A National Cancer Institute-designated Comprehensive Cancer Center

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Colorectal Cancer

At City of Hope, a multidisciplinary team of nationally recognized experts in the research, diagnosis and treatment of gastrointestinal cancer provides outstanding medical care to patients with colon and rectal cancers. We are experts in treating patients with early to advanced colon and rectal cancers, including:
 
  • Adenocarcinoma
  • Leiomyosarcoma
  • Lymphoma
  • Melanoma
  • Neuroendocrine tumors
 
City of Hope researchers and physicians have pioneered new methods of treating colon and rectal cancers. Our approach to treating colon and rectal cancers combines aggressive therapies, minimally invasive and robotic-assisted surgery, and state-of-the-art technologies with highly compassionate care to give patients the best possible outcomes. Treatment for colon and rectal cancers may involve:
 
  • Surgery
  • Radiation therapy, including helical TomoTherapy
  • Chemotherapy
  • Chemoradiation
  • Heated intraperitoneal chemotherapy (HIPEC)
 
Through our clinical trials research program — among the most extensive in the nation — we can often provide patients with access to promising new anticancer drugs and technologies not available elsewhere.
 
About Colorectal Cancer
 
  • The colon and rectum are parts of the body’s gastrointestinal system, also called the digestive tract.  After food is digested in the stomach and nutrients are absorbed in the small intestine, the remaining material moves down into the lower large intestine (colon) where water and nutrients are absorbed.  The lower parts of the digestive tract include the rectum and anus, through which stool (solid waste) travels as it passes from the body.
  • Colorectal cancer (cancer of the colon or rectum) occurs when abnormal cells in the colon or rectum start to divide uncontrollably, forming a malignant (cancerous) tumor.
  • Cancer cells may invade the healthy tissues around them and spread (metastasize) to other parts of the body such as the liver and lung.  After treatment, some cancers may come back (recur).
 
Colorectal Risk Factors
 
Certain factors increase your risk of developing colon cancer. These include:
 
  • Age older than 50
  • Personal history of colorectal disorders:
    • Previous diagnosis of colorectal cancer
    • History of precancerous polyps
    • History of inflammatory bowel disease (Crohn’s disease, ulcerative colitis)
  • Family history of colorectal cancer, especially before age 60
  • Hereditary syndromes
    • HNPCC (hereditary non-polyposis colorectal cancer)
    • FAP (familial adenomatous polyposis)
  • Diabetes
  • Ethnicity
    • Eastern European Jewish heritage
    • African-American heritage
  • Lifestyle factors
    • High-fat diet from animal sources, especially red meats and processed meats
    • Lack of exercise
    • Obesity
    • Cigarette smoking
    • Heavy consumption of alcohol

Colorectal Symptoms

Possible signs of cancer of the colon and/or rectum include a change in bowel habits or blood in the stool. These and other symptoms may be caused by colon and/or rectum cancer. Other conditions may cause the same symptoms. A doctor should be consulted if any of the following problems occur:
 
  • A change in bowel habits
  • Blood (either bright red or very dark) in the stool
  • Diarrhea, constipation, or feeling that the bowel does not empty completely
  • Stools that are narrower than usual
  • Frequent gas pains, bloating, fullness, or cramps•Weight loss for no known reason
  • Feeling very tired
  • Vomiting

How We Screen and Diagnose Colorectal Cancer

Prevention
 
Some people have a higher risk for colorectal cancer due to genetics, family history, age or environmental/lifestyle factors. City of Hope’s Cancer Screening & Prevention Program combines clinical, research and educational initiatives to identify people who may be at increased risk for developing colorectal cancer.Because of these factors, reduce risk factors in this population wherever possible, and utilize the latest technologies for prevention and early detection of colorectal cancer.

Screening
 
Colorectal screening allows doctors to find and remove polyps (small areas of tissue that can become cancerous), as well as discover colorectal tumors at an early stage, rather than waiting for symptoms to occur.

General guidelines for colorectal screening are as follows:
 
  • Colonoscopy every 10 years, beginning at age 50
 
  • Annual fecal occult blood test (described below), preferably combined with sigmoidoscopy every five years.

City of Hope recommends patients talk with their physician about when to begin screening for colorectal cancer. A colonoscopy may be advisable more frequently for individuals with polyps, inflammatory bowel disease, previous colorectal cancer and family members with colon cancer.

Diagnosing
 
Several different types of tests are used to examine the colon, rectum and stool for evidence of colon cancer, including:

  • Physical exam and history
 
  • Fecal occult blood test
    Small samples of stool are placed on chemically treated cards and examined for the microscopic presence of blood.
 
  • Digital rectal exam
    A doctor inserts a lubricated, gloved finger into the rectum to feel for lumps or abnormal areas.
 
  • Barium enema (also known as a lower GI series)
    For this examination, a liquid containing barium is placed into the rectum, which makes the colon and rectum easier to see in an X-ray.
 
  • Sigmoidoscopy
    In this test, a sigmoidoscope (a thin, lighted tube) is inserted through the rectum into the sigmoid colon. During the procedure, polyps or tissue samples may be removed for biopsy.
 
  • Colonoscopy
    A colonoscopy allows doctors to examine the entire colon and rectum for polyps, abnormal areas or cancer. In this test, a colonoscope (a thin, lighted tube) is inserted through the rectum into the colon and polyps or tissue samples may be taken for biopsy. Some colon polyps can be removed entirely during this procedure, which is performed under sedation.
 
  • Biopsy
    Tissue samples are examined under the microscope to determine what types of cells are present.
 
  • Virtual colonoscopy
    Also called colonography or CT colonography, this procedure uses a series of X-rays to create detailed pictures of the colon. The images are combined by computer in a process called computed tomography, or CT, to create detailed two- and three-dimensional images that can reveal polyps and other abnormalities inside the colon.
 
 

Our Treatment Approach to Colorectal Cancer

City of Hope brings together the most advanced resources to manage the treatment of patients with early and advanced colorectal cancers. Our team includes gastroenterologists, medical oncologists, radiation oncologists and surgical oncologists working cooperatively to create the most effective treatment plan.

In addition to conventional therapies, our clinical research programs offer patients access to promising new treatments.

Surgery
Surgery to remove cancerous tissue is a primary treatment at all stages of colorectal cancer. City of Hope surgeons are among the most experienced in the U.S. at treating colon cancer, and have excellent success rates using a range of advanced technologies.

Minimally Invasive and Laparoscopic Surgery
Surgery is the primary treatment used for localized tumors. When applicable, our specialists utilize minimally invasive surgery with advanced technologies such as laparoscopy and the new da Vinci S Surgical System with robotic capabilities that allows for greater precision. These surgeries feature small incisions and potentially:
 
  • Less blood loss, pain and visible incisions
  • Shorter hospital stays and recovery time
  • Fewer complications and quicker return to normal activities

One of the following surgical procedures may be used:
 
  • Local excision
    This surgery (sometimes called a polypectomy) is used to remove precancerous polyps and very small colon cancers.
  • Resection
    If a cancer is larger, a partial colectomy (removing the cancer and a margin of healthy tissue around it) may be performed. Lymph nodes near the colon may also be taken out and examined for signs of cancer. Usually, the surgeon will reattach the healthy parts of the colon back together.
  • Resection and colostomy
    In rare cases, the remaining parts of the colon cannot be reattached. Instead, an opening (stoma) is created on the outside of the body for waste to pass through. This procedure, called a colostomy, may be required only for a few months until the lower colon has healed, after which it can be reversed. However, if the entire lower colon needs to be removed, the colostomy may be permanent.
  • Radiofrequency ablation
    This procedure uses a special probe that kills cancer cells with electrical current. The probe may be inserted directly through the skin, or through an incision in the abdomen. Radiofrequency ablation is sometimes used to treat liver metastases from colon and rectal cancers.

Radiation and chemotherapy
Even if the surgeon can remove all signs of cancer that can be seen during an operation, patients may be given additional treatments. These may include chemotherapy or radiation therapy following surgery to kill any residual cancer cells.

Treatment given after surgery is called adjuvant therapy. In some patients with rectal cancer, chemotherapy and radiation therapy may be given before their operation to reduce the size of the tumor. This is called neoadjuvant therapy.

Radiation Therapy
Radiation therapy uses high-energy X-rays or other types of radiation to kill cancer cells. Our Department of Radiation Oncology was the first in the western United States to offer the Helical TomoTherapy Hi-Art System , one of the first radiation therapy systems of its kind to incorporate not only radiation therapy, but also tumor imaging capabilities comparable to a diagnostic computed tomography (CT) scan.

The helical TomoTherapy Hi-Art system integrates two types of technology – spiral CT scanning and intensity modulated radiation therapy, or IMRT – thus producing hundreds of pencil beams of radiation (each varying in intensity) that rotate spirally around a tumor. The high-dose region of radiation can be shaped or sculpted to fit the exact shape of each patient’s tumor, resulting in more effective and potentially curative doses to the cancer. This also reduces damage to normal tissues and results in fewer complications.

Chemotherapy
Chemotherapy drugs destroy cancer cells by interfering with their growth and multiplication. There are several methods by which these cancer-fighting medicines are delivered. In particular, City of Hope has been a pioneer in furthering the use of infusion chemotherapy to treat liver metastases arising from colorectal cancer.

Patients with liver metastases are evaluated for either resection or radiofrequency ablation. During surgery, a continuous infusion pump is placed under the skin to deliver anticancer medicine directly to the liver, in addition to chemotherapy given through a vein. This approach, called regional chemotherapy, has made major advances in controlling the spread of colorectal cancer.

Chemoradiation
Chemoradiation combines chemotherapy with radiation therapy to increase the effects of both. This strategy is often used for rectal cancers.

Heated Intraperitoneal Chemotherapy (HIPEC)
In the HIPEC procedure, the surgeon uses a special machine to pump high doses of heated chemotherapy drugs into the peritoneal cavity (the inner lining of the abdomen) while still in the operating room. The machine circulates the solution through the patient for up to two hours to reliably attack and eliminate any residual cancer cells that may remain after surgery. By bathing the abdomen with heated chemotherapy immediately following surgery, a higher dose of medication can be used than would normally be tolerated by a patient if given intravenously -- the traditional way chemotherapy is administered.

This type of chemotherapy is best at destroying cancer cells that are too small to be seen with the naked eye and prevents these cells from being left behind to form new cancerous tumors in the abdomen. The procedure also improves drug absorption and effect with minimal exposure to the rest of the body. In this way, the normal side effects of chemotherapy can be avoided.

Colorectal Cancer Resources

All of our colorectal cancer patients have access to the Sheri & Les Biller Patient and Family Resource Center, which offers a wide array of support and educational services. Patients and loved ones may work with a coordinated group of social workers, psychiatrists, psychologists, patient navigators, pain management specialists and spiritual care providers at the center, as well as participate in programs such as music therapy, meditation and many others.
 
Additional Resources
C3-Colorectal Cancer Coalition
703-548-1225
C3 pushes for research to improve screening, diagnosis and treatment of colorectal cancer and encourages legislation for policy decisions.
 
Colon Cancer Alliance
877-422-2030
The Colon Cancer Alliance is a national patient advocacy organization that provides patient support, education and research information across North America.
 
American Cancer Society
800-ACS-2345
866-228-4327 for TYY
The American Cancer Society has many national and local programs, as well as a 24-hour support line, to help cancer survivors with problems such as travel, lodging and emotional issues.
 
National Comprehensive Cancer Network (NCCN)
888-909-NCCN (6226)
The National Comprehensive Cancer Network, an alliance of 19 of the world's leading cancer centers, is an authoritative source of information to help patients and health professionals make informed decisions about cancer care.
 
National Cancer Institute (NCI)
800-4-CANCER
The National Cancer Institute, established under the National Cancer Act of 1937, is the federal government's principal agency for cancer research and training.
 
U.S. Dept. of Health & Human Services National Institutes of Health (NIH)
301-496-4000
301-402-9612 for TYY
The National Institutes of Health (NIH) is one of the world's foremost medical research centers, and the federal focal point for medical research in the United States. The NIH, comprising 27 separate institutes and centers, is one of eight health agencies of the Public Health Service, which, in turn, is part of the U.S. Department of Health & Human Services.
 

City of Hope Colorectal Cancer Research and Clinical Trials

City of Hope has long been a leader in cancer research, including colorectal cancers. We are currently conducting multiple clinical trials of new chemotherapy drugs and other agents that may improve outcomes for patients with regionally metastatic and advanced disease, and prevent recurrence after treatment of early colorectal cancer.
 
Through our research program, patients gain access to promising new anticancer drugs and technologies that are not available to the general public. As a patient at City of Hope, you may qualify to participate in a test of these new investigational therapies.
 
Learn more about our clinical trials program and specifically about trials for colorectal cancer.
 
 

Colorectal Cancer Team

Support this program

It takes the help of a lot of caring people to make hope a reality for our patients. City of Hope was founded by individuals' philanthropic efforts 100 years ago. Their efforts − and those of our supporters today − have built the foundation for the care we provide and the research we conduct. It enables us to strive for new breakthroughs and better therapies − helping more people enjoy longer, better lives.

For more information on supporting this specific program, please contact us below.

Joe Komsky
Senior Director
Phone: 213-241-7293
Email: jkomsky@coh.org

 
 

Colorectal Cancer

Colorectal Cancer

At City of Hope, a multidisciplinary team of nationally recognized experts in the research, diagnosis and treatment of gastrointestinal cancer provides outstanding medical care to patients with colon and rectal cancers. We are experts in treating patients with early to advanced colon and rectal cancers, including:
 
  • Adenocarcinoma
  • Leiomyosarcoma
  • Lymphoma
  • Melanoma
  • Neuroendocrine tumors
 
City of Hope researchers and physicians have pioneered new methods of treating colon and rectal cancers. Our approach to treating colon and rectal cancers combines aggressive therapies, minimally invasive and robotic-assisted surgery, and state-of-the-art technologies with highly compassionate care to give patients the best possible outcomes. Treatment for colon and rectal cancers may involve:
 
  • Surgery
  • Radiation therapy, including helical TomoTherapy
  • Chemotherapy
  • Chemoradiation
  • Heated intraperitoneal chemotherapy (HIPEC)
 
Through our clinical trials research program — among the most extensive in the nation — we can often provide patients with access to promising new anticancer drugs and technologies not available elsewhere.
 
About Colorectal Cancer
 
  • The colon and rectum are parts of the body’s gastrointestinal system, also called the digestive tract.  After food is digested in the stomach and nutrients are absorbed in the small intestine, the remaining material moves down into the lower large intestine (colon) where water and nutrients are absorbed.  The lower parts of the digestive tract include the rectum and anus, through which stool (solid waste) travels as it passes from the body.
  • Colorectal cancer (cancer of the colon or rectum) occurs when abnormal cells in the colon or rectum start to divide uncontrollably, forming a malignant (cancerous) tumor.
  • Cancer cells may invade the healthy tissues around them and spread (metastasize) to other parts of the body such as the liver and lung.  After treatment, some cancers may come back (recur).
 
Colorectal Risk Factors
 
Certain factors increase your risk of developing colon cancer. These include:
 
  • Age older than 50
  • Personal history of colorectal disorders:
    • Previous diagnosis of colorectal cancer
    • History of precancerous polyps
    • History of inflammatory bowel disease (Crohn’s disease, ulcerative colitis)
  • Family history of colorectal cancer, especially before age 60
  • Hereditary syndromes
    • HNPCC (hereditary non-polyposis colorectal cancer)
    • FAP (familial adenomatous polyposis)
  • Diabetes
  • Ethnicity
    • Eastern European Jewish heritage
    • African-American heritage
  • Lifestyle factors
    • High-fat diet from animal sources, especially red meats and processed meats
    • Lack of exercise
    • Obesity
    • Cigarette smoking
    • Heavy consumption of alcohol

Colorectal Symptoms

Possible signs of cancer of the colon and/or rectum include a change in bowel habits or blood in the stool. These and other symptoms may be caused by colon and/or rectum cancer. Other conditions may cause the same symptoms. A doctor should be consulted if any of the following problems occur:
 
  • A change in bowel habits
  • Blood (either bright red or very dark) in the stool
  • Diarrhea, constipation, or feeling that the bowel does not empty completely
  • Stools that are narrower than usual
  • Frequent gas pains, bloating, fullness, or cramps•Weight loss for no known reason
  • Feeling very tired
  • Vomiting

How We Screen and Diagnose Colorectal Cancer

How We Screen and Diagnose Colorectal Cancer

Prevention
 
Some people have a higher risk for colorectal cancer due to genetics, family history, age or environmental/lifestyle factors. City of Hope’s Cancer Screening & Prevention Program combines clinical, research and educational initiatives to identify people who may be at increased risk for developing colorectal cancer.Because of these factors, reduce risk factors in this population wherever possible, and utilize the latest technologies for prevention and early detection of colorectal cancer.

Screening
 
Colorectal screening allows doctors to find and remove polyps (small areas of tissue that can become cancerous), as well as discover colorectal tumors at an early stage, rather than waiting for symptoms to occur.

General guidelines for colorectal screening are as follows:
 
  • Colonoscopy every 10 years, beginning at age 50
 
  • Annual fecal occult blood test (described below), preferably combined with sigmoidoscopy every five years.

City of Hope recommends patients talk with their physician about when to begin screening for colorectal cancer. A colonoscopy may be advisable more frequently for individuals with polyps, inflammatory bowel disease, previous colorectal cancer and family members with colon cancer.

Diagnosing
 
Several different types of tests are used to examine the colon, rectum and stool for evidence of colon cancer, including:

  • Physical exam and history
 
  • Fecal occult blood test
    Small samples of stool are placed on chemically treated cards and examined for the microscopic presence of blood.
 
  • Digital rectal exam
    A doctor inserts a lubricated, gloved finger into the rectum to feel for lumps or abnormal areas.
 
  • Barium enema (also known as a lower GI series)
    For this examination, a liquid containing barium is placed into the rectum, which makes the colon and rectum easier to see in an X-ray.
 
  • Sigmoidoscopy
    In this test, a sigmoidoscope (a thin, lighted tube) is inserted through the rectum into the sigmoid colon. During the procedure, polyps or tissue samples may be removed for biopsy.
 
  • Colonoscopy
    A colonoscopy allows doctors to examine the entire colon and rectum for polyps, abnormal areas or cancer. In this test, a colonoscope (a thin, lighted tube) is inserted through the rectum into the colon and polyps or tissue samples may be taken for biopsy. Some colon polyps can be removed entirely during this procedure, which is performed under sedation.
 
  • Biopsy
    Tissue samples are examined under the microscope to determine what types of cells are present.
 
  • Virtual colonoscopy
    Also called colonography or CT colonography, this procedure uses a series of X-rays to create detailed pictures of the colon. The images are combined by computer in a process called computed tomography, or CT, to create detailed two- and three-dimensional images that can reveal polyps and other abnormalities inside the colon.
 
 

Colorectal Cancer Treatment Approaches

Our Treatment Approach to Colorectal Cancer

City of Hope brings together the most advanced resources to manage the treatment of patients with early and advanced colorectal cancers. Our team includes gastroenterologists, medical oncologists, radiation oncologists and surgical oncologists working cooperatively to create the most effective treatment plan.

In addition to conventional therapies, our clinical research programs offer patients access to promising new treatments.

Surgery
Surgery to remove cancerous tissue is a primary treatment at all stages of colorectal cancer. City of Hope surgeons are among the most experienced in the U.S. at treating colon cancer, and have excellent success rates using a range of advanced technologies.

Minimally Invasive and Laparoscopic Surgery
Surgery is the primary treatment used for localized tumors. When applicable, our specialists utilize minimally invasive surgery with advanced technologies such as laparoscopy and the new da Vinci S Surgical System with robotic capabilities that allows for greater precision. These surgeries feature small incisions and potentially:
 
  • Less blood loss, pain and visible incisions
  • Shorter hospital stays and recovery time
  • Fewer complications and quicker return to normal activities

One of the following surgical procedures may be used:
 
  • Local excision
    This surgery (sometimes called a polypectomy) is used to remove precancerous polyps and very small colon cancers.
  • Resection
    If a cancer is larger, a partial colectomy (removing the cancer and a margin of healthy tissue around it) may be performed. Lymph nodes near the colon may also be taken out and examined for signs of cancer. Usually, the surgeon will reattach the healthy parts of the colon back together.
  • Resection and colostomy
    In rare cases, the remaining parts of the colon cannot be reattached. Instead, an opening (stoma) is created on the outside of the body for waste to pass through. This procedure, called a colostomy, may be required only for a few months until the lower colon has healed, after which it can be reversed. However, if the entire lower colon needs to be removed, the colostomy may be permanent.
  • Radiofrequency ablation
    This procedure uses a special probe that kills cancer cells with electrical current. The probe may be inserted directly through the skin, or through an incision in the abdomen. Radiofrequency ablation is sometimes used to treat liver metastases from colon and rectal cancers.

Radiation and chemotherapy
Even if the surgeon can remove all signs of cancer that can be seen during an operation, patients may be given additional treatments. These may include chemotherapy or radiation therapy following surgery to kill any residual cancer cells.

Treatment given after surgery is called adjuvant therapy. In some patients with rectal cancer, chemotherapy and radiation therapy may be given before their operation to reduce the size of the tumor. This is called neoadjuvant therapy.

Radiation Therapy
Radiation therapy uses high-energy X-rays or other types of radiation to kill cancer cells. Our Department of Radiation Oncology was the first in the western United States to offer the Helical TomoTherapy Hi-Art System , one of the first radiation therapy systems of its kind to incorporate not only radiation therapy, but also tumor imaging capabilities comparable to a diagnostic computed tomography (CT) scan.

The helical TomoTherapy Hi-Art system integrates two types of technology – spiral CT scanning and intensity modulated radiation therapy, or IMRT – thus producing hundreds of pencil beams of radiation (each varying in intensity) that rotate spirally around a tumor. The high-dose region of radiation can be shaped or sculpted to fit the exact shape of each patient’s tumor, resulting in more effective and potentially curative doses to the cancer. This also reduces damage to normal tissues and results in fewer complications.

Chemotherapy
Chemotherapy drugs destroy cancer cells by interfering with their growth and multiplication. There are several methods by which these cancer-fighting medicines are delivered. In particular, City of Hope has been a pioneer in furthering the use of infusion chemotherapy to treat liver metastases arising from colorectal cancer.

Patients with liver metastases are evaluated for either resection or radiofrequency ablation. During surgery, a continuous infusion pump is placed under the skin to deliver anticancer medicine directly to the liver, in addition to chemotherapy given through a vein. This approach, called regional chemotherapy, has made major advances in controlling the spread of colorectal cancer.

Chemoradiation
Chemoradiation combines chemotherapy with radiation therapy to increase the effects of both. This strategy is often used for rectal cancers.

Heated Intraperitoneal Chemotherapy (HIPEC)
In the HIPEC procedure, the surgeon uses a special machine to pump high doses of heated chemotherapy drugs into the peritoneal cavity (the inner lining of the abdomen) while still in the operating room. The machine circulates the solution through the patient for up to two hours to reliably attack and eliminate any residual cancer cells that may remain after surgery. By bathing the abdomen with heated chemotherapy immediately following surgery, a higher dose of medication can be used than would normally be tolerated by a patient if given intravenously -- the traditional way chemotherapy is administered.

This type of chemotherapy is best at destroying cancer cells that are too small to be seen with the naked eye and prevents these cells from being left behind to form new cancerous tumors in the abdomen. The procedure also improves drug absorption and effect with minimal exposure to the rest of the body. In this way, the normal side effects of chemotherapy can be avoided.

Colorectal Cancer Resources

Colorectal Cancer Resources

All of our colorectal cancer patients have access to the Sheri & Les Biller Patient and Family Resource Center, which offers a wide array of support and educational services. Patients and loved ones may work with a coordinated group of social workers, psychiatrists, psychologists, patient navigators, pain management specialists and spiritual care providers at the center, as well as participate in programs such as music therapy, meditation and many others.
 
Additional Resources
C3-Colorectal Cancer Coalition
703-548-1225
C3 pushes for research to improve screening, diagnosis and treatment of colorectal cancer and encourages legislation for policy decisions.
 
Colon Cancer Alliance
877-422-2030
The Colon Cancer Alliance is a national patient advocacy organization that provides patient support, education and research information across North America.
 
American Cancer Society
800-ACS-2345
866-228-4327 for TYY
The American Cancer Society has many national and local programs, as well as a 24-hour support line, to help cancer survivors with problems such as travel, lodging and emotional issues.
 
National Comprehensive Cancer Network (NCCN)
888-909-NCCN (6226)
The National Comprehensive Cancer Network, an alliance of 19 of the world's leading cancer centers, is an authoritative source of information to help patients and health professionals make informed decisions about cancer care.
 
National Cancer Institute (NCI)
800-4-CANCER
The National Cancer Institute, established under the National Cancer Act of 1937, is the federal government's principal agency for cancer research and training.
 
U.S. Dept. of Health & Human Services National Institutes of Health (NIH)
301-496-4000
301-402-9612 for TYY
The National Institutes of Health (NIH) is one of the world's foremost medical research centers, and the federal focal point for medical research in the United States. The NIH, comprising 27 separate institutes and centers, is one of eight health agencies of the Public Health Service, which, in turn, is part of the U.S. Department of Health & Human Services.
 

Colorectal Cancer Research/Clinical Trials

City of Hope Colorectal Cancer Research and Clinical Trials

City of Hope has long been a leader in cancer research, including colorectal cancers. We are currently conducting multiple clinical trials of new chemotherapy drugs and other agents that may improve outcomes for patients with regionally metastatic and advanced disease, and prevent recurrence after treatment of early colorectal cancer.
 
Through our research program, patients gain access to promising new anticancer drugs and technologies that are not available to the general public. As a patient at City of Hope, you may qualify to participate in a test of these new investigational therapies.
 
Learn more about our clinical trials program and specifically about trials for colorectal cancer.
 
 

Colorectal Cancer Team

Colorectal Cancer Team

Support This Program

Support this program

It takes the help of a lot of caring people to make hope a reality for our patients. City of Hope was founded by individuals' philanthropic efforts 100 years ago. Their efforts − and those of our supporters today − have built the foundation for the care we provide and the research we conduct. It enables us to strive for new breakthroughs and better therapies − helping more people enjoy longer, better lives.

For more information on supporting this specific program, please contact us below.

Joe Komsky
Senior Director
Phone: 213-241-7293
Email: jkomsky@coh.org

 
 
Quick Links
ASCO 2014: Chemo with either Avastin or Erbitux are equallyeffective against colorectal cancer

ASCO 2014: Chemo with either Avastin or Erbitux are equally effective against colorectal cancer

Results from a large-scale study found that four commonly-prescribed drug regimens are equally effective for most types of colorectal cancer. The findings were presented during the plen...

June 2, 2014

 
Colonoscopy screenings: Hear the myths, get the facts(w/VIDEO)

Colonoscopy screenings: Hear the myths, get the facts (w/VIDEO)

Colonoscopy may not be the most pleasant of procedures, but it is one that can save your life. According to the National Cancer Institute, getting colonoscopies at recommended intervals (for most peop...

March 24, 2014

 
Colorectal cancer: Why more people are surviving thedisease

Colorectal cancer: Why more people are surviving the disease

For the past 20 years, the death rate for colorectal cancer has been dropping for both men and women. That decline can be traced to a number of factors, including advanced screening techniques, new dr...

March 18, 2014

 
Cancer of the breast, colon, lungs … Putting research inperspective

Cancer of the breast, colon, lungs … Putting research in perspective

No matter how impressive a research study’s conclusion may be – or how seemingly unsurprising – experts are needed to put the findings into context. Perhaps a study’s methodology wasn’t as strong...

March 3, 2014

 
Meet our doctors: Surgeon Stephen Sentovich on colorectalcancer

Meet our doctors: Surgeon Stephen Sentovich on colorectal cancer

Colon and rectal cancer is treatable and beatable – and early detection is of paramount importance. Yet despite research that shows colon and rectal cancer screening saves lives, recent data from the ...

January 14, 2014

 
Colon Cancer Treatment and Colonoscopies
 
Watch Dr. Stephen Sentovich talk about advances in colon cancer treatment and the importance of colonoscopies.
Clinical Trials
Our aggressive pursuit to discover better ways to help patients now – not years from now – places us among the leaders worldwide in the administration of clinical trials.
 
For 100 years, we’ve been a global leader in the fight against cancer, diabetes, and HIV/AIDS. Hope powers our dream of curing diseases that affect millions of people worldwide. We need help from people like you. Become a Citizen of Hope, and join us in the fight to save lives all over the world.
NEWS & UPDATES
  • Genetics, genes, genome, genetic risk … Such terms are becoming increasingly familiar to even nonresearchers as studies and information about the human make-up become more extensive and more critical. At City of Hope, these words have long been part of our vocabulary. Researchers and physicians are studyi...
  • Mammograms are currently the best method to detect breast cancer early, when it’s easier to treat and before it’s big enough to feel or cause symptoms. But recent mammogram screening guidelines may have left some women confused about when to undergo annual testing. Here Lusi Tumyan, M.D., chief of t...
  • Although chemotherapy can be effective in treating cancer, it can also exact a heavy toll on a patient’s health. One impressive alternative researchers have found is in the form of a vaccine. A type of immunotherapy, one part of the vaccine primes the body to react strongly against a tumor; the second part dire...
  • The breast cancer statistic is attention-getting: One in eight women will be diagnosed with breast cancer during her lifetime. That doesn’t mean that, if you’re one of eight women at a dinner table, one of you is fated to have breast cancer (read more on that breast cancer statistic), but it does mean that the ...
  • Rob Darakjian was diagnosed with acute lymphoblastic leukemia at just 19 years old. He began chemotherapy and was in and out of the hospital for four months. After his fourth round of treatment, he received a bone marrow transplantation from an anonymous donor. Today, he’s cancer free. In his first post, ...
  • Advanced age tops the list among breast cancer risk factor for women. Not far behind is family history and genetics. Two City of Hope researchers delving deep into these issues recently received important grants to advance their studies. Arti Hurria, M.D., director of the Cancer and Aging Research Program, and ...
  • City of Hope is extending the reach of its lifesaving mission well beyond U.S. borders. To that end, three distinguished City of Hope leaders visited China earlier this year to lay the foundation for the institution’s new International Medicine Program. The program is part of City of Hope’s strategi...
  • A hallmark of cancer is that it doesn’t always limit itself to a primary location. It spreads. Breast cancer and lung cancer in particular are prone to spread, or metastasize, to the brain. Often the brain metastasis isn’t discovered until years after the initial diagnosis, just when patients were beginning to ...
  • Blueberries, cinnamon, baikal scullcap, grape seed extract (and grape skin extract), mushrooms, barberry, pomegranates … all contain compounds with the potential to treat, or prevent, cancer. Scientists at City of Hope have found tantalizing evidence of this potential and are determined to explore it to t...
  • Most women who are treated for breast cancer with a mastectomy do not choose to undergo reconstructive surgery. The reasons for this, according to a recent JAMA Surgery study, vary. Nearly half say they do not want any additional surgery, while nearly 34 percent say breast cancer reconstruction simply isn’t imp...
  • The leading risk factor for breast cancer is simply being a woman. The second top risk factor is getting older. Obviously, these two factors cannot be controlled, which is why all women should be aware of their risk and how to minimize those risks. Many risk factors can be mitigated, and simple changes can lead...
  • All women are at some risk of developing the disease in their lifetimes, but breast cancer, like other cancers, has a disproportionate effect on minorities. Although white women have the highest incidence of breast cancer, African-American women have the highest breast cancer death rates of all racial and ethni...
  • First, the good news: HIV infections have dropped dramatically over the past 30 years. Doctors, researchers and health officials have made great strides in preventing and treating the disease, turning what was once a death sentence into, for some, a chronic condition. Now, the reality check: HIV is still a worl...
  • Screening for breast cancer has dramatically increased the number of cancers found before they cause symptoms – catching the disease when it is most treatable and curable. Mammograms, however, are not infallible. It’s important to conduct self-exams, and know the signs and symptoms that should be checked by a h...
  • Rob Darakjian was diagnosed with acute lymphoblastic leukemia at just 19 years old. He began chemotherapy and was in and out of the hospital for four months. After his fourth round of treatment, he received a bone marrow transplantation from an anonymous donor. Today, he’s cancer free.   In his previ...