City of Hope Bladder Cancer Research and Clinical Trials

Patients with an advanced stage of bladder cancer can find new hope at City of Hope, where we have long been a leader in bladder cancer research. Multiple clinical trials are ongoing, offering patients access to new and advanced treatments involving chemotherapy, radioimmunotherapy and radiation. City of Hope also maintains a large database of bladder cancer outcomes that aid in developing new treatment protocols.
Here are a few of the most promising trials underway:

Bladder Cancer Clinical Trials
Gene therapy
City of Hope investigators are collaborating on two studies that use an entirely novel approach to treating bladder cancer that has spread outside of the bladder. This approach entails the use of a drug that shuts down the genes that allow the cancer cell to respond under conditions of stress. 

Natural compounds (halichondrin)
In association with a group of California-based institutions, City of Hope is exploring the activity of a derivative from a sea sponge that can potentially have a profound effect on bladder cancer growth.

Investigators at City of Hope have received grants to examine the biologic features of bladder cancer.  Specifically, they are examining tissue outside of the bladder (such as lymph nodes) to determine if there are characteristics that can show a predisposition to the spreading of the cancer.  The grant will allow them to gather patient samples from more than 600 individuals across the country who were treated for bladder cancer.

Learn more about our clinical trials program and how you can participate in trials for bladder cancer.

Pioneering Research

Scientists at City of Hope are involved in pioneering research that will set the stage for the next generation of medical advances. These studies are in the emerging fields of molecular biology, molecular genetics, nanoscience and nanotechnology.

Molecular biology research has two goals.  One set of experiments is aimed at understanding how the RNA used by human cells to copy the ends of chromosomes is made and assembled in normal cells and cancer cells. The second set of experiments is aimed at understanding how patterns of methyl groups on DNA are lost and miscopied as we age and as cancer cells form.

The molecular genetics research is aimed at understanding how prostate cancer cells interfere with normal pathways in the synthesis of the building blocks of fat. Normally these pathways tell a cell that is about to become a cancer cell that it should stop growing and die in order to best preserve the whole body. Cancer cells, on the other hand, have special genes that block this process allowing them to continue to grow and ultimately form a cancerous growth.

The nanotechnology research seeks to exploit City of Hope’s patented bionanotechnology to use engineered DNA and protein to build tiny programmable machines (smaller than one thousandth the width of a human hair) that can find cancer cells and either mark them in a diagnostic procedure or perhaps selectively destroy them.