Endometrial/Uterine Cancer

City of Hope is at the forefront of some of the nation’s most promising endometrial and uterine cancer treatment and research programs. Our comprehensive and aggressive approach to endometrial and other types of uterine cancer involves screening to facilitate early detection, surgical treatments, including minimally-invasive robotic surgery, advanced therapies including intense-modulated-light radiotherapy and investigational chemotherapy drugs, as well as psychosocial, supportive and palliative care.

Our Gynecologic Oncology program delivers these services using the latest technology, providing the most effective, strategic and targeted care.
 
About Endometrial/Uterine Cancer
 
Uterine cancer is one of the more common cancers in women. It can technically be divided into endometrial cancer, or cancer of the uterine lining, and uterine sarcoma, which is a cancer arising from the myometrium, or muscle tissue of the uterus.
Endometrial cancer is defined as a disease in which cells of the endometrium become malignant, forming a tumor or tumors.
 
Endometrial/Uterine Cancer Risk Factors
 
Studies suggest the following may be risk factors for developing uterine cancer:
 
  • Age: Diagnosis often occurs after age 50; the average age at diagnosis is 60.
  • Race: White women are more likely to get uterine cancer.
  • Endometrial hyperplasia: A profusion of abnormal endometrial cells, manifesting as heavy menstrual bleeding or bleeding between periods or postmenopausal bleeding.
  • Early first menstruation: before age 12
  • Late menopause: after age 52
  • Exposure to high levels of estrogen: Oral contraceptives and hormone replacement therapy. Estrogen used without progesterone increases risk significantly compared to estrogen alone.
  • Never having been pregnant
  • Family history of the disease
  • Long-term tamoxifen therapy
  • Obesity and/or diabetes: These conditions promote increased estrogen levels.
  • History of colorectal cancer