A National Cancer Institute-designated Comprehensive Cancer Center

Make an appointment: 800-826-HOPE
Research Bookmark and Share

Lung Cancer Research

There is extensive collaboration between lung cancer clinicians and researchers develop and evaluate new therapies designed to improve survival and quality of life outcomes. City of Hope patients have access to a wide variety of clinical trials ranging from new chemotherapy and targeted therapies, hormone therapies, novel surgical techniques and new radiation approaches — all focused on enhancing lung cancer treatment, detection and prevention.
 
Some of our current research projects include:
 
  • Our researchers are currently studying markers of metastatic potential within lymph nodes of patients with completely resected non-small cell lung cancer (NSCLC). This allows them to better understand how the tumor and the immune system interact to facilitate cancer spread. By understanding these mechanisms, targeted molecules can then be developed to block tumor metastasis and improve survival.
  • As we gain knowledge into the biology of lung cancer, our clinicians have also incorporated the evaluation of biomarkers into our trials to better tailor therapies to our patients, particularly those with advanced disease.
  • The signaling pathway cyclooxygenase-2 (COX-2) plays a key role in lung tumor growth, spread and therapy resistance, so our researchers developed a drug trial to see if the COX-2 inhibitor, celecoxib, can improve outcomes by enhancing the effectiveness of another lung cancer drug.
  • Patients with advanced lung cancer frequently have immune system abnormalities, including depletion of the B cells and T cells, which make up the body’s defense system. Our researchers have identified a compound in shiitake mushrooms called beta-glucans that can enhance immune system activity, and City of Hope is conducting a trial to see if it can slow or halt tumor growth in lung cancer patients.
  • Because lung cancer patients are often present with advanced disease that compromises their quality of life, City of Hope researchers are continually investigating and implementing interventions that can support patients and their families through supportive and palliative care.
 
 
If you have been diagnosed with lung cancer or are looking for a second opinion consultation about your treatment, find out more about becoming a patient or contact us at 800-826-HOPE.
 
 
 
 

Research

Lung Cancer Research

There is extensive collaboration between lung cancer clinicians and researchers develop and evaluate new therapies designed to improve survival and quality of life outcomes. City of Hope patients have access to a wide variety of clinical trials ranging from new chemotherapy and targeted therapies, hormone therapies, novel surgical techniques and new radiation approaches — all focused on enhancing lung cancer treatment, detection and prevention.
 
Some of our current research projects include:
 
  • Our researchers are currently studying markers of metastatic potential within lymph nodes of patients with completely resected non-small cell lung cancer (NSCLC). This allows them to better understand how the tumor and the immune system interact to facilitate cancer spread. By understanding these mechanisms, targeted molecules can then be developed to block tumor metastasis and improve survival.
  • As we gain knowledge into the biology of lung cancer, our clinicians have also incorporated the evaluation of biomarkers into our trials to better tailor therapies to our patients, particularly those with advanced disease.
  • The signaling pathway cyclooxygenase-2 (COX-2) plays a key role in lung tumor growth, spread and therapy resistance, so our researchers developed a drug trial to see if the COX-2 inhibitor, celecoxib, can improve outcomes by enhancing the effectiveness of another lung cancer drug.
  • Patients with advanced lung cancer frequently have immune system abnormalities, including depletion of the B cells and T cells, which make up the body’s defense system. Our researchers have identified a compound in shiitake mushrooms called beta-glucans that can enhance immune system activity, and City of Hope is conducting a trial to see if it can slow or halt tumor growth in lung cancer patients.
  • Because lung cancer patients are often present with advanced disease that compromises their quality of life, City of Hope researchers are continually investigating and implementing interventions that can support patients and their families through supportive and palliative care.
 
 
If you have been diagnosed with lung cancer or are looking for a second opinion consultation about your treatment, find out more about becoming a patient or contact us at 800-826-HOPE.
 
 
 
 
Quick Links
About the Lung Cancer Program


Karen Reckamp, M.D., M.S., co-director of the Lung Cancer and Thoracic Oncology Program, discusses lung cancer treatment and research at City of Hope.
What’s in cigarette smoke?
Did you know that there are more than 7,000 chemicals in tobacco smoke? Hundreds are toxic and at least 70 are known to cause cancer.
 
 
Lung Cancer Videos
 
Vicky Graham, a lung cancer survivor, shares her experience about City of Hope's palliative care services for lung cancer patients. Watch Vicky's story »
 
Learn more about City of Hope's lung cancer treatments and research by watching the Lung Cancer YouTube playlist »
 
Medical Minute
 
 
 


NEWS & UPDATES
  • To say that myelofibrosis patients need more treatment options would be an understatement. The severely low platelet counts, known as thrombocytopenia, that are one of the hallmark symptoms of the disease can lead to chronic fatigue and weakness that not only damage quality of life but, ultimately, shorten life...
  • Patients with metastatic colorectal cancer often stop responding to the primary drugs used against the disease, leaving them with few options and little hope. Determined to increase those options, doctors and researchers at City of Hope are conducting two clinical trials that could lead to new treatments for pe...
  • Investigators working at City of Hope are making many significant inroads against many forms of cancer. To do that, they have to take a variety of approaches. Molecular oncology researchers focus on abnormal cancer-associated activity in a cell’s nucleus. One especially prominent factor in many breast and ovari...
  • In light of the new breast cancer screening guidelines, which call for women to have mammograms every other year from age 50 to 74, it’s more important than ever for women to understand their individual risk. On Monday, the U.S. Preventive Services Task force released new breast cancer screening guideline...
  • Cancer patients need, and deserve, more than medical care. They and their families need high-quality supportive care – that is, care that addresses their physical, emotional and spiritual well-being. Health care professionals increasingly understand this, but starting such programs from scratch isn’t easy...
  • Each year, City of Hope patients given another chance at life gather to pose for a picture like this one. Going on its 39th year, the celebration of patients free of blood cancers thanks to bone marrow or stem cell transplants has grown such that a photographer has to scale a cherry picker just to […]
  • Cancer patients who are participating in early-stage clinical trials need extra emotional and physical support due to their additional stress and often unique symptoms. Now an effort by researchers at City of Hope to create a model for such support has received a $6.8 million grant from the National Cancer Inst...
  • The need for improvements in treating malignant brain tumors has never been greater. Survival for many patients with these tumors are sometimes measured in just months. One reason that therapeutic options are limited is that traditional surgery is deemed too risky for many brain tumors, especially for those in ...
  • “Honestly, there’s nothing special about my story,” protested Daniel Samson, as he bounced Layla, his 3 1/2-year-old daughter, on his lap and put on a video for her to watch. “I just want to tell it for my own sake, and share it with other men who may be going through this chaos.” Samson spoke […]
  • As far back as he can remember, Jonathan Yamzon, M.D., wanted to be a doctor. “I knew it from the get-go,” he said, matter-of-factly. “I always envisioned it as the ideal; the supreme thing one could do with one’s life.” The youngest of six children, Yamzon was barely a toddler when his family moved to [&...
  • There’s never a “good” time for cancer to strike. With testicular cancer, the timing can seem particularly unfair. This disease targets young adults in the prime of life; otherwise healthy people unaccustomed to any serious illness, let alone cancer. And suddenly … “I can only imagine what they must...
  • Sure, a healthy lifestyle can lower a person’s risk, but the impact of specific actions is harder to tease out. Diet, exercise, tobacco use, nutritional supplements, alcohol consumption … How important are each of these factors, individually? Does strict adherence to (or rejection of) one get you a pass o...
  • Health care decisions are tough. They’re even tougher when you – or loved ones – have to make them without a plan or a conversation. National Healthcare Decisions Day, on April 16,  is a nationwide initiative to demystify the health care decision-making process and encourage families to start talking. Ult...
  • The statistics, direct from the American Cancer Society, are sobering: Cancer death rates among African-American men are 27 percent higher than for white men. The death rate for African-American women is 11 percent higher compared to white women. Hispanics have higher rates of cervical, liver and stomach cancer...
  • “Lucky” is not usually a term used to describe someone diagnosed with cancer.  But that’s how 34-year-old Alex Camargo’s doctor described him when he was diagnosed with thyroid cancer — the disease is one of the most treatable cancers at all stages. That doctor was ultimately proved righ...