What does cell signaling have to do with kidney disease in diabetics?
By Darrin S. Joy
Cells govern their internal processes through highly complex signaling systems. A recent City of Hope study published in the journal Science Signaling shed more light on how cells control this system — and how diabetes can cause a malfunction that leads to kidney disease.
Traffic signals abound to keep cells’ inner workings flowing smoothly. When the signals become muddled, illness such as diabetic kidney disease can arise.
The study’s senior author, Rama Natarajan, Ph.D., director of the Division of Molecular Diabetes Research at City of Hope, explained the science published in their paper, “TGF-β Induces Acetylation of Chromatin and of Ets-1 to Alleviate Repression of miR-192 in Diabetic Nephropathy.”
What’s the main finding of this study?
MicroRNAs (miRNAs) are recently discovered small, noncoding RNAs that have been shown to affect the expression of genes and play pivotal roles in physiological and pathological processes. However, the mechanisms by which miRNAs are regulated are not fully understood.