A National Cancer Institute-designated Comprehensive Cancer Center

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Comprehensive Cancer Center

City of Hope has a proud history of excellence in biomedical research, patient-centered medical care, and community outreach.
 
In recognition of our broad-based innovations in cancer research and treatment, our continuing commitment to compassionate patient care, and our initiatives in patient and community education, the National Cancer Institute (NCI) has designated City of Hope a Comprehensive Cancer Center — the highest level of recognition bestowed by the NCI. City of Hope is one of just a handful of elite institutions nationwide to receive this prestigious honor.
 
As a division of the National Institutes of Health, the NCI is the Federal Government's principal agency for cancer research and training. The NCI's Cancer Center program acknowledges institutions for their scientific excellence, as well as their ability to bring diverse research approaches to the problem of cancer. The "Comprehensive Cancer Center" designation indicates that City of Hope has undergone a rigorous review process and has met or exceeded NCI standards in these areas.
 

City of Hope Comprehensive Cancer Center researchers and resources are dedicated to developing innovative new disease-fighting strategies in the battle against cancer. Through these programs, and through the mission and vision of City of Hope physicians and scientists, City of Hope Comprehensive Cancer Center will continue to make a difference in the lives of current and potential cancer patients and their loved ones—around the world today and in the future.
 
 
All of these activities are made possible by a forward-thinking infrastructure supporting basic and translational research in biological and small molecule cancer therapeutics.
 

Cancer Center Leadership

Cancer Center Program Co-leaders

About Our Cancer Center Research Programs

City of Hope provides a multidisciplinary, interactive environment where basic, clinical and translational, and prevention and control scientists collaborate closely. This stimulating intellectual environment contributes to the productive translational research under way within the Comprehensive Cancer Center. Our research initiatives are divided into the following research programs:
 
Basic Science Research Program

The Comprehensive Cancer Center provides both the infrastructure and the environment for outstanding basic science research. ("Basic science" refers to research conducted in a laboratory setting.) In turn, this research contributes to our understanding of the underlying genetic, molecular and biological bases of cancer. The basic science research program at City of Hope is called Molecular Oncology (MONC).
 
Clinical and Translational Research Programs

The Comprehensive Cancer Center's clinical and translational research programs focus on the translation of novel laboratory observations into the treatment of patients (and their families) and, ultimately, throughout the world. The number of the Center's novel (Phases I and I/II) clinical trials increases yearly. The clinical and translational science research programs are:
 
 
Prevention and Control Program
 
Cancer prevention and control research at the Comprehensive Cancer Center is conducted within a program on Cancer Control and Population Sciences (CCPS). The members of this research program cover an extensive spectrum of disciplines, which is further broadened by additional collaborations with physician investigators. Such a confederation of expertise, working within a collaborative environment, maximizes productive interaction. The program focuses on four important areas of concentration:
 
  • Host and environmental determinants of cancer
  • Health-related outcomes and quality of life after cancer
  • Interventional studies to reduce cancer-related morbidity
  • Educational initiatives
 
Our five research programs, described above, represent a continuum, as shown in the figure below. Basic and translational studies can originate in either the basic science program,MO or the DCT Program. These studies can then link to phase I and II clinical protocols in all three clinical programs—DCT, CI and HM. They can also integrate into follow-up studies in survivorship and symptom management in the CCPS Program. On this continuum, CI spans both translational and clinical research, whereas HM is predominantly (but not exclusively) clinical. Frequent interaction between the principal investigators of each program ensures maximum benefit from shared insights. All these activities are made possible by City of Hope’s infrastructure, which supports basic and translational research in biological and in small molecule approaches to cancer.

The arrow in the figure below represents our realization that, even as activities move to the right toward clinical realization, there is a strong requirement to recycle back to developmental activities in response to the knowledge we gain in early clinical application. Our scientists are already doing this routinely, aided by our flexible and responsive infrastructure. The CCPS Program also contributes to the cycle by providing downstream information on effects of therapy and also potential prevention and therapeutic targets — findings arising out of survivorship and molecular epidemiological work of CCPS. These findings may then be explored by other programs in the continuum.
 
 
 

Community Outreach

As a Comprehensive Cancer Center, City of Hope plays an important role in the community. We continually use the knowledge gained from our ongoing research to influence the standards of prevention and care, and to educate physicians, caregivers, and patients alike.
 
 

Why Choose a Comprehensive Cancer Center?

Only a National Cancer Institute (NCI)-designated Comprehensive Cancer Center such as City of Hope offers a full complement of services designed to address all aspects of cancer, from understanding its origins, to developing new therapies and testing them in patient clinical trials, to delivering superior patient care and providing support and education to patients, their families and the public.
 
City of Hope is one of a select few cancer centers nationwide to have received this prestigious honor. NCI-funded cancer centers must go through a rigorous review process every five years, in which they are evaluated and ranked. Only those conducting the most promising cancer research are awarded Comprehensive Cancer Center status. It is an important credential to consider when choosing a cancer treatment facility.
 
As a patient, a diagnosis of cancer brings with it many questions and concerns. Choosing a Comprehensive Cancer Center such as City of Hope is an empowering step, equipping you with the best possible resources to fight the disease.
 
Attributes of a Comprehensive Cancer Center
To achieve the Comprehensive Cancer Center designation, organizations must support a broad range of research programs and approach the problem of cancer in many different ways. Comprehensive Cancer Centers like City of Hope must have strong programs in all of the following areas:
 
Comprehensive Cancer Centers also play important roles in their communities and regions, and influence the standards of prevention and care.
 
National Comprehensive Cancer Network Founding Member
Of the relatively few NCI-designated Comprehensive Cancer Centers, only an elite 21 comprise the National Comprehensive Cancer Network ( NCCN ), an alliance of the nation's leading Comprehensive Cancer Centers that defines and sets standards for cancer care. City of Hope is proud to be a founding member of the NCCN. NCCN member institutions are recognized for their world-renowned experts and for dealing with particularly complex, rare and aggressive forms of cancer. As an NCCN member institution, City of Hope plays a critical role in advancing state-of-the-art cancer treatment through education, research, and patient care. Learn more about the NCCN at www.nccn.org.
 

Comprehensive Cancer Center

Comprehensive Cancer Center

City of Hope has a proud history of excellence in biomedical research, patient-centered medical care, and community outreach.
 
In recognition of our broad-based innovations in cancer research and treatment, our continuing commitment to compassionate patient care, and our initiatives in patient and community education, the National Cancer Institute (NCI) has designated City of Hope a Comprehensive Cancer Center — the highest level of recognition bestowed by the NCI. City of Hope is one of just a handful of elite institutions nationwide to receive this prestigious honor.
 
As a division of the National Institutes of Health, the NCI is the Federal Government's principal agency for cancer research and training. The NCI's Cancer Center program acknowledges institutions for their scientific excellence, as well as their ability to bring diverse research approaches to the problem of cancer. The "Comprehensive Cancer Center" designation indicates that City of Hope has undergone a rigorous review process and has met or exceeded NCI standards in these areas.
 

City of Hope Comprehensive Cancer Center researchers and resources are dedicated to developing innovative new disease-fighting strategies in the battle against cancer. Through these programs, and through the mission and vision of City of Hope physicians and scientists, City of Hope Comprehensive Cancer Center will continue to make a difference in the lives of current and potential cancer patients and their loved ones—around the world today and in the future.
 
 
All of these activities are made possible by a forward-thinking infrastructure supporting basic and translational research in biological and small molecule cancer therapeutics.
 

Cancer Center Leadership

Cancer Center Leadership

Cancer Center Program Co-leaders

Cancer Center Program Co-leaders

Cancer Center Research Programs

About Our Cancer Center Research Programs

City of Hope provides a multidisciplinary, interactive environment where basic, clinical and translational, and prevention and control scientists collaborate closely. This stimulating intellectual environment contributes to the productive translational research under way within the Comprehensive Cancer Center. Our research initiatives are divided into the following research programs:
 
Basic Science Research Program

The Comprehensive Cancer Center provides both the infrastructure and the environment for outstanding basic science research. ("Basic science" refers to research conducted in a laboratory setting.) In turn, this research contributes to our understanding of the underlying genetic, molecular and biological bases of cancer. The basic science research program at City of Hope is called Molecular Oncology (MONC).
 
Clinical and Translational Research Programs

The Comprehensive Cancer Center's clinical and translational research programs focus on the translation of novel laboratory observations into the treatment of patients (and their families) and, ultimately, throughout the world. The number of the Center's novel (Phases I and I/II) clinical trials increases yearly. The clinical and translational science research programs are:
 
 
Prevention and Control Program
 
Cancer prevention and control research at the Comprehensive Cancer Center is conducted within a program on Cancer Control and Population Sciences (CCPS). The members of this research program cover an extensive spectrum of disciplines, which is further broadened by additional collaborations with physician investigators. Such a confederation of expertise, working within a collaborative environment, maximizes productive interaction. The program focuses on four important areas of concentration:
 
  • Host and environmental determinants of cancer
  • Health-related outcomes and quality of life after cancer
  • Interventional studies to reduce cancer-related morbidity
  • Educational initiatives
 
Our five research programs, described above, represent a continuum, as shown in the figure below. Basic and translational studies can originate in either the basic science program,MO or the DCT Program. These studies can then link to phase I and II clinical protocols in all three clinical programs—DCT, CI and HM. They can also integrate into follow-up studies in survivorship and symptom management in the CCPS Program. On this continuum, CI spans both translational and clinical research, whereas HM is predominantly (but not exclusively) clinical. Frequent interaction between the principal investigators of each program ensures maximum benefit from shared insights. All these activities are made possible by City of Hope’s infrastructure, which supports basic and translational research in biological and in small molecule approaches to cancer.

The arrow in the figure below represents our realization that, even as activities move to the right toward clinical realization, there is a strong requirement to recycle back to developmental activities in response to the knowledge we gain in early clinical application. Our scientists are already doing this routinely, aided by our flexible and responsive infrastructure. The CCPS Program also contributes to the cycle by providing downstream information on effects of therapy and also potential prevention and therapeutic targets — findings arising out of survivorship and molecular epidemiological work of CCPS. These findings may then be explored by other programs in the continuum.
 
 
 

Community Outreach

Community Outreach

As a Comprehensive Cancer Center, City of Hope plays an important role in the community. We continually use the knowledge gained from our ongoing research to influence the standards of prevention and care, and to educate physicians, caregivers, and patients alike.
 
 

Why Choose A Comprehensive Cancer Center?

Why Choose a Comprehensive Cancer Center?

Only a National Cancer Institute (NCI)-designated Comprehensive Cancer Center such as City of Hope offers a full complement of services designed to address all aspects of cancer, from understanding its origins, to developing new therapies and testing them in patient clinical trials, to delivering superior patient care and providing support and education to patients, their families and the public.
 
City of Hope is one of a select few cancer centers nationwide to have received this prestigious honor. NCI-funded cancer centers must go through a rigorous review process every five years, in which they are evaluated and ranked. Only those conducting the most promising cancer research are awarded Comprehensive Cancer Center status. It is an important credential to consider when choosing a cancer treatment facility.
 
As a patient, a diagnosis of cancer brings with it many questions and concerns. Choosing a Comprehensive Cancer Center such as City of Hope is an empowering step, equipping you with the best possible resources to fight the disease.
 
Attributes of a Comprehensive Cancer Center
To achieve the Comprehensive Cancer Center designation, organizations must support a broad range of research programs and approach the problem of cancer in many different ways. Comprehensive Cancer Centers like City of Hope must have strong programs in all of the following areas:
 
Comprehensive Cancer Centers also play important roles in their communities and regions, and influence the standards of prevention and care.
 
National Comprehensive Cancer Network Founding Member
Of the relatively few NCI-designated Comprehensive Cancer Centers, only an elite 21 comprise the National Comprehensive Cancer Network ( NCCN ), an alliance of the nation's leading Comprehensive Cancer Centers that defines and sets standards for cancer care. City of Hope is proud to be a founding member of the NCCN. NCCN member institutions are recognized for their world-renowned experts and for dealing with particularly complex, rare and aggressive forms of cancer. As an NCCN member institution, City of Hope plays a critical role in advancing state-of-the-art cancer treatment through education, research, and patient care. Learn more about the NCCN at www.nccn.org.
 
Research Shared Services

City of Hope embodies the spirit of scientific collaboration by sharing services and core facilities with colleagues here and around the world.
 

Clinical Trials
Our aggressive pursuit to discover better ways to help patients now – not years from now – places us among the leaders worldwide in the administration of clinical trials.
 
Learn more about City of Hope's institutional distinctions, breakthrough innovations and collaborations.
Discover the wide range of progressive cancer treatment options at City of Hope designed to meet the individual needs of each patient. Here, medical research and clinical care are integrated, speeding the application of scientific discoveries toward better, more effective patient cancer treatments.
City of Hope Breakthroughs
Get the latest in City of Hope's research, treatment and news you can use on our blog, Breakthroughs.
 
 
When you support City of Hope, you help us shorten the time it takes to get from bold, innovative ideas to powerful new medical treatments. Make a gift online now.


NEWS & UPDATES
  • Patients with metastatic colorectal cancer often stop responding to the primary drugs used against the disease, leaving them with few options and little hope. Determined to increase those options, doctors and researchers at City of Hope are conducting two clinical trials that could lead to new treatments for pe...
  • Investigators working at City of Hope are making many significant inroads against many forms of cancer. To do that, they have to take a variety of approaches. Molecular oncology researchers focus on abnormal cancer-associated activity in a cell’s nucleus. One especially prominent factor in many breast and ovari...
  • In light of the new breast cancer screening guidelines, which call for women to have mammograms every other year from age 50 to 74, it’s more important than ever for women to understand their individual risk. On Monday, the U.S. Preventive Services Task force released new breast cancer screening guideline...
  • Cancer patients need, and deserve, more than medical care. They and their families need high-quality supportive care – that is, care that addresses their physical, emotional and spiritual well-being. Health care professionals increasingly understand this, but starting such programs from scratch isn’t easy...
  • Each year, City of Hope patients given another chance at life gather to pose for a picture like this one. Going on its 39th year, the celebration of patients free of blood cancers thanks to bone marrow or stem cell transplants has grown such that a photographer has to scale a cherry picker just to […]
  • Cancer patients who are participating in early-stage clinical trials need extra emotional and physical support due to their additional stress and often unique symptoms. Now an effort by researchers at City of Hope to create a model for such support has received a $6.8 million grant from the National Cancer Inst...
  • The need for improvements in treating malignant brain tumors has never been greater. Survival for many patients with these tumors are sometimes measured in just months. One reason that therapeutic options are limited is that traditional surgery is deemed too risky for many brain tumors, especially for those in ...
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  • As far back as he can remember, Jonathan Yamzon, M.D., wanted to be a doctor. “I knew it from the get-go,” he said, matter-of-factly. “I always envisioned it as the ideal; the supreme thing one could do with one’s life.” The youngest of six children, Yamzon was barely a toddler when his family moved to [&...
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  • Health care decisions are tough. They’re even tougher when you – or loved ones – have to make them without a plan or a conversation. National Healthcare Decisions Day, on April 16,  is a nationwide initiative to demystify the health care decision-making process and encourage families to start talking. Ult...
  • The statistics, direct from the American Cancer Society, are sobering: Cancer death rates among African-American men are 27 percent higher than for white men. The death rate for African-American women is 11 percent higher compared to white women. Hispanics have higher rates of cervical, liver and stomach cancer...
  • “Lucky” is not usually a term used to describe someone diagnosed with cancer.  But that’s how 34-year-old Alex Camargo’s doctor described him when he was diagnosed with thyroid cancer — the disease is one of the most treatable cancers at all stages. That doctor was ultimately proved righ...
  • Geoff Berman, 61, starts his day with the motto: “The sun is up. I’m vertical. It’s a good day.” Ever since he’s been in remission from lymphoma, Berman makes a special point of being grateful for each day, reminding himself that being alive is a gift. “I just enjoy living,” he said. “I give e...