What is "locoregional" therapy?
Minimally-invasive, intravascular, catheter-based therapies at targeting the individual blood vessels that directly supply tumor, using localized high-dose chemotherapy, blood-supply constricting embolic particles, and/or radioactive particles. There are many forms of locoregional, transcatheter-based therapies, with newer, increasingly effective treatment devices and regimens being developed. These therapies are considered “bridging therapy”, but are also at times employed as definitive treatment in certain situations.
Chemoembolization (TACE, Precision-TACE)
Chemoembolization is a form of locoregional therapy that specifically targets tumors by simultaneously delivering high dose local cancer killing agents, while also, blocking the blood vessels that supply the tumor (embolization). The end effect is higher local doses of the tumoricidal agent, without the typical side-effects of traditional systemic chemotherapy. Additionally, by closing the blood vessels that supply the tumor, cancer cells that may survive the chemotherapy starve resulting in eventually tumor regression.
Internal radiation therapy is another form of locoregional therapy that utilizes targeted delivery of small, radioactive particles into certain liver tumors, resulting in death of the rapidly dividing tumor cells, while preserving the relatively sturdy normal liver cells.
What are some common areas of treatment?
Currently, locoregional therapy is primarily being used in the setting of liver cancers, both primary and metastatic tumors.
What happens after the procedure?
Patients will continue to follow-up with their referring physician, as well as, the performing interventionalist post-procedure. During routine clinic visits, blood tumor markers and other surveillance imaging will be reviewed, based upon standard protocol.