A National Cancer Institute-designated Comprehensive Cancer Center

Make an appointment: 800-826-HOPE
Information Sciences Bookmark and Share

Department of Information Sciences

The Departmentof Information Sciences (DIS), consisting of the Divisions of Biostatistics, Research Informatics, and Clinical Research Information Support collaborates in numerous facets of both clinical and basic science research throughout the Medical Center and Beckman Research Institute, including study design, data quality and training,and computational statistical analysis.
 
Major activities include collaborations in clinical, laboratory, and epidemiological research; development of statistical methodologies; and teaching in the Irell & Manella Graduate School of Biological Sciences of City of Hope and in the Clinical Investigation Training Program (CITP) ; development of innovative information systems for research. The faculty members within the department participate as co-investigators on City of Hope grants, in addition to conducting their own research.
 
Our Vision
To convert raw data into information leading to new knowledge, to help speed biomedical discoveries, disease prevention, and therapeutic interventions.
 
Our Mission
To contribute to City of Hope’s mission and strategic plan through the development and application of research information science methods and technologies, by:
 
  • Supporting information management, integration, and synthesis across the translational research pipeline
  • Collaborating in the design, computerization, analysis and reporting of basic, translational, clinical, and population research
  • Facilitating the collection and delivery of accurate, complete electronic data for disease registries
  • Ensuring high quality results by applying best practices and international standards
     
Division of Biostatistics
The Division of Biostatistics houses faculty and staff statisticians. Their major activities include: collaboration in basic, translational and clinical research; consulting on statistical questions in research; development of statistical methodology, teaching in the Irell & Manella Graduate School of Biological Sciences and in the Clinical Investigation Training Program. The division operates the Cancer Center’s  Biostatistics Core , and supports coordinating centers for the National Comprehensive Cancer Network, The NCRR Islet Cell Resource Centers and the California Cancer Consortium.

Division of Clinical Research Information Support
The Division of Clinical Research Information Support (CRIS) provides expertise in training and continuing education of clinical research staff, data quality assurance, data collection for observational databases, quality assurance, multi-center coordination for treatment and observational protocols, data collection for disease registries and transplant procedures at City of Hope, cancer registry, data entry, and Clinical Trials OnlineSM(CTOL). The Division operates the protocol data management component of the Cancer Center’sClinical Protocol & Data Management Core (CPDMC).
 
Division of Research Informatics
The Division of Research Informatics (RI) includes systems analysts, application developers/software engineers, database administrators/architects, Electronic Data Capture/TeleForms group, and decision support services. The staff within RI is specially trained to focus on the information systems requirements unique to the research domain. RI combines the administrative and clinical care data collected during the normal course of patient care with protocol-specific data collected for research purposes and makes it available for use in outcome assessment and analysis. The Division also operates the clinical research informatics component of the Cancer Center’sClinical Protocol & Data Management Core (CPDMC).
 
Through the Biostatistics and Clinical Protocol & Data Management Cores, DIS faculty and staff follow NCI guidelines to provide support to Cancer Center members and City of Hope investigators.
 

Research Emphasis

 
The Division of Biostatistics provides statistical expertise for basic, translational, and clinical research in the Cancer Center. The services provided by the Division of Biostatistics are collaboration, consulting, and statistical computing. The core faculty members maintain expertise in a variety of specialized areas including clinical trials, high throughput functional genomics, pharmacokinetic modeling, epidemiology and statistical genetics. The Division of Biostatistics assists Cancer Center and Beckman Research Institute investigators with study design, analytic plan development, database design and data extraction, efficacy and safety monitoring, manuscript preparation, and the development of grant proposals and clinical protocols. Service to the institution includes statistical review of cancer-related clinical research protocols for the CPRMC, IRB and DSMB. Outside of their core activities, the faculty members are also engaged in externally funded biomedical research, the development of statistical methodology and teaching in the graduate school and the Clinical Investigation Training Program.
 
The Biostatistics Core is directed by Dr. Jeffrey Longmate, Director of the Division of Biostatistics, with Dr. David D. Smith serving as Co-Director. The Biostatistics Core draws effort from a large part of the Division of Biostatistics, with the Biostatistics Core enabling their participation in Cancer Center-related pilot projects and proposals, which may later develop into externally funded projects. The Biostatistics Core is directly involved in Cancer Center research from the inception of a research idea to the publication of results. Clinical research projects account for the largest portion of core use, but the Biostatistics Core also supports basic and translational research, as well as assisting several other cores. The Biostatistics Core staff collaborate closely with the Biomedical Informatics core to support data processing and analysis of gene expression microarrays, and the Biostatistics Core works closely with both the Clinical Research Informatics Core and the Clinical Trials Management Core to implement COH-conducted or coordinated clinical protocols. In addition to these ongoing collaborative efforts, there have been more technically-focused projects in which the Biostatistics Core has supported the other cores in the implementation of technologies that involve statistical measurement issues. This has recently included the Affymetrix Core, the Clinical Immunobiology Correlative Studies Lab, and the Genotyping Core.
 
  • Joyce Niland’s research interests are clinical trials methodology, outcomes research, and biomedical informatics. She also directs the Data Coordinating Centers for two nationwide research networks: (1) the National Comprehensive Cancer Network (NCCN) Outcomes Research Study, studying patterns of care, guideline concordance, and factors associated with patient outcomes within our nation’s Cancer Centers; and (2) the Islet Cell Resources (ICR) consortium, investigating optimization of islet cell harvesting for transplantation in type I diabetes.
 
  • Jeffrey Longmate’s research interests are study design and statistical inference arising from collaborations in genetics, immunology, and early-phase clinical trials. Dr. Longmate co-directs the coordinating center for multi-center Phase I/II drug development, directs the Data Coordinating Center for the Southern California Islet-Cell Consortium, and coordinates the Biostatistics segment of the Biostatistics and Bioinformatics course for the Graduate School and the Medical Fellows Training Program.
 
  • Li Cheng’s research interests include the role of genetic markers and receptors in the etiology and manifestation of disease processes.
 
  • David Smith is interested in pre-clinical study design, clinical trial methodology, and microarray study design and data analysis.
 
  • Paul Frankel’s research interests include clinical trials methodology and survival analysis techniques.
 
  • Rebecca Nelson’s research interests include exploring patterns of disease risk and outcomes as related to clinical and environmental covariates.
 
  • Dajun Qian’s research interests include clinical trial methodology, linkage analysis, and haplotype sharing correlation analysis.
 

Information Sciences Faculty and Staff

Information Sciences

Department of Information Sciences

The Departmentof Information Sciences (DIS), consisting of the Divisions of Biostatistics, Research Informatics, and Clinical Research Information Support collaborates in numerous facets of both clinical and basic science research throughout the Medical Center and Beckman Research Institute, including study design, data quality and training,and computational statistical analysis.
 
Major activities include collaborations in clinical, laboratory, and epidemiological research; development of statistical methodologies; and teaching in the Irell & Manella Graduate School of Biological Sciences of City of Hope and in the Clinical Investigation Training Program (CITP) ; development of innovative information systems for research. The faculty members within the department participate as co-investigators on City of Hope grants, in addition to conducting their own research.
 
Our Vision
To convert raw data into information leading to new knowledge, to help speed biomedical discoveries, disease prevention, and therapeutic interventions.
 
Our Mission
To contribute to City of Hope’s mission and strategic plan through the development and application of research information science methods and technologies, by:
 
  • Supporting information management, integration, and synthesis across the translational research pipeline
  • Collaborating in the design, computerization, analysis and reporting of basic, translational, clinical, and population research
  • Facilitating the collection and delivery of accurate, complete electronic data for disease registries
  • Ensuring high quality results by applying best practices and international standards
     
Division of Biostatistics
The Division of Biostatistics houses faculty and staff statisticians. Their major activities include: collaboration in basic, translational and clinical research; consulting on statistical questions in research; development of statistical methodology, teaching in the Irell & Manella Graduate School of Biological Sciences and in the Clinical Investigation Training Program. The division operates the Cancer Center’s  Biostatistics Core , and supports coordinating centers for the National Comprehensive Cancer Network, The NCRR Islet Cell Resource Centers and the California Cancer Consortium.

Division of Clinical Research Information Support
The Division of Clinical Research Information Support (CRIS) provides expertise in training and continuing education of clinical research staff, data quality assurance, data collection for observational databases, quality assurance, multi-center coordination for treatment and observational protocols, data collection for disease registries and transplant procedures at City of Hope, cancer registry, data entry, and Clinical Trials OnlineSM(CTOL). The Division operates the protocol data management component of the Cancer Center’sClinical Protocol & Data Management Core (CPDMC).
 
Division of Research Informatics
The Division of Research Informatics (RI) includes systems analysts, application developers/software engineers, database administrators/architects, Electronic Data Capture/TeleForms group, and decision support services. The staff within RI is specially trained to focus on the information systems requirements unique to the research domain. RI combines the administrative and clinical care data collected during the normal course of patient care with protocol-specific data collected for research purposes and makes it available for use in outcome assessment and analysis. The Division also operates the clinical research informatics component of the Cancer Center’sClinical Protocol & Data Management Core (CPDMC).
 
Through the Biostatistics and Clinical Protocol & Data Management Cores, DIS faculty and staff follow NCI guidelines to provide support to Cancer Center members and City of Hope investigators.
 

Research Emphasis

Research Emphasis

 
The Division of Biostatistics provides statistical expertise for basic, translational, and clinical research in the Cancer Center. The services provided by the Division of Biostatistics are collaboration, consulting, and statistical computing. The core faculty members maintain expertise in a variety of specialized areas including clinical trials, high throughput functional genomics, pharmacokinetic modeling, epidemiology and statistical genetics. The Division of Biostatistics assists Cancer Center and Beckman Research Institute investigators with study design, analytic plan development, database design and data extraction, efficacy and safety monitoring, manuscript preparation, and the development of grant proposals and clinical protocols. Service to the institution includes statistical review of cancer-related clinical research protocols for the CPRMC, IRB and DSMB. Outside of their core activities, the faculty members are also engaged in externally funded biomedical research, the development of statistical methodology and teaching in the graduate school and the Clinical Investigation Training Program.
 
The Biostatistics Core is directed by Dr. Jeffrey Longmate, Director of the Division of Biostatistics, with Dr. David D. Smith serving as Co-Director. The Biostatistics Core draws effort from a large part of the Division of Biostatistics, with the Biostatistics Core enabling their participation in Cancer Center-related pilot projects and proposals, which may later develop into externally funded projects. The Biostatistics Core is directly involved in Cancer Center research from the inception of a research idea to the publication of results. Clinical research projects account for the largest portion of core use, but the Biostatistics Core also supports basic and translational research, as well as assisting several other cores. The Biostatistics Core staff collaborate closely with the Biomedical Informatics core to support data processing and analysis of gene expression microarrays, and the Biostatistics Core works closely with both the Clinical Research Informatics Core and the Clinical Trials Management Core to implement COH-conducted or coordinated clinical protocols. In addition to these ongoing collaborative efforts, there have been more technically-focused projects in which the Biostatistics Core has supported the other cores in the implementation of technologies that involve statistical measurement issues. This has recently included the Affymetrix Core, the Clinical Immunobiology Correlative Studies Lab, and the Genotyping Core.
 
  • Joyce Niland’s research interests are clinical trials methodology, outcomes research, and biomedical informatics. She also directs the Data Coordinating Centers for two nationwide research networks: (1) the National Comprehensive Cancer Network (NCCN) Outcomes Research Study, studying patterns of care, guideline concordance, and factors associated with patient outcomes within our nation’s Cancer Centers; and (2) the Islet Cell Resources (ICR) consortium, investigating optimization of islet cell harvesting for transplantation in type I diabetes.
 
  • Jeffrey Longmate’s research interests are study design and statistical inference arising from collaborations in genetics, immunology, and early-phase clinical trials. Dr. Longmate co-directs the coordinating center for multi-center Phase I/II drug development, directs the Data Coordinating Center for the Southern California Islet-Cell Consortium, and coordinates the Biostatistics segment of the Biostatistics and Bioinformatics course for the Graduate School and the Medical Fellows Training Program.
 
  • Li Cheng’s research interests include the role of genetic markers and receptors in the etiology and manifestation of disease processes.
 
  • David Smith is interested in pre-clinical study design, clinical trial methodology, and microarray study design and data analysis.
 
  • Paul Frankel’s research interests include clinical trials methodology and survival analysis techniques.
 
  • Rebecca Nelson’s research interests include exploring patterns of disease risk and outcomes as related to clinical and environmental covariates.
 
  • Dajun Qian’s research interests include clinical trial methodology, linkage analysis, and haplotype sharing correlation analysis.
 

Information Sciences Faculty and Staff

Information Sciences Faculty and Staff

Research Shared Services

City of Hope embodies the spirit of scientific collaboration by sharing services and core facilities with colleagues here and around the world.
 

Recognized nationwide for its innovative biomedical research, City of Hope's Beckman Research Institute is home to some of the most tenacious and creative minds in science.
City of Hope is one of only 41 Comprehensive Cancer Centers in the country, the highest designation awarded by the National Cancer Institute to institutions that lead the way in cancer research, treatment, prevention and professional education.
Learn more about City of Hope's institutional distinctions, breakthrough innovations and collaborations.
Support Our Research
By giving to City of Hope, you support breakthrough discoveries in laboratory research that translate into lifesaving treatments for patients with cancer and other serious diseases.
 
 
 
 
Media Inquiries/Social Media

For media inquiries contact:

Dominique Grignetti
800-888-5323
dgrignetti@coh.org

 

For sponsorships inquiries please contact:

Stefanie Sprester
213-241-7160
ssprester@coh.org

Christine Nassr
213-241-7112
cnassr@coh.org

 
CONNECT WITH US
Facebook  Twitter  YouTube  Blog
 
NEWS & UPDATES
  • Jonathan Yamzon, M.D., assistant professor of surgery in the Division of Urology and Urologic Oncology, explains his approach to what’s known as “active surveillance” of men with prostate cancer.  Patients need to be educated about their treatment options, he writes. Active surveillance eligib...
  • For most prostate cancer patients, surgery or radiation therapy is the initial and primary treatment against the disease. But some patients can benefit from chemotherapy and hormone therapy too, especially if there are signs of a relapse or if the cancer has spread beyond the prostate gland. Here, Cy Stein, M.D...
  • Cancer research has yielded scientific breakthroughs that offer patients more options, more hope for survival and a higher quality of life than ever before. The 14.5 million cancer patients living in the United States are living proof that cancer research saves lives. Now, in addition to the clinic, hospital an...
  • Advances in cancer treatment, built on discoveries made in the laboratory then brought to the bedside, have phenomenally changed the reality of living with a cancer diagnosis. More than any other time in history, people diagnosed with cancer are more likely to survive and to enjoy a high quality of life. Howeve...
  • While health care reform has led to an increase in the number of people signing up for health insurance, many people remain uninsured or are not taking full advantage of the health benefits they now have. Still others are finding that, although their premiums are affordable, they aren’t able to see the do...
  • Kidney cancer rates and thyroid cancer rates in adults have continued to rise year after year. Now a new study has found that incidence rates for these cancers are also increasing in children — particularly in African-American children. The study, published online this month in Pediatrics, examined childhood ca...
  • Thyroid cancer has become one of the fastest-growing cancers in the United States for both men and women. The chance of being diagnosed with the cancer has nearly doubled since 1990. This year an estimated 63,000 people will be diagnosed with thyroid cancer in the United States and nearly 1,900 people will die ...
  • Older teenagers and young adults traditionally face worse outcomes than younger children when diagnosed with brain cancer and other central nervous system tumors. A first-of-its-kind study shows why. A team of researchers from the departments of Population Sciences and Pathology at City of Hope recently examine...
  • Cancer treatment can take a toll on the mouth, even if a patient’s cancer has nothing to do with the head or throat, leading to a dry mouth, or a very sore mouth, and making it difficult to swallow or eat. Here’s some advice from the National Cancer Institute (NCI)  on how to ease cancer-related dis...
  • Radiation oncology is one of the three main specialties involved in the successful treatment of cancer, along with surgical oncology and medical oncology. Experts in this field, known as radiation oncologists, advise patients as to whether radiation therapy will be useful for their cancer – and how it can best ...
  • There’s more to cancer care than simply helping patients survive. There’s more to cancer treatment than simple survival. Constant pain should not be part of conquering cancer,  insists Betty Ferrell, Ph.D., R.N., director of nursing research and education at City of Hope. She wants patients and caregivers...
  • Even its name is daunting. Systemic mastocytosis is a fatal disease of the blood with no known cure. But a new study suggests a bone marrow transplant may be the answer for some patients. While rare, systemic mastocytosis is resistant to treatment with drugs and, when aggressive, can be fatal within four years ...
  • Could what you eat affect the health of your chromosomes? The short answer is, “Yes.” Researchers led by Dustin Schones, Ph.D., assistant professor in the Department of Cancer Biology, and Rama Natarajan, Ph.D., director of the Division of Molecular Diabetes Research and the National Business Products Industry ...
  • September is Prostate Cancer Awareness Month. Here, Bertram Yuh, M.D., assistant clinical professor in the Division of Urology and Urologic Oncology at City of Hope, explains the importance of understanding the risk factors for the disease and ways to reduce those risks, as well as overall prostate health. “Wha...
  • ** Learn more about prostate health, plus prostate cancer research and treatment, at City of Hope. ** Learn more about getting a second opinion at City of Hope by visiting us online or by calling 800-826-HOPE (4673). City of Hope staff will explain what’s required for a consult at City of Hope and help yo...