A National Cancer Institute-designated Comprehensive Cancer Center

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Information Sciences

Department of Information Sciences
The Departmentof Information Sciences (DIS), consisting of the Divisions of Biostatistics, Research Informatics, and Clinical Research Information Support collaborates in numerous facets of both clinical and basic science research throughout the Medical Center and Beckman Research Institute, including study design, data quality and training,and computational statistical analysis.
Major activities include collaborations in clinical, laboratory, and epidemiological research; development of statistical methodologies; and teaching in the Irell & Manella Graduate School of Biological Sciences of City of Hope and in the Clinical Investigation Training Program (CITP) ; development ofinnovative information systems for research.The faculty members within the department participate as co-investigators on City of Hope grants, in addition to conducting their own research.
Our Vision
To convert raw data into information leading to new knowledge, to help speed biomedical discoveries, disease prevention, and therapeutic interventions.
Our Mission
To contribute to City of Hope’s mission and strategic plan through the development and application of research information science methods and technologies, by:
  • Supporting information management, integration, and synthesis across the translational research pipeline
  • Collaborating in the design, computerization, analysis and reporting of basic, translational, clinical, and population research
  • Facilitating the collection and delivery of accurate, complete electronic data for disease registries
  • Ensuring high quality results by applying best practices and international standards
Division of Biostatistics
The Division of Biostatistics houses faculty and staff statisticians. Their major activities include: collaboration in basic, translational and clinical research; consulting on statistical questions in research; development of statistical methodology, teaching in the Irell & Manella Graduate School of Biological Sciences and in the Clinical Investigation Training Program. The division operates the Cancer Center’s  Biostatistics Core , and supports coordinating centers for the National Comprehensive Cancer Network, The NCRR Islet Cell Resource Centers and the California Cancer Consortium.

Division of Clinical Research Information Support
The Division of Clinical Research Information Support (CRIS) provides expertise in training and continuing education of clinical research staff, data quality assurance, data collection for observational databases, quality assurance, multi-center coordination for treatment and observational protocols, data collection for disease registries and transplant procedures at City of Hope, cancer registry, data entry, and Clinical Trials OnlineSM(CTOL). The Division operates the protocol data managment component of the Cancer Center’sClinical Protocol & Data Management Core (CPDMC).
Division of Research Informatics
The Division of Research Informatics (RI) includes systems analysts, application developers/software engineers, database administrators/architects, Electronic Data Capture/TeleForms group, and decision support services. The staff within RI is specially trained to focus on the information systems requirements unique to the research domain. RI combines the administrative and clinical care data collected during the normal course of patient care with protocol-specific data collected for research purposes and makes it available for use in outcome assessment and analysis. The Division also operates the clinical research informatics component of the Cancer Center’sClinical Protocol & Data Management Core (CPDMC).
Through the Biostatistics and Clinical Protocol & Data Management Cores, DIS faculty and staff follow NCI guidelines to provide support to Cancer Center members and City of Hope investigators.

Research Emphasis

The Division of Biostatistics provides statistical expertise for basic, translational, and clinical research in the Cancer Center. The services provided by the Division of Biostatistics are collaboration, consulting, and statistical computing. The core faculty members maintain expertise in a variety of specialized areas including clinical trials, high throughput functional genomics, pharmacokinetic modeling, epidemiology and statistical genetics. The Division of Biostatistics assists Cancer Center and Beckman Research Institute investigators with study design, analytic plan development, database design and data extraction, efficacy and safety monitoring, manuscript preparation, and the development of grant proposals and clinical protocols. Service to the institution includes statistical review of cancer-related clinical research protocols for the CPRMC, IRB and DSMB. Outside of their core activities, the faculty members are also engaged in externally funded biomedical research, the development of statistical methodology and teaching in the graduate school and the Clinical Investigation Training Program.
The Biostatistics Core is directed by Dr. Jeffrey Longmate, Director of the Division of Biostatistics, with Dr. David D. Smith serving as Co-Director. The Biostatistics Core draws effort from a large part of the Division of Biostatistics, with the Biostatistics Core enabling their participation in Cancer Center-related pilot projects and proposals, which may later develop into externally funded projects. The Biostatistics Core is directly involved in Cancer Center research from the inception of a research idea to the publication of results. Clinical research projects account for the largest portion of core use, but the Biostatistics Core also supports basic and translational research, as well as assisting several other cores. The Biostatistics Core staff collaborate closely with the Biomedical Informatics core to support data processing and analysis of gene expression microarrays, and the Biostatistics Core works closely with both the Clinical Research Informatics Core and the Clinical Trials Management Core to implement COH-conducted or coordinated clinical protocols. In addition to these ongoing collaborative efforts, there have been more technically-focused projects in which the Biostatistics Core has supported the other cores in the implementation of technologies that involve statistical measurement issues. This has recently included the Affymetrix Core, the Clinical Immunobiology Correlative Studies Lab, and the Genotyping Core.
  • Joyce Niland’s research interests are clinical trials methodology, outcomes research, and biomedical informatics. She also directs the Data Coordinating Centers for two nationwide research networks: (1) the National Comprehensive Cancer Network (NCCN) Outcomes Research Study, studying patterns of care, guideline concordance, and factors associated with patient outcomes within our nation’s Cancer Centers; and (2) the Islet Cell Resources (ICR) consortium, investigating optimization of islet cell harvesting for transplantation in type I diabetes.
  • Jeffrey Longmate’s research interests are study design and statistical inference arising from collaborations in genetics, immunology, and early-phase clinical trials. Dr. Longmate co-directs the coordinating center for multi-center Phase I/II drug development, directs the Data Coordinating Center for the Southern California Islet-Cell Consortium, and coordinates the Biostatistics segment of the Biostatistics and Bioinformatics course for the Graduate School and the Medical Fellows Training Program.
  • Li Cheng’s research interests include the role of genetic markers and receptors in the etiology and manifestation of disease processes.
  • David Smith is interested in pre-clinical study design, clinical trial methodology, and microarray study design and data analysis.
  • Paul Frankel’s research interests include clinical trials methodology and survival analysis techniques.
  • Rebecca Nelson’s research interests include exploring patterns of disease risk and outcomes as related to clinical and environmental covariates.
  • Dajun Qian’s research interests include clinical trial methodology, linkage analysis, and haplotype sharing correlation analysis.

Information Sciences Faculty and Staff

Research Shared Services

City of Hope embodies the spirit of scientific collaboration by sharing services and core facilities with colleagues here and around the world.

Recognized nationwide for its innovative biomedical research, City of Hope's Beckman Research Institute is home to some of the most tenacious and creative minds in science.
City of Hope is one of only 41 Comprehensive Cancer Centers in the country, the highest designation awarded by the National Cancer Institute to institutions that lead the way in cancer research, treatment, prevention and professional education.
Learn more about City of Hope's institutional distinctions, breakthrough innovations and collaborations.
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