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Cancer and Aging Research Program

The number of older patients with cancer and surviving cancer is rapidly growing because the U.S. population is aging with a projected doubling in the number of patients 65 and older by 2030. Although the majority of cancers occur in older adults, these patients have been under-represented in national cancer clinical trials, which set the standards for oncology care. Few studies have specifically focused on the unique issues which face older adults such as the impact of age related declines in physiology, polypharmacy or comorbid medical conditions on treatment tolerance.
 
Arti Hurria, M.D. leads City of Hope's Cancer and Aging Research Program, the mission of which is to join investigators from all cancer disciplines to study biology, treatment and survivorship issues that face older adults with cancer. The results of this research will be applicable to the majority of patients with cancer because approximately 60 percent of cancer diagnoses and 70 percent of cancer mortality occur in patients over the age of 65.
 
In addition, Hurria established the Cancer and Aging Research Group in order to further research in geriatric oncology. This group is comprised of physicians and researchers across the country who collaborate in many different clinical trials benefiting older adults.
 
Cancer and Aging Research Group (CARG) at mycarg.org: http://www.mycarg.org/
 

Research Focus

  • Research Focus
     
  • Role of Geriatric Assessment in the care of the older patient with cancer (understanding an individual’s physiologic age verses chronological age) 
     
  • Adjuvant treatment decisions in older patients with breast cancer
     
  • Cognitive effects of cancer therapy in older cancer patients
     
  • Pharmacokinetics of cancer therapy with aging
 

Cancer and Aging Research Program

Cancer and Aging Research Program

The number of older patients with cancer and surviving cancer is rapidly growing because the U.S. population is aging with a projected doubling in the number of patients 65 and older by 2030. Although the majority of cancers occur in older adults, these patients have been under-represented in national cancer clinical trials, which set the standards for oncology care. Few studies have specifically focused on the unique issues which face older adults such as the impact of age related declines in physiology, polypharmacy or comorbid medical conditions on treatment tolerance.
 
Arti Hurria, M.D. leads City of Hope's Cancer and Aging Research Program, the mission of which is to join investigators from all cancer disciplines to study biology, treatment and survivorship issues that face older adults with cancer. The results of this research will be applicable to the majority of patients with cancer because approximately 60 percent of cancer diagnoses and 70 percent of cancer mortality occur in patients over the age of 65.
 
In addition, Hurria established the Cancer and Aging Research Group in order to further research in geriatric oncology. This group is comprised of physicians and researchers across the country who collaborate in many different clinical trials benefiting older adults.
 
Cancer and Aging Research Group (CARG) at mycarg.org: http://www.mycarg.org/
 

Research Focus

Research Focus

  • Research Focus
     
  • Role of Geriatric Assessment in the care of the older patient with cancer (understanding an individual’s physiologic age verses chronological age) 
     
  • Adjuvant treatment decisions in older patients with breast cancer
     
  • Cognitive effects of cancer therapy in older cancer patients
     
  • Pharmacokinetics of cancer therapy with aging
 

Clinical Trials



NEWS & UPDATES
  • Equipping the immune system to fight cancer – a disease that thrives on mutations and circumventing the body’s natural defenses – is within reach. In fact, City of Hope researchers are testing one approach in clinical trials now. Scientists take a number of steps to turn cancer patients’ T cells – white b...
  • As treatments for lung cancer become more targeted and effective, the need for better technology to detect lung cancer mutations becomes increasingly important. A new clinical study at City of Hope is examining the feasibility of using blood and urine tests to detect lung cancer mutations, potentially allowing ...
  • When it comes to breast cancer risk, insulin levels may matter more than weight, new research has found. The study from Imperial College London School of Public Health, published in the journal Cancer Research, indicates that metabolic health – not a person’s weight or body mass index – increases breast cancer ...
  • No one ever plans to have cancer – and there’s never a good time. For Homa Sadat, her cancer came at a particularly bad time: just one year after losing her father to the pancreatic cancer he had battled for two years. She was working a grueling schedule managing three commercial office buildings. She’d just [&...
  • Patients at City of Hope – most of whom are fighting cancer – rely on more than 37,000 units of blood and platelets each year for their treatment and survival. Every one of those units comes from family, friends or someone who traded an hour or so of their time and a pint of their […]
  • Surgery is vital in the treatment of cancer – it’s used to help diagnose, treat and even prevent the disease – so a new colorectal cancer study linking a decrease in surgeries for advanced cancer to increased survival rates may raise more questions than it answers for some patients. The surgery-and-surviv...
  • Age is the single greatest risk factor overall for cancer; our chances of developing the disease rise steeply after age 50. For geriatric oncology nurse Peggy Burhenn, the meaning is clear: Cancer is primarily a geriatric condition. That’s why she is forging inroads in the care of older adults with cancer. Burh...
  • One of American’s great sportscasters, Stuart Scott, passed away from recurrent cancer of the appendix at the young age of 49. His cancer was diagnosed when he was only 40 years old. It was found during an operation for appendicitis. His courageous fight against this disease began in 2007, resumed again with an...
  • When Homa Sadat found a lump in her breast at age 27, her gynecologist told her what many doctors say to young women: You’re too young to have breast cancer. With the lump dismissed as a harmless cyst, she didn’t think about it again until she was at a restaurant six months later and felt […]
  • What most people call a “bone marrow transplant” is not actually a transplant of bone marrow; it is instead the transplantation of what’s known as hematopoietic stem cells. Such cells are often taken from bone marrow, but not always. Hematopoietic stem cells are simply immature cells that can ...
  • Doctors have long known that women with a precancerous condition called atypical hyperplasia have an elevated risk of breast cancer. Now a new study has found that the risk is more serious than previously thought. Hyperplasia itself is an overgrowth of cells; atypical hyperplasia is an overgrowth in a distorted...
  • Don’t kid yourself. Just because it’s mid-January doesn’t mean it’s too late to make resolutions for a happier, and healthier, 2015. Just consider them resolutions that are more mature than those giddy, sometimes self-deluded, Jan. 1 resolutions. To that end, we share some advice from Cary A. Presant, M.D., an ...
  • Sales and marketing executive Jim Murphy first came to City of Hope in 2002 to donate blood for a friend who was being treated for esophageal cancer. The disease is serious. Although esophageal cancer accounts for only about 1 percent of cancer diagnoses in the U.S., only about 20 percent of patients survive at...
  • Aaron Bomar and his family were celebrating his daughter’s 33rd birthday in September 2014 when he received alarming news: According to an X-ray taken earlier that day at an urgent care facility, he had a node on his aorta and was in danger of an aneurysm. Bomar held hands with his wife and daughter and s...
  • Explaining a prostate cancer diagnosis to a young child can be difficult — especially when the cancer is incurable. But conveying the need for prostate cancer research, as it turns out, is easily done. And that leads to action. Earlier this year, Gerald Rustad, 71, who is living with a very aggressive form of m...