn’t been in contact with each other for some time, but McKinny couldn’t think of anyone else with whom he wanted to be during that difficult period....
  • Yesenia Portillo’s search for a bone marrow donor started close to home. Her brother, sister and seven cousins all underwent testing, but none of them were a close enough match to donate the bone marrow stem cells she desperately needed for her transplant. Yesenia, now 16, had always been healthy and active. Bu...
  • Some of City of Hope’s most high-impact achievements have arisen from City of Hope’s globally recognized bone marrow transplant (BMT) program. The annual Karl G. Blume – Gerhard Schmidt Memorial Lecture in Transplantation Biology & Medicine — commemorating two of the most influential and revered...
  • Guido Marcucci, M.D., wants to put himself out of business. A respected clinician and esteemed basic and translational scientist, Marcucci joins City of Hope as co-director of the Gehr Family Center for Leukemia Research within the Hematologic Malignancies and Stem Cell Transplantation Institute. In this positi...
  • To say that myelofibrosis patients need more treatment options would be an understatement. The severely low platelet counts, known as thrombocytopenia, that are one of the hallmark symptoms of the disease can lead to chronic fatigue and weakness that not only damage quality of life but, ultimately, shorten life...
  • Patients with metastatic colorectal cancer often stop responding to the primary drugs used against the disease, leaving them with few options and little hope. Determined to increase those options, doctors and researchers at City of Hope are conducting two clinical trials that could lead to new treatments for pe...
  • Investigators working at City of Hope are making many significant inroads against many forms of cancer. To do that, they have to take a variety of approaches. Molecular oncology researchers focus on abnormal cancer-associated activity in a cell’s nucleus. One especially prominent factor in many breast and ovari...
  • In light of the new breast cancer screening guidelines, which call for women to have mammograms every other year from age 50 to 74, it’s more important than ever for women to understand their individual risk. On Monday, the U.S. Preventive Services Task force released new breast cancer screening guideline...
  • Cancer patients need, and deserve, more than medical care. They and their families need high-quality supportive care – that is, care that addresses their physical, emotional and spiritual well-being. Health care professionals increasingly understand this, but starting such programs from scratch isn’t easy...
  • Each year, City of Hope patients given another chance at life gather to pose for a picture like this one. Going on its 39th year, the celebration of patients free of blood cancers thanks to bone marrow or stem cell transplants has grown such that a photographer has to scale a cherry picker just to […]
  • Cancer patients who are participating in early-stage clinical trials need extra emotional and physical support due to their additional stress and often unique symptoms. Now an effort by researchers at City of Hope to create a model for such support has received a $6.8 million grant from the National Cancer Inst...
  • The need for improvements in treating malignant brain tumors has never been greater. Survival for many patients with these tumors are sometimes measured in just months. One reason that therapeutic options are limited is that traditional surgery is deemed too risky for many brain tumors, especially for those in ...
  • “Honestly, there’s nothing special about my story,” protested Daniel Samson, as he bounced Layla, his 3 1/2-year-old daughter, on his lap and put on a video for her to watch. “I just want to tell it for my own sake, and share it with other men who may be going through this chaos.” Samson spoke […]
  • As far back as he can remember, Jonathan Yamzon, M.D., wanted to be a doctor. “I knew it from the get-go,” he said, matter-of-factly. “I always envisioned it as the ideal; the supreme thing one could do with one’s life.” The youngest of six children, Yamzon was barely a toddler when his family moved to [&...
  • There’s never a “good” time for cancer to strike. With testicular cancer, the timing can seem particularly unfair. This disease targets young adults in the prime of life; otherwise healthy people unaccustomed to any serious illness, let alone cancer. And suddenly … “I can only imagine what they must...