A National Cancer Institute-designated Comprehensive Cancer Center

Make an appointment: 800-826-HOPE
Immunology Bookmark and Share

Immunology

City of Hope’s Department of Immunology, one ofeight major basic science (“Laboratory Research”) departments of the Beckman Research Institute, was established in 1972 by Charles Todd. At that time, immune-based therapies were used on a very limited basis in cancer treatment, reserved for conditions such as malignant melanoma and bladder cancer. Most immunotherapy treatments consisted of agents such as BCG and interferon.

In recent years, the field of cancer immunology has grown by leaps and bounds, and a wide range of neoplastic diseases, including both hematologic malignancies and solid tumors,are routinely being treated with a well-stocked armamentarium of monoclonal antibodies and other immunotherapy methods.

The Department of Immunology continues its original vision, with a dual focus on both immunology and structural biology. It has seven principal investigators with research interests in cell and tumor immunology and structure analysis, who are aided by state-of-the-art facilities in mass spectrometry and NMR, as well as a computer cluster for computational chemistry.

The unique combination of biological and structural studies and the intensive exploration of structure-function relationships have created a thriving, productive environment that has encouraged fruitful collaboration among investigators at City of Hope and at other institutions.
 
Laboratory Research

John Shively, Ph.D. -  CEA (carcinoembryonic antigen) gene family
Dr. Shively's lab specializes in the CEA (carcinoembryonic antigen) gene family. In particular, he is researching the use of anti-CEA antibodies for tumor imaging and therapy and the role of CEACAM1 in T-cell activation and mammary epithelial cell polarization.  He is also exploring the relationship of the immune system and genetics to fibromyalgia.
 
Terry Lee, Ph.D. - Optimizing the application of biomolecule mass spectrometry
Dr. Lee’s focus is optimizing the application of biomolecule mass spectrometry to “real-world” biological problems. He develops new methods for proteomic analyses by mass spectrometry including integrated microfluidic systems for sample preparation and automated methods of data acquisition and analysis.
 
Markus Kalkum, Ph.D. - Develops novel biochemical and mass spectrometric methods
Dr. Kalkum develops novel biochemical and mass spectrometric methods for the sensitive detection of functional biomolecules in complex samples. His goal is to improve the early diagnosis of emerging and frequently under-diagnosed diseases, including opportunistic fungal and bacterial infections common in transplant recipients.
 
Nagarajan Vaidehi, Ph.D. - Devises computational approaches
Dr. Vaidehi devises computational approaches to study the structure, function and dynamics of G-protein coupled receptors. Of particular interest is the interaction of chemokines, and antagonists to the chemokine receptors, that trigger leukocyte migration in immune response and inflammation. By predicting binding-site interactions of agonists and antagonists with the receptors, the drug development process is greatly streamlined.
 
Zuoming Sun, Ph.D. - Studies the mechanisms controlling T-cell activation and survival
Dr. Sun’s lab studies the mechanisms controlling T-cell activation and survival. Activation and survival of T-lymphocytes control the quality and magnitude of immune response. Manipulation of T-cell activity is therefore one of the most important treatments for 1) enhancing immune responses against pathogens and tumors and 2) inhibiting the immune responses involved in autoimmune diseases and transplant rejection.
 

Immunology Faculty

Immunology

Immunology

City of Hope’s Department of Immunology, one ofeight major basic science (“Laboratory Research”) departments of the Beckman Research Institute, was established in 1972 by Charles Todd. At that time, immune-based therapies were used on a very limited basis in cancer treatment, reserved for conditions such as malignant melanoma and bladder cancer. Most immunotherapy treatments consisted of agents such as BCG and interferon.

In recent years, the field of cancer immunology has grown by leaps and bounds, and a wide range of neoplastic diseases, including both hematologic malignancies and solid tumors,are routinely being treated with a well-stocked armamentarium of monoclonal antibodies and other immunotherapy methods.

The Department of Immunology continues its original vision, with a dual focus on both immunology and structural biology. It has seven principal investigators with research interests in cell and tumor immunology and structure analysis, who are aided by state-of-the-art facilities in mass spectrometry and NMR, as well as a computer cluster for computational chemistry.

The unique combination of biological and structural studies and the intensive exploration of structure-function relationships have created a thriving, productive environment that has encouraged fruitful collaboration among investigators at City of Hope and at other institutions.
 
Laboratory Research

John Shively, Ph.D. -  CEA (carcinoembryonic antigen) gene family
Dr. Shively's lab specializes in the CEA (carcinoembryonic antigen) gene family. In particular, he is researching the use of anti-CEA antibodies for tumor imaging and therapy and the role of CEACAM1 in T-cell activation and mammary epithelial cell polarization.  He is also exploring the relationship of the immune system and genetics to fibromyalgia.
 
Terry Lee, Ph.D. - Optimizing the application of biomolecule mass spectrometry
Dr. Lee’s focus is optimizing the application of biomolecule mass spectrometry to “real-world” biological problems. He develops new methods for proteomic analyses by mass spectrometry including integrated microfluidic systems for sample preparation and automated methods of data acquisition and analysis.
 
Markus Kalkum, Ph.D. - Develops novel biochemical and mass spectrometric methods
Dr. Kalkum develops novel biochemical and mass spectrometric methods for the sensitive detection of functional biomolecules in complex samples. His goal is to improve the early diagnosis of emerging and frequently under-diagnosed diseases, including opportunistic fungal and bacterial infections common in transplant recipients.
 
Nagarajan Vaidehi, Ph.D. - Devises computational approaches
Dr. Vaidehi devises computational approaches to study the structure, function and dynamics of G-protein coupled receptors. Of particular interest is the interaction of chemokines, and antagonists to the chemokine receptors, that trigger leukocyte migration in immune response and inflammation. By predicting binding-site interactions of agonists and antagonists with the receptors, the drug development process is greatly streamlined.
 
Zuoming Sun, Ph.D. - Studies the mechanisms controlling T-cell activation and survival
Dr. Sun’s lab studies the mechanisms controlling T-cell activation and survival. Activation and survival of T-lymphocytes control the quality and magnitude of immune response. Manipulation of T-cell activity is therefore one of the most important treatments for 1) enhancing immune responses against pathogens and tumors and 2) inhibiting the immune responses involved in autoimmune diseases and transplant rejection.
 

Immunology Faculty

Immunology Faculty

Overview
Beckman Research Institute of City of Hope is responsible for fundamentally expanding the world’s understanding of how biology affects diseases such as cancer, HIV/AIDS and diabetes.
 
 
Research Departments/Divisions

City of Hope is a leader in translational research - integrating basic science, clinical research and patient care.
 

Research Shared Services

City of Hope embodies the spirit of scientific collaboration by sharing services and core facilities with colleagues here and around the world.
 

Our Scientists

Our research laboratories are led by the best and brightest minds in scientific research.
 

City of Hope’s Irell & Manella Graduate School of Biological Sciences equips students with the skills and strategies to transform the future of modern medicine.
Develop new therapies, diagnostics and preventions in the fight against cancer and other life-threatening diseases.
 


NEWS & UPDATES
  • Cancer cells are voracious eaters. Like a swarm of locusts, they devour every edible tidbit they can find. But unlike locusts, when the food is gone, cancer cells can’t just move on to the next horn o’ plenty. They have to survive until more food shows up — and they do. Mei Kong, Ph.D., assistant […]
  • On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the parade is “Inspiring Stories.” Repr...
  • When 25-year-old Angelina Mattos was diagnosed with Stage 4 oral cancer earlier this year, she learned that her only hope of survival was through the removal of her tongue, a surgery that leaves people without the ability to talk or eat normally, sometimes permanently ending their ability to speak. After hearin...
  • Two years ago, Joselyn Miller and her family sat together as stem cells from her brother’s bone marrow were infused into her – a precious gift of life that the family is excited to have the chance to pass to another patient in need. Today, the stem cell recipient is healthy. Her 23-year-old son Rex, who […...
  • Even as the overall rate of oral cancers in the United States steadily declines, the rate of tongue cancer is increasing — especially among white females ages 18 to 44. An oral cancer diagnosis, although rare, is serious. Only half of the people diagnosed with oral cancer are still alive after five years, accor...
  • Sometimes cancer found in the lungs is not lung cancer at all. It can be another type of cancer that originated elsewhere in the body and spread, or metastasized, to the lungs through the bloodstream or lymphatic system. These tumors are called lung metastases, or metastatic cancer to the lungs, and are not the...
  • When it comes to research into the treatment of hematologic cancers, City of Hope scientists stand out. One study that  they presented this week at the annual meeting of the American Society of Hematology suggests a new standard of care for HIV-associated lymphoma, another offers promise for the treatment of re...
  • Patients with HIV-associated lymphoma may soon have increased access to the current standard of care for some non-HIV infected patients – autologous stem cell transplants. Impressive new data, presented Monday at the annual meeting of the American Society of Hematology (ASH) in San Francisco, indicate that HIV-...
  • On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the Rose Parade is “Inspiring Stories.”...
  • The holidays can create an overwhelming urge to give to people in need — especially to sick children and families spending the holidays in a hospital room. That’s a good thing. Holiday donations of toys and gifts can bolster the spirits, and improve the lives, of people affected by illness, and hospitals ...
  • On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the parade is “Inspiring Stories.” Here...
  • Cancer has a way of “talking” to the immune system and corrupting it to work on its own behalf instead of defending the body. Blocking this communication would allow the immune system to see cancer cells for what they are – something to be fought off – and stop them from growing. A breakthrough Scientists [R...
  • On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the parade is “Inspiring Stories.” By V...
  • On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the parade is “Inspiring Stories.” The ...
  • On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the parade is “Inspiring Stories.” In 2...